FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2214304893> ?p ?o ?g. }

• W2214304893 endingPage "2755" @default.
• W2214304893 startingPage "2741" @default.
• W2214304893 abstract "Histone H3 lysine 4 trimethylation (H3K4me3) is known to correlate with both active and poised genomic loci, yet many questions remain regarding its functional roles in vivo. We identify functional genomic targets of two H3K4 methyltransferases, Set1 and MLL1/2, in both the stem cells and differentiated tissue of the planarian flatworm Schmidtea mediterranea. We show that, despite their common substrate, these enzymes target distinct genomic loci in vivo, which are distinguishable by the pattern each enzyme leaves on the chromatin template, i.e., the breadth of the H3K4me3 peak. Whereas Set1 targets are largely associated with the maintenance of the stem cell population, MLL1/2 targets are specifically enriched for genes involved in ciliogenesis. These data not only confirm that chromatin regulation is fundamental to planarian stem cell function but also provide evidence for post-embryonic functional specificity of H3K4me3 methyltransferases in vivo." @default.
• W2214304893 created "2016-06-24" @default.
• W2214304893 creator A5004397208 @default.
• W2214304893 creator A5027767510 @default.
• W2214304893 creator A5061204199 @default.
• W2214304893 creator A5083494274 @default.
• W2214304893 date "2015-12-01" @default.
• W2214304893 modified "2023-10-12" @default.
• W2214304893 title "Set1 and MLL1/2 Target Distinct Sets of Functionally Different Genomic Loci In Vivo" @default.
• W2214304893 cites W1968931043 @default.
• W2214304893 cites W1971015258 @default.
• W2214304893 cites W1971481058 @default.
• W2214304893 cites W1972752128 @default.
• W2214304893 cites W1974527796 @default.
• W2214304893 cites W1978062497 @default.
• W2214304893 cites W1993401016 @default.
• W2214304893 cites W2002797826 @default.
• W2214304893 cites W2015416439 @default.
• W2214304893 cites W2016024994 @default.
• W2214304893 cites W2024584416 @default.
• W2214304893 cites W2030523067 @default.
• W2214304893 cites W2031285837 @default.
• W2214304893 cites W2037589637 @default.
• W2214304893 cites W2041972715 @default.
• W2214304893 cites W2049284181 @default.
• W2214304893 cites W2058521801 @default.
• W2214304893 cites W2074324848 @default.
• W2214304893 cites W2074917365 @default.
• W2214304893 cites W2076441282 @default.
• W2214304893 cites W2078003979 @default.
• W2214304893 cites W2081015430 @default.
• W2214304893 cites W2084719919 @default.
• W2214304893 cites W2085184586 @default.
• W2214304893 cites W2089842581 @default.
• W2214304893 cites W2091856237 @default.
• W2214304893 cites W2091966685 @default.
• W2214304893 cites W2093822374 @default.
• W2214304893 cites W2095102047 @default.
• W2214304893 cites W2096611052 @default.
• W2214304893 cites W2108603029 @default.
• W2214304893 cites W2108709755 @default.
• W2214304893 cites W2111865215 @default.
• W2214304893 cites W2111984642 @default.
• W2214304893 cites W2115799739 @default.
• W2214304893 cites W2118542750 @default.
• W2214304893 cites W2120655432 @default.
• W2214304893 cites W2124406589 @default.
• W2214304893 cites W2126334907 @default.
• W2214304893 cites W2127921893 @default.
• W2214304893 cites W2137081894 @default.
• W2214304893 cites W2138743768 @default.
• W2214304893 cites W2142553004 @default.
• W2214304893 cites W2146463666 @default.
• W2214304893 cites W2147191899 @default.
• W2214304893 cites W2153476462 @default.
• W2214304893 cites W2161465043 @default.
• W2214304893 cites W2168887077 @default.
• W2214304893 cites W2887703191 @default.
• W2214304893 doi "https://doi.org/10.1016/j.celrep.2015.11.059" @default.
• W2214304893 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4707048" @default.
• W2214304893 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27732866" @default.
• W2214304893 hasPublicationYear "2015" @default.
• W2214304893 type Work @default.
• W2214304893 sameAs 2214304893 @default.
• W2214304893 citedByCount "54" @default.
• W2214304893 countsByYear W22143048932016 @default.
• W2214304893 countsByYear W22143048932017 @default.
• W2214304893 countsByYear W22143048932018 @default.
• W2214304893 countsByYear W22143048932019 @default.
• W2214304893 countsByYear W22143048932020 @default.
• W2214304893 countsByYear W22143048932021 @default.
• W2214304893 countsByYear W22143048932022 @default.
• W2214304893 countsByYear W22143048932023 @default.
• W2214304893 crossrefType "journal-article" @default.
• W2214304893 hasAuthorship W2214304893A5004397208 @default.
• W2214304893 hasAuthorship W2214304893A5027767510 @default.
• W2214304893 hasAuthorship W2214304893A5061204199 @default.
• W2214304893 hasAuthorship W2214304893A5083494274 @default.
• W2214304893 hasBestOaLocation W22143048931 @default.
• W2214304893 hasConcept C101762097 @default.
• W2214304893 hasConcept C104317684 @default.
• W2214304893 hasConcept C144024400 @default.
• W2214304893 hasConcept C149923435 @default.
• W2214304893 hasConcept C150194340 @default.
• W2214304893 hasConcept C150425827 @default.
• W2214304893 hasConcept C171056886 @default.
• W2214304893 hasConcept C190727270 @default.
• W2214304893 hasConcept C22709980 @default.
• W2214304893 hasConcept C2775935104 @default.
• W2214304893 hasConcept C2780914512 @default.
• W2214304893 hasConcept C28328180 @default.
• W2214304893 hasConcept C2908647359 @default.
• W2214304893 hasConcept C33288867 @default.
• W2214304893 hasConcept C41091548 @default.
• W2214304893 hasConcept C54355233 @default.
• W2214304893 hasConcept C83640560 @default.
• W2214304893 hasConcept C86803240 @default.
• W2214304893 hasConcept C91965660 @default.

• next