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- W2214717963 abstract "Purpose of review This article describes the mechanisms and consequences of both microbial translocation and microbial dysbiosis in HIV infection. Recent findings Microbes in HIV are likely playing a large role in contributing to HIV pathogenesis, morbidities and mortality. Two major disruptions to microbial systems in HIV infection include microbial translocation and microbiome dysbiosis. Microbial translocation occurs when the bacteria (or bacterial products) that should be in the lumen of the intestine translocate across the tight epithelial barrier into systemic circulation, where they contribute to inflammation and pathogenesis. This is associated with poorer health outcomes in HIV-infected individuals. In addition, microbial populations in the gastrointestinal tract are also altered after HIV infection, resulting in microbiome dysbiosis, which further exacerbates microbial translocation, epithelial barrier disruption, inflammation and mucosal immune functioning. Summary Altered microbial regulation in HIV infection can lead to poor health outcomes, and understanding the mechanisms underlying microbial dysbiosis and translocation may result in novel pathways for therapeutic interventions." @default.
- W2214717963 created "2016-06-24" @default.
- W2214717963 creator A5019501394 @default.
- W2214717963 creator A5032528802 @default.
- W2214717963 creator A5073843981 @default.
- W2214717963 creator A5087636291 @default.
- W2214717963 date "2016-03-01" @default.
- W2214717963 modified "2023-10-18" @default.
- W2214717963 title "Microbial translocation and microbiome dysbiosis in HIV-associated immune activation" @default.
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