Matches in SemOpenAlex for { <https://semopenalex.org/work/W2214857597> ?p ?o ?g. }
Showing items 1 to 60 of
60
with 100 items per page.
- W2214857597 abstract "Background: MND has been identified as a degenerative axonal brain disease with focus on upper and lower motor neurons. A high amount of neurons have to be affected before clinical symptoms occur. Our hypothesis is that regional spots of subclinical atrophy can be identified with quantitative routine MRI.Materials/methods: The design of this pilot study is controlled, prospective and blinded. 5 consecutive patients with a proved diagnosis of MND were enrolled. 3 had bulbar symptoms. 27 healthy subjects served as a normative database. The clinical assessment was paralleled with a 3T MRI examination, including a high resolution T1 sequence (MPRAGE). All MRI data were normalized to a stereotactical space followed by a segmentation algorythm and a voxel wise two sample T test checking each patient and the normative database for any volume deviations. The 3D atrophy maps were analysed for each patient and detected for MND specific patterns.Results: All patients revealed spots of regional White matter (WM) atrophy mainly in the Corpus callosum, cerebellum, pyramidal tract, especially in the brainstem. Single spots of regional brain atrophy were found in the gray matter (GM) of the occipital and temporal lobe and Hippocampus. The brain parenchym fraction, GM and WM volumes were normal.Conclusions: Our data confirms findings suggesting MND not only restricted to a motor neuron degeneration. Furthermore the presented method is applicable as a surrogate marker for axonal degeneration in MND, supporting diagnosis and monitoring. We suggest to take this quantitative tool into account for treatment studies. Disclosure: Dr. Winkler has nothing to disclose. Dr. Raji has nothing to disclose. Dr. Opfer has nothing to disclose. Dr. Spies has nothing to disclose." @default.
- W2214857597 created "2016-06-24" @default.
- W2214857597 creator A5047876493 @default.
- W2214857597 creator A5057079579 @default.
- W2214857597 creator A5063144437 @default.
- W2214857597 creator A5067351162 @default.
- W2214857597 date "2015-04-06" @default.
- W2214857597 modified "2023-09-23" @default.
- W2214857597 title "Regional brain atrophy in MND as a diagnostic marker derived by routine high resolution MRI. (P6.023)" @default.
- W2214857597 hasPublicationYear "2015" @default.
- W2214857597 type Work @default.
- W2214857597 sameAs 2214857597 @default.
- W2214857597 citedByCount "0" @default.
- W2214857597 crossrefType "journal-article" @default.
- W2214857597 hasAuthorship W2214857597A5047876493 @default.
- W2214857597 hasAuthorship W2214857597A5057079579 @default.
- W2214857597 hasAuthorship W2214857597A5063144437 @default.
- W2214857597 hasAuthorship W2214857597A5067351162 @default.
- W2214857597 hasConcept C126838900 @default.
- W2214857597 hasConcept C142724271 @default.
- W2214857597 hasConcept C143409427 @default.
- W2214857597 hasConcept C200134340 @default.
- W2214857597 hasConcept C2778183499 @default.
- W2214857597 hasConcept C2781172350 @default.
- W2214857597 hasConcept C2781192897 @default.
- W2214857597 hasConcept C71924100 @default.
- W2214857597 hasConceptScore W2214857597C126838900 @default.
- W2214857597 hasConceptScore W2214857597C142724271 @default.
- W2214857597 hasConceptScore W2214857597C143409427 @default.
- W2214857597 hasConceptScore W2214857597C200134340 @default.
- W2214857597 hasConceptScore W2214857597C2778183499 @default.
- W2214857597 hasConceptScore W2214857597C2781172350 @default.
- W2214857597 hasConceptScore W2214857597C2781192897 @default.
- W2214857597 hasConceptScore W2214857597C71924100 @default.
- W2214857597 hasOpenAccess W2214857597 @default.
- W2214857597 hasRelatedWork W1520259015 @default.
- W2214857597 hasRelatedWork W1531694727 @default.
- W2214857597 hasRelatedWork W1600907624 @default.
- W2214857597 hasRelatedWork W1832900872 @default.
- W2214857597 hasRelatedWork W1981146695 @default.
- W2214857597 hasRelatedWork W2045155191 @default.
- W2214857597 hasRelatedWork W2051597264 @default.
- W2214857597 hasRelatedWork W2113362178 @default.
- W2214857597 hasRelatedWork W2127256277 @default.
- W2214857597 hasRelatedWork W2145035124 @default.
- W2214857597 hasRelatedWork W2215493432 @default.
- W2214857597 hasRelatedWork W2381685988 @default.
- W2214857597 hasRelatedWork W2391222442 @default.
- W2214857597 hasRelatedWork W2467883486 @default.
- W2214857597 hasRelatedWork W2899881225 @default.
- W2214857597 hasRelatedWork W2928337083 @default.
- W2214857597 hasRelatedWork W3034392317 @default.
- W2214857597 hasRelatedWork W3199522954 @default.
- W2214857597 hasRelatedWork W3202482181 @default.
- W2214857597 hasRelatedWork W409295466 @default.
- W2214857597 hasVolume "84" @default.
- W2214857597 isParatext "false" @default.
- W2214857597 isRetracted "false" @default.
- W2214857597 magId "2214857597" @default.
- W2214857597 workType "article" @default.