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- W2214908017 abstract "Galectin-1 (Gal-1), a member of the mammalian lectins, recognizes galactose-containing sequences of oligosaccharides associated with several cell surface glycoconjugates. Gal-1 recognizes appropriate glycoepitopes on human breast cancer cells. Gal-1 is expressed in many malignant and normal tissues. Furthermore, it is known that Gal-1 can initiate T cell apoptosis. The Thomsen-Friedenreich (TF) antigen is a specific oncofetal carbohydrate epitope (Galβ1–3GalNAcα-O epitope) expressed on the surface of various carcinomas. It mediates endothelium adhesion and tumor invasion and could thus be a marker of aggressiveness. As it also causes an immune response, it is an interesting target for the development of therapeutic antibodies. Mucin derives from the word mucus and designates the structural component of it. The O-glycans are involved in antigen binding and/or signal transduction. Mucins are divided into 2 groups: membrane-bound ones such as mucin-1 (MUC1) and secreted mucins. MUC1 plays a role in the barrier function of the mucous membranes and helps regulate cell adhesion. In gynecologic cancer tissue, MUC1 is glycosylated with the TF epitope. Gal-1 is able to bind to the TF epitope attached to MUC1. Gal-1, TF, and MUC1 are interesting targets for novel and specific antibody therapies in gynecologic cancer therapies." @default.
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- W2214908017 date "2011-01-01" @default.
- W2214908017 modified "2023-10-16" @default.
- W2214908017 title "Galectins, Glycans, and Mucins as Targets for Novel and Specific Antibody Therapies in Gynecologic Cancer Therapies" @default.
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- W2214908017 doi "https://doi.org/10.1159/000328906" @default.
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