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• W2214801158 abstract "A series of glycitylamines, which were prepared in few steps from readily available carbohydrates, were tested for their ability to inhibit tuberculosis growth in an Alamar Blue BCG colourimetric assay. Several derivatives, including (2R,3R)-1-(hexadecylamine)pent-4-ene-2,3-diol, (2R,3R)-1-(hexadecylmethylamino)pent-4-ene-2,3-diol and 5-deoxy-5-hexadecylmethylamino-D-arabinitol, were prepared in good to excellent (44-90%) overall yield and exhibited micromolar (20-41μM) inhibitory activity that was similar to the first line tuberculosis (TB) drug ethambutol (39μM) in the same assay. The ease and low cost of the synthesis of the glycitylamines offers definite advantages for their use as potential TB drugs." @default.
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• W2214801158 date "2016-02-01" @default.
• W2214801158 modified "2023-09-24" @default.
• W2214801158 title "Synthesis and anti-tuberculosis activity of glycitylamines" @default.
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• W2214801158 doi "https://doi.org/10.1016/j.bmc.2015.12.036" @default.
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