FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2214689989> ?p ?o ?g. }

• W2214689989 endingPage "93" @default.
• W2214689989 startingPage "84" @default.
• W2214689989 abstract "Previously we found that late pregnancy total and free thyroxine (TT4, FT4) concentrations were negatively related to greater pre and/or postpartum depressive symptoms. In a much larger cohort, the current study examined whether these thyroid indices measured earlier in the third trimester (31–33 weeks) predict subsequent perinatal depression and anxiety ratings as well as syndromal depression. Thyroid-binding globulin (TBG) concentrations increase markedly during pregnancy and may be an index of sensitivity to elevated estrogen levels. TBG was examined in this study because prior findings suggest that postpartum depression is related to sensitivity to mood destabilization by elevated sex hormone concentrations during pregnancy. Our cohort was 199 euthyroid women recruited from a public health obstetrics clinic (63.8% Hispanic, 21.6% Black). After screening and blood draws for hormone measures at pregnancy weeks 31–33, subjects were evaluated during home visits at pregnancy weeks 35–36 as well as postpartum weeks 6 and 12. Evaluations included psychiatric interviews for current and life-time DSM-IV psychiatric history (M.I.N.I.-Plus), subject self-ratings and interviewer ratings for depression and anxiety (Edinburgh Postnatal Depression Scale, Montgomery-Ǻsberg Depression Rating Scale; Spielberger State-Trait Anxiety Inventory, Hamilton Anxiety Inventory), as well as a standardized interview to obtain life-time trauma history. Numerous covariates were included in all regression analyses. Trauma and major depression history were robustly significant predictors of depression and anxiety ratings over the study period when these variables were analyzed individually or in a combined model including FT4 or TBG (p < .001). When analyzed alone, FT4 levels were a less strong but still significant predictor of all depression and anxiety ratings (p < .05) while TBG levels was a significant or nearly significant predictor of most ratings. FT4, TBG and trauma history, but not major depression history, were significant individual predictors of syndromal depression during the study period (p < .05) in single predictor models. In models combining each with trauma and major depression history, FT4 and TBG generally were not significantly predictive of depression or anxiety ratings, and FT4 was also not a significant predictor of syndromal depression: however, in the combined model TBG was a particularly strong predictor of perinatal syndromal depression (p = .005) and trauma history was also significant (p = .016). Further study of the interactions among TBG, FT4, sex hormones, trauma history and perinatal depression may provide insights into the pathophysiological basis of individual variance in vulnerability to mood destabilization by the hormone conditions of pregnancy." @default.
• W2214689989 created "2016-06-24" @default.
• W2214689989 creator A5000446863 @default.
• W2214689989 creator A5000689935 @default.
• W2214689989 creator A5004250205 @default.
• W2214689989 creator A5072502852 @default.
• W2214689989 creator A5079105055 @default.
• W2214689989 creator A5079594160 @default.
• W2214689989 date "2016-03-01" @default.
• W2214689989 modified "2023-10-16" @default.
• W2214689989 title "Late pregnancy thyroid-binding globulin predicts perinatal depression" @default.
• W2214689989 cites W1835924110 @default.
• W2214689989 cites W1963991796 @default.
• W2214689989 cites W1971631504 @default.
• W2214689989 cites W1977940113 @default.
• W2214689989 cites W1978814746 @default.
• W2214689989 cites W1984784098 @default.
• W2214689989 cites W1985535608 @default.
• W2214689989 cites W1986811803 @default.
• W2214689989 cites W1987184305 @default.
• W2214689989 cites W1990584061 @default.
• W2214689989 cites W1990875303 @default.
• W2214689989 cites W1992657280 @default.
• W2214689989 cites W1992942888 @default.
• W2214689989 cites W2012109041 @default.
• W2214689989 cites W2015790142 @default.
• W2214689989 cites W2016677827 @default.
• W2214689989 cites W2017053191 @default.
• W2214689989 cites W2018513134 @default.
• W2214689989 cites W2023203793 @default.
• W2214689989 cites W2024558594 @default.
• W2214689989 cites W2029525545 @default.
• W2214689989 cites W2031769962 @default.
• W2214689989 cites W2031909422 @default.
• W2214689989 cites W2032987539 @default.
• W2214689989 cites W2042586591 @default.
• W2214689989 cites W2046694858 @default.
• W2214689989 cites W2049165791 @default.
• W2214689989 cites W2049730824 @default.
• W2214689989 cites W2055367243 @default.
• W2214689989 cites W2063633162 @default.
• W2214689989 cites W2063659102 @default.
• W2214689989 cites W2071802871 @default.
• W2214689989 cites W2074030562 @default.
• W2214689989 cites W2074280303 @default.
• W2214689989 cites W2080326569 @default.
• W2214689989 cites W2082359311 @default.
• W2214689989 cites W2095137916 @default.
• W2214689989 cites W2101356015 @default.
• W2214689989 cites W2106279703 @default.
• W2214689989 cites W2111438126 @default.
• W2214689989 cites W2112418246 @default.
• W2214689989 cites W2113790811 @default.
• W2214689989 cites W2115742753 @default.
• W2214689989 cites W2124170577 @default.
• W2214689989 cites W2131823335 @default.
• W2214689989 cites W2131944002 @default.
• W2214689989 cites W2146985664 @default.
• W2214689989 cites W2149264570 @default.
• W2214689989 cites W2157225627 @default.
• W2214689989 cites W2160070901 @default.
• W2214689989 cites W2161941379 @default.
• W2214689989 cites W2171493587 @default.
• W2214689989 cites W2171912784 @default.
• W2214689989 cites W2172024505 @default.
• W2214689989 cites W2397453310 @default.
• W2214689989 cites W300925921 @default.
• W2214689989 cites W3171418018 @default.
• W2214689989 doi "https://doi.org/10.1016/j.psyneuen.2015.12.010" @default.
• W2214689989 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4752891" @default.
• W2214689989 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26731573" @default.
• W2214689989 hasPublicationYear "2016" @default.
• W2214689989 type Work @default.
• W2214689989 sameAs 2214689989 @default.
• W2214689989 citedByCount "26" @default.
• W2214689989 countsByYear W22146899892016 @default.
• W2214689989 countsByYear W22146899892017 @default.
• W2214689989 countsByYear W22146899892018 @default.
• W2214689989 countsByYear W22146899892019 @default.
• W2214689989 countsByYear W22146899892020 @default.
• W2214689989 countsByYear W22146899892021 @default.
• W2214689989 countsByYear W22146899892022 @default.
• W2214689989 countsByYear W22146899892023 @default.
• W2214689989 crossrefType "journal-article" @default.
• W2214689989 hasAuthorship W2214689989A5000446863 @default.
• W2214689989 hasAuthorship W2214689989A5000689935 @default.
• W2214689989 hasAuthorship W2214689989A5004250205 @default.
• W2214689989 hasAuthorship W2214689989A5072502852 @default.
• W2214689989 hasAuthorship W2214689989A5079105055 @default.
• W2214689989 hasAuthorship W2214689989A5079594160 @default.
• W2214689989 hasBestOaLocation W22146899892 @default.
• W2214689989 hasConcept C118552586 @default.
• W2214689989 hasConcept C126322002 @default.
• W2214689989 hasConcept C131872663 @default.
• W2214689989 hasConcept C139719470 @default.
• W2214689989 hasConcept C15744967 @default.
• W2214689989 hasConcept C162324750 @default.
• W2214689989 hasConcept C2776867660 @default.

• next