FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2214759451> ?p ?o ?g. }

• W2214759451 endingPage "e622" @default.
• W2214759451 startingPage "e622" @default.
• W2214759451 abstract "Characterizing the molecular mechanisms underlying the heritability of complex behavioral traits such as human anxiety remains a challenging endeavor for behavioral neuroscience. Copy-number variation (CNV) in the general transcription factor gene, GTF2I, located in the 7q11.23 chromosomal region that is hemideleted in Williams syndrome and duplicated in the 7q11.23 duplication syndrome (Dup7), is associated with gene-dose-dependent anxiety in mouse models and in both Williams syndrome and Dup7. Because of this recent preclinical and clinical identification of a genetic influence on anxiety, we examined whether sequence variation in GTF2I, specifically the single-nucleotide polymorphism rs2527367, interacts with trait and state anxiety to collectively impact neural response to anxiety-laden social stimuli. Two hundred and sixty healthy adults completed the Tridimensional Personality Questionnaire Harm Avoidance (HA) subscale, a trait measure of anxiety proneness, and underwent functional magnetic resonance imaging (fMRI) while matching aversive (fearful or angry) facial identity. We found an interaction between GTF2I allelic variations and HA that affects brain response: in individuals homozygous for the major allele, there was no correlation between HA and whole-brain response to aversive cues, whereas in heterozygotes and individuals homozygous for the minor allele, there was a positive correlation between HA sub-scores and a selective dorsolateral prefrontal cortex (DLPFC) responsivity during the processing of aversive stimuli. These results demonstrate that sequence variation in the GTF2I gene influences the relationship between trait anxiety and brain response to aversive social cues in healthy individuals, supporting a role for this neurogenetic mechanism in anxiety." @default.
• W2214759451 created "2016-06-24" @default.
• W2214759451 creator A5000973666 @default.
• W2214759451 creator A5006709227 @default.
• W2214759451 creator A5016858258 @default.
• W2214759451 creator A5026133127 @default.
• W2214759451 creator A5030704950 @default.
• W2214759451 creator A5043264677 @default.
• W2214759451 creator A5046298918 @default.
• W2214759451 creator A5051045178 @default.
• W2214759451 creator A5063018420 @default.
• W2214759451 creator A5071586130 @default.
• W2214759451 creator A5076122185 @default.
• W2214759451 date "2015-08-18" @default.
• W2214759451 modified "2023-10-16" @default.
• W2214759451 title "Variation in the Williams syndrome GTF2I gene and anxiety proneness interactively affect prefrontal cortical response to aversive stimuli" @default.
• W2214759451 cites W1553827588 @default.
• W2214759451 cites W1967996189 @default.
• W2214759451 cites W1973387221 @default.
• W2214759451 cites W1973604459 @default.
• W2214759451 cites W1973637576 @default.
• W2214759451 cites W1975808930 @default.
• W2214759451 cites W1979373680 @default.
• W2214759451 cites W1990877586 @default.
• W2214759451 cites W1993233338 @default.
• W2214759451 cites W1996190920 @default.
• W2214759451 cites W2001389318 @default.
• W2214759451 cites W2003376241 @default.
• W2214759451 cites W2012203722 @default.
• W2214759451 cites W2018013323 @default.
• W2214759451 cites W2019131194 @default.
• W2214759451 cites W2024050612 @default.
• W2214759451 cites W2028418962 @default.
• W2214759451 cites W2039730733 @default.
• W2214759451 cites W2044271964 @default.
• W2214759451 cites W2053098418 @default.
• W2214759451 cites W2059359883 @default.
• W2214759451 cites W2069040148 @default.
• W2214759451 cites W2091486882 @default.
• W2214759451 cites W2094821053 @default.
• W2214759451 cites W2103748523 @default.
• W2214759451 cites W2104097622 @default.
• W2214759451 cites W2110634897 @default.
• W2214759451 cites W2111769807 @default.
• W2214759451 cites W2134613655 @default.
• W2214759451 cites W2147351252 @default.
• W2214759451 cites W2152780761 @default.
• W2214759451 cites W2163678509 @default.
• W2214759451 cites W4252392275 @default.
• W2214759451 doi "https://doi.org/10.1038/tp.2015.98" @default.
• W2214759451 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4564573" @default.
• W2214759451 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26285132" @default.
• W2214759451 hasPublicationYear "2015" @default.
• W2214759451 type Work @default.
• W2214759451 sameAs 2214759451 @default.
• W2214759451 citedByCount "23" @default.
• W2214759451 countsByYear W22147594512016 @default.
• W2214759451 countsByYear W22147594512017 @default.
• W2214759451 countsByYear W22147594512018 @default.
• W2214759451 countsByYear W22147594512019 @default.
• W2214759451 countsByYear W22147594512020 @default.
• W2214759451 countsByYear W22147594512021 @default.
• W2214759451 countsByYear W22147594512022 @default.
• W2214759451 crossrefType "journal-article" @default.
• W2214759451 hasAuthorship W2214759451A5000973666 @default.
• W2214759451 hasAuthorship W2214759451A5006709227 @default.
• W2214759451 hasAuthorship W2214759451A5016858258 @default.
• W2214759451 hasAuthorship W2214759451A5026133127 @default.
• W2214759451 hasAuthorship W2214759451A5030704950 @default.
• W2214759451 hasAuthorship W2214759451A5043264677 @default.
• W2214759451 hasAuthorship W2214759451A5046298918 @default.
• W2214759451 hasAuthorship W2214759451A5051045178 @default.
• W2214759451 hasAuthorship W2214759451A5063018420 @default.
• W2214759451 hasAuthorship W2214759451A5071586130 @default.
• W2214759451 hasAuthorship W2214759451A5076122185 @default.
• W2214759451 hasBestOaLocation W22147594511 @default.
• W2214759451 hasConcept C118552586 @default.
• W2214759451 hasConcept C138496976 @default.
• W2214759451 hasConcept C15744967 @default.
• W2214759451 hasConcept C169760540 @default.
• W2214759451 hasConcept C169900460 @default.
• W2214759451 hasConcept C187288502 @default.
• W2214759451 hasConcept C2776582870 @default.
• W2214759451 hasConcept C2777545354 @default.
• W2214759451 hasConcept C2777845764 @default.
• W2214759451 hasConcept C2779226451 @default.
• W2214759451 hasConcept C2780508717 @default.
• W2214759451 hasConcept C2781195155 @default.
• W2214759451 hasConcept C2865642 @default.
• W2214759451 hasConcept C2910002191 @default.
• W2214759451 hasConcept C558461103 @default.
• W2214759451 hasConcept C70410870 @default.
• W2214759451 hasConcept C77805123 @default.
• W2214759451 hasConceptScore W2214759451C118552586 @default.
• W2214759451 hasConceptScore W2214759451C138496976 @default.
• W2214759451 hasConceptScore W2214759451C15744967 @default.
• W2214759451 hasConceptScore W2214759451C169760540 @default.
• W2214759451 hasConceptScore W2214759451C169900460 @default.

• next