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- W2214447417 abstract "Replacement therapy for patients with hemophilia A using plasma-derived or recombinant factor VIII (FVIII) is complicated by the short half-life of the FVIII products and by the occurrence of neutralizing antibodies in a substantial number of patients. In the recent years, enormous efforts have been invested to develop new generations of coagulation factors with extended half-lives. Presumably, the use of long-lasting FVIII products should reduce the frequency of administration to the patients and drastically improve their quality of life. The question of their immunogenicity remains however unanswered as yet. The present review proposes a summary of the different strategies developed to enhance the half-life of FVIII, including fusion of FVIII to the Fc fragment of the human IgG1 or to human serum albumin, or attachment of polyethylene glycol. Based on the available literature, we hypothesize on the potential benefits or risks associated with each of the latter strategies in terms of immunogenicity of the newly derived hemostatic drugs." @default.
- W2214447417 created "2016-06-24" @default.
- W2214447417 creator A5011054557 @default.
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- W2214447417 creator A5054422735 @default.
- W2214447417 creator A5065225207 @default.
- W2214447417 date "2016-03-01" @default.
- W2214447417 modified "2023-10-18" @default.
- W2214447417 title "Immunogenicity of long-lasting recombinant factor VIII products" @default.
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- W2214447417 doi "https://doi.org/10.1016/j.cellimm.2015.12.006" @default.
- W2214447417 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26723503" @default.
- W2214447417 hasPublicationYear "2016" @default.
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