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- W2214600892 abstract "Bacterial toxins are widespread in the environment as well as in the digestive system of humans and animals. Toxin from Gram-negative bacteria (endotoxin or lipopolysaccharide; LPS) has a life-long programming effect on reproduction in rats, but the mediators have not been well-documented, so we investigated the effects of LPS on the timing of puberty in female rats. Because the levels of nitric oxide (NO) and interleukin 1β (IL-1β) increase following injection of LPS, we injected neonates (post-natal day (pnd) 7) with LPS, with or without NO or IL-1β inhibitors. Half of the prepubescent (pnd 30) animals received an additional LPS injection. Vaginal opening, number of ovarian follicles, and serum anti-LPS antibodies were determined. A single LPS injection was sufficient to reduce the primordial follicle pool, but puberty was delayed when rats received 2 LPS injections (at pnd 7 and 30). NO or IL-1β inhibitors improved both of these parameters, suggesting that the early detrimental effects of LPS on puberty and primordial follicle pool are mediated by NO and IL-1β." @default.
- W2214600892 created "2016-06-24" @default.
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- W2214600892 date "2015-08-01" @default.
- W2214600892 modified "2023-09-24" @default.
- W2214600892 title "Endotoxin exposure and puberty in female rats: the role of nitric oxide and caspase-1 inhibition in neonates" @default.
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- W2214600892 doi "https://doi.org/10.1139/cjpp-2014-0559" @default.
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