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• W221489722 startingPage "109" @default.
• W221489722 abstract "Tumour necrosis factor (TNF), a lymphokine released by activated macrophages, has diverse effects on a wide variety of cell types. TNF exerts these effects via specific cell surface receptors; however little is known of the biochemical events that ensue. We have shown that TNF rapidly induces the proto-oncogenes c-fos and c-jun in the adipogenic TA1 cell line and have used these responses to characterize the intracellular mediators of TNF action. We find that arachidonic acid, which is released in response to TNF, induces c-fos, but not c-jun mRNA in quiescent TA1 cells. Pretreatment of the cells with lipoxygenase inhibitors abolishes the induction of c-fos by TNF, while the induction of c-jun is unaffected; in contrast, a cyclooxygenase inhibitor has no effect on either response. Finally, we have demonstrated that TNF stimulates production of lipoxygenase metabolites in TA1 cells and that one of these, 5-HPETE, induces c-fos, but not c-jun. These data suggest that TNF activates two second messenger pathways, one of which is dependent on release of arachidonic acid and its subsequent conversion to a lipoxygenase metabolite." @default.
• W221489722 created "2016-06-24" @default.
• W221489722 creator A5014513827 @default.
• W221489722 creator A5086229346 @default.
• W221489722 creator A5058515689 @default.
• W221489722 date "1991-01-01" @default.
• W221489722 modified "2023-09-26" @default.
• W221489722 title "TNF induces c-fos via a novel pathway requiring conversion of arachidonic acid to a lipoxygenase metabolite." @default.
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• W221489722 doi "https://doi.org/10.1002/j.1460-2075.1991.tb07926.x" @default.
• W221489722 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/452618" @default.
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• W221489722 hasPublicationYear "1991" @default.
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