FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2214593087> ?p ?o ?g. }

• W2214593087 endingPage "1832" @default.
• W2214593087 startingPage "1827" @default.
• W2214593087 abstract "Andrographolide is an active component from the extract of Andrographis paniculata [(Burm.f) Nees], a medicinal plant from the Acanthaceae family. Pharmacological studies have revealed that andrographolide possesses anti-bacterial, anti-inflammatory, anti-viral, immune regulatory and hepatoprotective properties, and is efficacious in the treatment of cardiovascular diseases, while exhibiting low toxicity and low cost. The present study aimed to determine the inhibitory effects of andrographolide on the growth of multiple myeloma (MM) cells and its possible impact on the Toll-like receptor (TLR)4/nuclear factor (NF)-κB signaling pathway. Cell proliferation was detected using an MTT assay, cellular apoptosis was measured using flow cytometry, and caspase-9/3 activation were assessed using colorimetric assay kits. Furthermore, TLR4 and NF-κB protein expression was determined by western blot analysis. The results revealed that andrographolide reduced the proliferation, while increasing cellular apoptosis and caspase-9/3 activation of MM cells, in addition to downregulating the expression of TLR4 and NF-κB protein. Of note, TLR4- or NF-κB-targeting small-interfering (si)RNA enhanced the andrographolide-induced inhibition of cell proliferation and induction of apoptosis of MM cells. The results of the present study therefore suggested that andrographolide inhibited multiple myeloma cells via the TLR4/NF-κB signaling pathway." @default.
• W2214593087 created "2016-06-24" @default.
• W2214593087 creator A5074322926 @default.
• W2214593087 creator A5088366112 @default.
• W2214593087 date "2015-12-22" @default.
• W2214593087 modified "2023-10-14" @default.
• W2214593087 title "Andrographolide inhibits multiple myeloma cells by inhibiting the TLR4/NF-κB signaling pathway" @default.
• W2214593087 cites W1743171475 @default.
• W2214593087 cites W1862941132 @default.
• W2214593087 cites W1894198394 @default.
• W2214593087 cites W1894829161 @default.
• W2214593087 cites W1972995249 @default.
• W2214593087 cites W1974335344 @default.
• W2214593087 cites W1983881321 @default.
• W2214593087 cites W1989555154 @default.
• W2214593087 cites W1993079638 @default.
• W2214593087 cites W2007105598 @default.
• W2214593087 cites W2045792033 @default.
• W2214593087 cites W2045985825 @default.
• W2214593087 cites W2047084807 @default.
• W2214593087 cites W2048444534 @default.
• W2214593087 cites W2054871083 @default.
• W2214593087 cites W2061230659 @default.
• W2214593087 cites W2062946715 @default.
• W2214593087 cites W2064702122 @default.
• W2214593087 cites W2065081315 @default.
• W2214593087 cites W2071432007 @default.
• W2214593087 cites W2076732341 @default.
• W2214593087 cites W2079395387 @default.
• W2214593087 cites W2104276418 @default.
• W2214593087 cites W2122226574 @default.
• W2214593087 cites W2133839915 @default.
• W2214593087 cites W2156958220 @default.
• W2214593087 cites W2167805434 @default.
• W2214593087 doi "https://doi.org/10.3892/mmr.2015.4703" @default.
• W2214593087 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26707811" @default.
• W2214593087 hasPublicationYear "2015" @default.
• W2214593087 type Work @default.
• W2214593087 sameAs 2214593087 @default.
• W2214593087 citedByCount "38" @default.
• W2214593087 countsByYear W22145930872016 @default.
• W2214593087 countsByYear W22145930872017 @default.
• W2214593087 countsByYear W22145930872018 @default.
• W2214593087 countsByYear W22145930872019 @default.
• W2214593087 countsByYear W22145930872020 @default.
• W2214593087 countsByYear W22145930872021 @default.
• W2214593087 countsByYear W22145930872022 @default.
• W2214593087 countsByYear W22145930872023 @default.
• W2214593087 crossrefType "journal-article" @default.
• W2214593087 hasAuthorship W2214593087A5074322926 @default.
• W2214593087 hasAuthorship W2214593087A5088366112 @default.
• W2214593087 hasBestOaLocation W22145930871 @default.
• W2214593087 hasConcept C104317684 @default.
• W2214593087 hasConcept C123298856 @default.
• W2214593087 hasConcept C142724271 @default.
• W2214593087 hasConcept C185592680 @default.
• W2214593087 hasConcept C190283241 @default.
• W2214593087 hasConcept C204787440 @default.
• W2214593087 hasConcept C2776070231 @default.
• W2214593087 hasConcept C2777730290 @default.
• W2214593087 hasConcept C2777970627 @default.
• W2214593087 hasConcept C2780783641 @default.
• W2214593087 hasConcept C2781357234 @default.
• W2214593087 hasConcept C29537977 @default.
• W2214593087 hasConcept C502942594 @default.
• W2214593087 hasConcept C55493867 @default.
• W2214593087 hasConcept C62112901 @default.
• W2214593087 hasConcept C62478195 @default.
• W2214593087 hasConcept C71924100 @default.
• W2214593087 hasConcept C86339819 @default.
• W2214593087 hasConcept C86803240 @default.
• W2214593087 hasConcept C95444343 @default.
• W2214593087 hasConcept C98274493 @default.
• W2214593087 hasConceptScore W2214593087C104317684 @default.
• W2214593087 hasConceptScore W2214593087C123298856 @default.
• W2214593087 hasConceptScore W2214593087C142724271 @default.
• W2214593087 hasConceptScore W2214593087C185592680 @default.
• W2214593087 hasConceptScore W2214593087C190283241 @default.
• W2214593087 hasConceptScore W2214593087C204787440 @default.
• W2214593087 hasConceptScore W2214593087C2776070231 @default.
• W2214593087 hasConceptScore W2214593087C2777730290 @default.
• W2214593087 hasConceptScore W2214593087C2777970627 @default.
• W2214593087 hasConceptScore W2214593087C2780783641 @default.
• W2214593087 hasConceptScore W2214593087C2781357234 @default.
• W2214593087 hasConceptScore W2214593087C29537977 @default.
• W2214593087 hasConceptScore W2214593087C502942594 @default.
• W2214593087 hasConceptScore W2214593087C55493867 @default.
• W2214593087 hasConceptScore W2214593087C62112901 @default.
• W2214593087 hasConceptScore W2214593087C62478195 @default.
• W2214593087 hasConceptScore W2214593087C71924100 @default.
• W2214593087 hasConceptScore W2214593087C86339819 @default.
• W2214593087 hasConceptScore W2214593087C86803240 @default.
• W2214593087 hasConceptScore W2214593087C95444343 @default.
• W2214593087 hasConceptScore W2214593087C98274493 @default.
• W2214593087 hasIssue "2" @default.
• W2214593087 hasLocation W22145930871 @default.
• W2214593087 hasLocation W22145930872 @default.
• W2214593087 hasOpenAccess W2214593087 @default.

• next