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- W2214463082 abstract "Individuals who smoke tobacco overwhelmingly drink alco- hol and vice versa. We previously observed functional interaction and cross-tolerance between alcohol and intracerebellar (ICB) nicotine. We now report their mediation by cerebellar nNOS in male CD-1 mice. Nicotine and nNOS inhibitor (nNOSI); N-((4S)-4-amino-5- ((2-aminoethyl)amino)pentyl)-N � -nitroguanidine tris(trifluoroacetate) salt, were directly infused into the cerebellum while ethanol was injected IP. Ethanol (2 g/kg)-induced ataxia (EIA) was potentiated by nNOSI (0.1, 0.5, 1.0 ng) suggesting nNOS-mediation. Pretreatment with nNOSI (0.5, 1.0, 2.0 ng) dose-dependently antagonized nicotine (5 ng)-induced attenuation of EIA suggesting involvement of cerebellar nNOS. When nNOSI (0.5, 1.0, 2.0 ng) and nicotine (5 ng) were microinfused once daily for 5 days, followed 16 h later by ethanol, virtual absence of cross-tolerance was noted. However, when aCSF was infused instead of nNOSI, robust cross-tolerance was noted confirming mediation by cerebellar nNOS system. Overall, these results support role of the cerebellar nNOS in cross-tolerance between ethanol and nicotine." @default.
- W2214463082 created "2016-06-24" @default.
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- W2214463082 date "2013-01-01" @default.
- W2214463082 modified "2023-10-16" @default.
- W2214463082 title "Involvement of Mouse Cerebellar Neuronal Nitric Oxide Synthase (nNOS) System in the Functional Interaction and Cross-Tolerance between Nicotine and Ethanol" @default.
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- W2214463082 doi "https://doi.org/10.4303/jdar/235788" @default.
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