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- W2214496580 abstract "The most common paradoxical manifestations related to tumour necrosis factor (TNF) antagonists include psoriasiform skin lesions and the occurrence of arthralgia, which have been observed in patients with Crohn’s disease and ulcerative colitis treated with anti-TNFs.1 Nevertheless, these drugs are successfully used to treat patients with psoriasis and rheumatoid arthritis. Given that these symptoms can also occur as extra-intestinal manifestations of inflammatory bowel disease (IBD), their management is challenging.Drug exposure has been brought forward as a contributing factor but has never been studied in detail. In this issue of JCC, two studies from the Netherlands2 and France3 have sought to prospectively evaluate the association between TNF antagonist trough concentrations (i.e. the serum drug concentration just before the next administration of drug) and the occurrence of drug-induced paradoxical manifestations. Outcome measures included health- and disease-related quality of life … Corresponding author: Niels Vande Casteele, Herestraat 49, PO 820, 3000 Leuven, Belgium. Tel: 3216377205; Email: niels.vandecasteele{at}kuleuven.be" @default.
- W2214496580 created "2016-06-24" @default.
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- W2214496580 date "2015-09-07" @default.
- W2214496580 modified "2023-10-11" @default.
- W2214496580 title "High Anti-Tumour Necrosis Factor Trough Concentrations – Only a Cost Issue or Also Hidden Dangers Ahead?" @default.
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- W2214496580 doi "https://doi.org/10.1093/ecco-jcc/jjv146" @default.
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