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- W2214906227 abstract "In this work, a new conjugated polymer poly(fluorene-co-phenylene) derivative containing pendent quaternized chlormethine (PFP-Chl) was synthesized by covalent linking small molecular prodrug groups onto conjugated polymer side chains. H2O2-sensitive prodrug with an eight-member-cyclic boronate ester structure could suffer from H2O2-triggered nitrogen mustard release and further DNA cross-linking and alkylation. PFP-Chl combines therapeutic characteristic with excellent optical property of conjugated polymers. It is found that PFP-Chl could enter into cells by endocytosis to simultaneously exhibit abilities of fluorescent imaging and tumor cell inhibition." @default.
- W2214906227 created "2016-06-24" @default.
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- W2214906227 date "2016-01-04" @default.
- W2214906227 modified "2023-10-09" @default.
- W2214906227 title "Preparation of Conjugated Polymer Grafted with H<sub>2</sub>O<sub>2</sub>-Sensitive Prodrug for Cell Imaging and Tumor Cell Killing" @default.
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- W2214906227 doi "https://doi.org/10.1021/acsami.5b11846" @default.
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