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• W2214405313 startingPage "3257" @default.
• W2214405313 abstract "ABSTRACT The recently identified arenavirus Lujo virus (LUJV) causes fatal hemorrhagic fever in humans. We analyzed its mechanism of viral release driven by matrix protein Z and the cell surface glycoprotein precursor GPC. The L domains in Z are required for efficient virus-like particle release, but Tsg101, ALIX/AIP1, and Vps4A/B are unnecessary for budding. LUJV GPC is cleaved by site 1 protease (S1P) at the RKLM motif, and treatment with the S1P inhibitor PF-429242 reduced LUJV production." @default.
• W2214405313 created "2016-06-24" @default.
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• W2214405313 date "2016-03-15" @default.
• W2214405313 modified "2023-10-04" @default.
• W2214405313 title "Analysis of Assembly and Budding of Lujo Virus" @default.
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• W2214405313 doi "https://doi.org/10.1128/jvi.03198-15" @default.
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