FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2214765325> ?p ?o ?g. }

• W2214765325 abstract "Myosin II isoforms with varying mechanochemistry and filament size interact with filamentous actin (F-actin) networks to generate contractile forces in cells. How their properties control force production in environments with varying stiffness is poorly understood. Here, we incorporated literature values for properties of myosin II isoforms into a cross-bridge model. Similar actin gliding speeds and force-velocity curves expected from previous experiments were observed. Motor force output on an elastic load was regulated by two timescales--that of their attachment to F-actin, which varied sharply with the ensemble size, motor duty ratio, and external load, and that of force build up, which scaled with ensemble stall force, gliding speed, and load stiffness. While such regulation did not require force-dependent kinetics, the myosin catch bond produced positive feedback between attachment time and force to trigger switch-like transitions from short attachments and small forces to high force-generating runs at threshold parameter values. Parameters representing skeletal muscle myosin, non-muscle myosin IIB, and non-muscle myosin IIA revealed distinct regimes of behavior respectively: (1) large assemblies of fast, low-duty ratio motors rapidly build stable forces over a large range of environmental stiffness, (2) ensembles of slow, high-duty ratio motors serve as high-affinity cross-links with force build-up times that exceed physiological timescales, and (3) small assemblies of low-duty ratio motors operating at intermediate speeds may respond sharply to changes in mechanical context--at low forces or stiffness, they serve as low affinity cross-links but they can transition to effective force production via the positive feedback mechanism described above. These results reveal how myosin isoform properties may be tuned to produce force and respond to mechanical cues in their environment." @default.
• W2214765325 created "2016-06-24" @default.
• W2214765325 creator A5005425034 @default.
• W2214765325 creator A5068671796 @default.
• W2214765325 creator A5072112725 @default.
• W2214765325 creator A5084404604 @default.
• W2214765325 date "2014-04-12" @default.
• W2214765325 modified "2023-09-27" @default.
• W2214765325 title "Force generation by Myosin II Filaments in Compliant Networks" @default.
• W2214765325 cites W1561116581 @default.
• W2214765325 cites W1901823973 @default.
• W2214765325 cites W1965337436 @default.
• W2214765325 cites W1965380851 @default.
• W2214765325 cites W1966779855 @default.
• W2214765325 cites W1968409252 @default.
• W2214765325 cites W1969933847 @default.
• W2214765325 cites W1972506441 @default.
• W2214765325 cites W1984741430 @default.
• W2214765325 cites W1986197523 @default.
• W2214765325 cites W1992353872 @default.
• W2214765325 cites W1995615412 @default.
• W2214765325 cites W1996788494 @default.
• W2214765325 cites W2015223366 @default.
• W2214765325 cites W2018094651 @default.
• W2214765325 cites W2026145805 @default.
• W2214765325 cites W2030029307 @default.
• W2214765325 cites W2031099832 @default.
• W2214765325 cites W2032127615 @default.
• W2214765325 cites W2035207820 @default.
• W2214765325 cites W2037544758 @default.
• W2214765325 cites W2039727443 @default.
• W2214765325 cites W2042321087 @default.
• W2214765325 cites W2054635074 @default.
• W2214765325 cites W2059908035 @default.
• W2214765325 cites W2065850897 @default.
• W2214765325 cites W2068050924 @default.
• W2214765325 cites W2068812356 @default.
• W2214765325 cites W2071129408 @default.
• W2214765325 cites W2079339450 @default.
• W2214765325 cites W2085437800 @default.
• W2214765325 cites W2086061329 @default.
• W2214765325 cites W2087573052 @default.
• W2214765325 cites W2101030382 @default.
• W2214765325 cites W2117425975 @default.
• W2214765325 cites W2121492835 @default.
• W2214765325 cites W2122739844 @default.
• W2214765325 cites W2130103532 @default.
• W2214765325 cites W2136218667 @default.
• W2214765325 cites W2148454908 @default.
• W2214765325 cites W2162541026 @default.
• W2214765325 cites W2320068990 @default.
• W2214765325 cites W2328081473 @default.
• W2214765325 cites W789458867 @default.
• W2214765325 hasPublicationYear "2014" @default.
• W2214765325 type Work @default.
• W2214765325 sameAs 2214765325 @default.
• W2214765325 citedByCount "0" @default.
• W2214765325 crossrefType "posted-content" @default.
• W2214765325 hasAuthorship W2214765325A5005425034 @default.
• W2214765325 hasAuthorship W2214765325A5068671796 @default.
• W2214765325 hasAuthorship W2214765325A5072112725 @default.
• W2214765325 hasAuthorship W2214765325A5084404604 @default.
• W2214765325 hasConcept C104317684 @default.
• W2214765325 hasConcept C121332964 @default.
• W2214765325 hasConcept C12554922 @default.
• W2214765325 hasConcept C125705527 @default.
• W2214765325 hasConcept C160408235 @default.
• W2214765325 hasConcept C185592680 @default.
• W2214765325 hasConcept C20418707 @default.
• W2214765325 hasConcept C2779372316 @default.
• W2214765325 hasConcept C53345823 @default.
• W2214765325 hasConcept C55493867 @default.
• W2214765325 hasConcept C57879066 @default.
• W2214765325 hasConcept C6997183 @default.
• W2214765325 hasConcept C86803240 @default.
• W2214765325 hasConcept C93126451 @default.
• W2214765325 hasConcept C95444343 @default.
• W2214765325 hasConcept C97355855 @default.
• W2214765325 hasConceptScore W2214765325C104317684 @default.
• W2214765325 hasConceptScore W2214765325C121332964 @default.
• W2214765325 hasConceptScore W2214765325C12554922 @default.
• W2214765325 hasConceptScore W2214765325C125705527 @default.
• W2214765325 hasConceptScore W2214765325C160408235 @default.
• W2214765325 hasConceptScore W2214765325C185592680 @default.
• W2214765325 hasConceptScore W2214765325C20418707 @default.
• W2214765325 hasConceptScore W2214765325C2779372316 @default.
• W2214765325 hasConceptScore W2214765325C53345823 @default.
• W2214765325 hasConceptScore W2214765325C55493867 @default.
• W2214765325 hasConceptScore W2214765325C57879066 @default.
• W2214765325 hasConceptScore W2214765325C6997183 @default.
• W2214765325 hasConceptScore W2214765325C86803240 @default.
• W2214765325 hasConceptScore W2214765325C93126451 @default.
• W2214765325 hasConceptScore W2214765325C95444343 @default.
• W2214765325 hasConceptScore W2214765325C97355855 @default.
• W2214765325 hasLocation W22147653251 @default.
• W2214765325 hasOpenAccess W2214765325 @default.
• W2214765325 hasPrimaryLocation W22147653251 @default.
• W2214765325 hasRelatedWork W1610367184 @default.
• W2214765325 hasRelatedWork W1667451644 @default.
• W2214765325 hasRelatedWork W1983572701 @default.

• next