Matches in SemOpenAlex for { <https://semopenalex.org/work/W2214307223> ?p ?o ?g. }
- W2214307223 endingPage "94" @default.
- W2214307223 startingPage "82" @default.
- W2214307223 abstract "Renal dendritic cells are a major component of the renal mononuclear phagocytic system. In the renal interstitium, these cells are exposed to an osmotic gradient, mainly sodium, whose concentration progressively increases towards inner medulla. Renal allograft rejection affects predominantly the cortex, suggesting a protective role of the renal medullary micromilieu. Whether osmolar variations can modulate the function of renal dendritic cells is currently undefined. Considering the central role of dendritic cells in promoting allorejection, we tested whether the biophysical micromilieu, particularly the interstitial osmotic gradient, influences their alloreactivity. There was a progressive depletion of leukocytes towards the medulla of homeostatic kidney. Only macrophages opposed this tendency. Flow cytometry of homeostatic and post-transplant medullary dendritic cells revealed a switch towards a macrophage-like phenotype. Similarly, bone marrow-derived dendritic cells developed ex vivo in sodium chloride-enriched medium acquired a M2-like signature. Microarray analysis of allotransplant dendritic cells posed a medullary downregulation of genes mainly involved in alloantigen recognition. Gene expression profiles of both medullary dendritic cells and bone marrow-derived dendritic cells matured in hyperosmolar medium had an overlap with the macrophage M2 signature. Thus, the medullary environment inhibits an alloimmune response by modulating the phenotype and function of dendritic cells." @default.
- W2214307223 created "2016-06-24" @default.
- W2214307223 creator A5006430939 @default.
- W2214307223 creator A5006704169 @default.
- W2214307223 creator A5013946815 @default.
- W2214307223 creator A5014628848 @default.
- W2214307223 creator A5022496162 @default.
- W2214307223 creator A5044058691 @default.
- W2214307223 creator A5049156295 @default.
- W2214307223 creator A5068548177 @default.
- W2214307223 creator A5075113645 @default.
- W2214307223 creator A5087348033 @default.
- W2214307223 date "2016-01-01" @default.
- W2214307223 modified "2023-10-04" @default.
- W2214307223 title "The renal microenvironment modifies dendritic cell phenotype" @default.
- W2214307223 cites W1497894656 @default.
- W2214307223 cites W1518095394 @default.
- W2214307223 cites W1554580921 @default.
- W2214307223 cites W1561591381 @default.
- W2214307223 cites W1667820694 @default.
- W2214307223 cites W1882142355 @default.
- W2214307223 cites W1882571095 @default.
- W2214307223 cites W1935632736 @default.
- W2214307223 cites W1960367851 @default.
- W2214307223 cites W1965153168 @default.
- W2214307223 cites W1969207957 @default.
- W2214307223 cites W1969347248 @default.
- W2214307223 cites W1971800041 @default.
- W2214307223 cites W1982143675 @default.
- W2214307223 cites W1983765818 @default.
- W2214307223 cites W1991183726 @default.
- W2214307223 cites W2012136117 @default.
- W2214307223 cites W2016868307 @default.
- W2214307223 cites W2018325317 @default.
- W2214307223 cites W2020744745 @default.
- W2214307223 cites W2023890952 @default.
- W2214307223 cites W2025293338 @default.
- W2214307223 cites W2026578487 @default.
- W2214307223 cites W2032786670 @default.
- W2214307223 cites W2038793639 @default.
- W2214307223 cites W2051872988 @default.
- W2214307223 cites W2054581136 @default.
- W2214307223 cites W2055323879 @default.
- W2214307223 cites W2061123122 @default.
- W2214307223 cites W2068597132 @default.
- W2214307223 cites W2069891658 @default.
- W2214307223 cites W2070855360 @default.
- W2214307223 cites W2072924349 @default.
- W2214307223 cites W2079676318 @default.
- W2214307223 cites W2081098333 @default.
- W2214307223 cites W2084002680 @default.
- W2214307223 cites W2090909844 @default.
- W2214307223 cites W2093705034 @default.
- W2214307223 cites W2095659076 @default.
- W2214307223 cites W2097948046 @default.
- W2214307223 cites W2099263586 @default.
- W2214307223 cites W2104029407 @default.
- W2214307223 cites W2107277218 @default.
- W2214307223 cites W2111504178 @default.
- W2214307223 cites W2112087327 @default.
- W2214307223 cites W2112220625 @default.
- W2214307223 cites W2113947795 @default.
- W2214307223 cites W2114256642 @default.
- W2214307223 cites W2116414236 @default.
- W2214307223 cites W2118836795 @default.
- W2214307223 cites W2128921520 @default.
- W2214307223 cites W2130410032 @default.
- W2214307223 cites W2136188258 @default.
- W2214307223 cites W2136984446 @default.
- W2214307223 cites W2138879809 @default.
- W2214307223 cites W2140380746 @default.
- W2214307223 cites W2142084466 @default.
- W2214307223 cites W2144130278 @default.
- W2214307223 cites W2147714160 @default.
- W2214307223 cites W2148977472 @default.
- W2214307223 cites W2158054551 @default.
- W2214307223 cites W2158476280 @default.
- W2214307223 cites W2159442019 @default.
- W2214307223 cites W2166676682 @default.
- W2214307223 cites W2168203604 @default.
- W2214307223 cites W2168784022 @default.
- W2214307223 cites W4294216491 @default.
- W2214307223 doi "https://doi.org/10.1038/ki.2015.292" @default.
- W2214307223 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26466317" @default.
- W2214307223 hasPublicationYear "2016" @default.
- W2214307223 type Work @default.
- W2214307223 sameAs 2214307223 @default.
- W2214307223 citedByCount "39" @default.
- W2214307223 countsByYear W22143072232016 @default.
- W2214307223 countsByYear W22143072232017 @default.
- W2214307223 countsByYear W22143072232018 @default.
- W2214307223 countsByYear W22143072232019 @default.
- W2214307223 countsByYear W22143072232020 @default.
- W2214307223 countsByYear W22143072232021 @default.
- W2214307223 countsByYear W22143072232022 @default.
- W2214307223 countsByYear W22143072232023 @default.
- W2214307223 crossrefType "journal-article" @default.
- W2214307223 hasAuthorship W2214307223A5006430939 @default.