Matches in SemOpenAlex for { <https://semopenalex.org/work/W2214441821> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W2214441821 abstract "Sterol carrier protein-2 (SCP-2), which is not found in tissues of people with Zellweger syndrome, facilitates the movement of cholesterol within cells, resulting in abnormal accumulation of cholesterol in SCP-2-deficient cells. This study investigated whether synthetic high-density lipoprotein-like nanocarrier (sHDL-NC) improves the cellular transport of lysosomal cholesterol to plasma membrane in SCP-2-deficient fibroblasts. Human SCP-2-deficient fibroblasts were incubated with [(3)H-cholesterol]LDL as a source of cholesterol and sHDL-NC. The cells were fractionated by centrifugation permit tracking of [(3)H]-cholesterol from lysosome into plasma membrane. Furthermore, cellular content of cholesteryl ester as a storage form and mRNA expression of low-density lipoprotein (LDL) receptor were measured to support the cholesterol transport to plasma membrane. Incubation with sHDL-NC for 8 h significantly increased uptake of [(3)H]-cholesterol to lysosome by 53% and further enhanced the transport of [(3)H]-cholesterol to plasma membrane by 32%. Treatment with sHDL-NC significantly reduced cellular content of cholesteryl ester and increased mRNA expression of LDL receptor (LDL-R). In conclusion, sHDL-NC enables increased transport of lysosomal cholesterol to plasma membrane. In addition, these data were indirectly supported by decreased cellular content of cholesteryl ester and increased gene expression of LDL-R. Therefore, sHDL-NC may be a useful vehicle for transporting cholesterol, which may help to prevent accumulation of cholesterol in SCP-2-deficient fibroblasts." @default.
- W2214441821 created "2016-06-24" @default.
- W2214441821 creator A5007055913 @default.
- W2214441821 creator A5045134679 @default.
- W2214441821 creator A5064564379 @default.
- W2214441821 creator A5064660827 @default.
- W2214441821 date "2016-01-01" @default.
- W2214441821 modified "2023-09-26" @default.
- W2214441821 title "Synthetic High-Density Lipoprotein-Like Nanocarrier Improved Cellular Transport of Lysosomal Cholesterol in Human Sterol Carrier Protein-Deficient Fibroblasts" @default.
- W2214441821 doi "https://doi.org/10.1089/jmf.2015.3578" @default.
- W2214441821 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26684407" @default.
- W2214441821 hasPublicationYear "2016" @default.
- W2214441821 type Work @default.
- W2214441821 sameAs 2214441821 @default.
- W2214441821 citedByCount "1" @default.
- W2214441821 countsByYear W22144418212017 @default.
- W2214441821 crossrefType "journal-article" @default.
- W2214441821 hasAuthorship W2214441821A5007055913 @default.
- W2214441821 hasAuthorship W2214441821A5045134679 @default.
- W2214441821 hasAuthorship W2214441821A5064564379 @default.
- W2214441821 hasAuthorship W2214441821A5064660827 @default.
- W2214441821 hasConcept C110459506 @default.
- W2214441821 hasConcept C181199279 @default.
- W2214441821 hasConcept C185592680 @default.
- W2214441821 hasConcept C2776448209 @default.
- W2214441821 hasConcept C2778163477 @default.
- W2214441821 hasConcept C2778718757 @default.
- W2214441821 hasConcept C2779620165 @default.
- W2214441821 hasConcept C2780072125 @default.
- W2214441821 hasConcept C2780216420 @default.
- W2214441821 hasConcept C43554185 @default.
- W2214441821 hasConcept C55493867 @default.
- W2214441821 hasConcept C8004288 @default.
- W2214441821 hasConcept C8243546 @default.
- W2214441821 hasConceptScore W2214441821C110459506 @default.
- W2214441821 hasConceptScore W2214441821C181199279 @default.
- W2214441821 hasConceptScore W2214441821C185592680 @default.
- W2214441821 hasConceptScore W2214441821C2776448209 @default.
- W2214441821 hasConceptScore W2214441821C2778163477 @default.
- W2214441821 hasConceptScore W2214441821C2778718757 @default.
- W2214441821 hasConceptScore W2214441821C2779620165 @default.
- W2214441821 hasConceptScore W2214441821C2780072125 @default.
- W2214441821 hasConceptScore W2214441821C2780216420 @default.
- W2214441821 hasConceptScore W2214441821C43554185 @default.
- W2214441821 hasConceptScore W2214441821C55493867 @default.
- W2214441821 hasConceptScore W2214441821C8004288 @default.
- W2214441821 hasConceptScore W2214441821C8243546 @default.
- W2214441821 hasLocation W22144418211 @default.
- W2214441821 hasLocation W22144418212 @default.
- W2214441821 hasOpenAccess W2214441821 @default.
- W2214441821 hasPrimaryLocation W22144418211 @default.
- W2214441821 hasRelatedWork W1936109784 @default.
- W2214441821 hasRelatedWork W2018377654 @default.
- W2214441821 hasRelatedWork W2018746110 @default.
- W2214441821 hasRelatedWork W2098564893 @default.
- W2214441821 hasRelatedWork W2112233943 @default.
- W2214441821 hasRelatedWork W2136512187 @default.
- W2214441821 hasRelatedWork W2182957596 @default.
- W2214441821 hasRelatedWork W2187146142 @default.
- W2214441821 hasRelatedWork W2214441821 @default.
- W2214441821 hasRelatedWork W2184654009 @default.
- W2214441821 isParatext "false" @default.
- W2214441821 isRetracted "false" @default.
- W2214441821 magId "2214441821" @default.
- W2214441821 workType "article" @default.