Matches in SemOpenAlex for { <https://semopenalex.org/work/W2214587777> ?p ?o ?g. }
- W2214587777 endingPage "60" @default.
- W2214587777 startingPage "51" @default.
- W2214587777 abstract "There is an urgent need to develop nanocarriers for the treatment of glioblastoma multiforme (GBM). Using co-registered positron emission tomography (PET) and magnetic resonance (MR) images, here we performed systematic studies to investigate how a nanocarrier's size affects the pharmacokinetics and biodistribution in rodents with a GBM xenograft. In particular, highly stable, long-circulating three-helix micelles (3HM), based on a coiled-coil protein tertiary structure, were evaluated as an alternative to larger nanocarriers. While the circulation half-life of the 3HM was similar to 110-nm PEGylated liposomes (t1/2 = 15.5 and 16.5 h, respectively), the 20-nm micelles greatly enhanced accumulation within a U87MG xenograft in nu/nu rats after intravenous injection. After accounting for tumor blood volume, the extravasated nanoparticles were quantified from the PET images, yielding ~ 0.77%ID/cm3 for the micelles and 0.45%ID/cm3 for the liposomes. For GBM lesions with a volume greater than 100 mm3, 3HM accumulation was enhanced both within the detectable tumor and in the surrounding brain parenchyma. Further, the nanoparticle accumulation was shown to extend to the margins of the GBM xenograft. In summary, 3HM provides an attractive nanovehicle for carrying treatment to GBM." @default.
- W2214587777 created "2016-06-24" @default.
- W2214587777 creator A5008415707 @default.
- W2214587777 creator A5010360323 @default.
- W2214587777 creator A5013037422 @default.
- W2214587777 creator A5040555359 @default.
- W2214587777 creator A5040646072 @default.
- W2214587777 creator A5057079069 @default.
- W2214587777 creator A5060126145 @default.
- W2214587777 creator A5062541015 @default.
- W2214587777 creator A5074717790 @default.
- W2214587777 creator A5081795552 @default.
- W2214587777 creator A5082015021 @default.
- W2214587777 date "2015-12-01" @default.
- W2214587777 modified "2023-10-01" @default.
- W2214587777 title "Self-assembled 20-nm 64Cu-micelles enhance accumulation in rat glioblastoma" @default.
- W2214587777 cites W1257280450 @default.
- W2214587777 cites W1512493964 @default.
- W2214587777 cites W1535767909 @default.
- W2214587777 cites W179710673 @default.
- W2214587777 cites W1893588436 @default.
- W2214587777 cites W1978654303 @default.
- W2214587777 cites W1980696916 @default.
- W2214587777 cites W1982913214 @default.
- W2214587777 cites W1985858988 @default.
- W2214587777 cites W1988368325 @default.
- W2214587777 cites W1988771852 @default.
- W2214587777 cites W1992726856 @default.
- W2214587777 cites W2005173259 @default.
- W2214587777 cites W2005542583 @default.
- W2214587777 cites W2008920831 @default.
- W2214587777 cites W2014485768 @default.
- W2214587777 cites W2015541518 @default.
- W2214587777 cites W2022912277 @default.
- W2214587777 cites W2034949506 @default.
- W2214587777 cites W2036044314 @default.
- W2214587777 cites W2039495834 @default.
- W2214587777 cites W2039940721 @default.
- W2214587777 cites W2044903133 @default.
- W2214587777 cites W2051337762 @default.
- W2214587777 cites W2052757271 @default.
- W2214587777 cites W2056287310 @default.
- W2214587777 cites W2058521348 @default.
- W2214587777 cites W2060116019 @default.
- W2214587777 cites W2061264526 @default.
- W2214587777 cites W2065023628 @default.
- W2214587777 cites W2068203421 @default.
- W2214587777 cites W2079142824 @default.
- W2214587777 cites W2083710155 @default.
- W2214587777 cites W2090866080 @default.
- W2214587777 cites W2096287682 @default.
- W2214587777 cites W2097857976 @default.
- W2214587777 cites W2097980094 @default.
- W2214587777 cites W2098708609 @default.
- W2214587777 cites W2110475445 @default.
- W2214587777 cites W2112882669 @default.
- W2214587777 cites W2118641614 @default.
- W2214587777 cites W2124736921 @default.
- W2214587777 cites W2127155176 @default.
- W2214587777 cites W2132697290 @default.
- W2214587777 cites W2139616692 @default.
- W2214587777 cites W2140181820 @default.
- W2214587777 cites W2141851994 @default.
- W2214587777 cites W2150146274 @default.
- W2214587777 cites W2152038397 @default.
- W2214587777 cites W2153200726 @default.
- W2214587777 cites W2156330848 @default.
- W2214587777 cites W2158681922 @default.
- W2214587777 cites W2160382843 @default.
- W2214587777 cites W2164049072 @default.
- W2214587777 cites W2165871546 @default.
- W2214587777 cites W2169369050 @default.
- W2214587777 cites W2202001486 @default.
- W2214587777 cites W2323737385 @default.
- W2214587777 cites W3020922425 @default.
- W2214587777 cites W3036895338 @default.
- W2214587777 cites W845003 @default.
- W2214587777 doi "https://doi.org/10.1016/j.jconrel.2015.09.057" @default.
- W2214587777 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4688122" @default.
- W2214587777 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26437259" @default.
- W2214587777 hasPublicationYear "2015" @default.
- W2214587777 type Work @default.
- W2214587777 sameAs 2214587777 @default.
- W2214587777 citedByCount "52" @default.
- W2214587777 countsByYear W22145877772016 @default.
- W2214587777 countsByYear W22145877772017 @default.
- W2214587777 countsByYear W22145877772018 @default.
- W2214587777 countsByYear W22145877772019 @default.
- W2214587777 countsByYear W22145877772020 @default.
- W2214587777 countsByYear W22145877772021 @default.
- W2214587777 countsByYear W22145877772022 @default.
- W2214587777 countsByYear W22145877772023 @default.
- W2214587777 crossrefType "journal-article" @default.
- W2214587777 hasAuthorship W2214587777A5008415707 @default.
- W2214587777 hasAuthorship W2214587777A5010360323 @default.
- W2214587777 hasAuthorship W2214587777A5013037422 @default.
- W2214587777 hasAuthorship W2214587777A5040555359 @default.
- W2214587777 hasAuthorship W2214587777A5040646072 @default.