Matches in SemOpenAlex for { <https://semopenalex.org/work/W2214962513> ?p ?o ?g. }
- W2214962513 endingPage "126" @default.
- W2214962513 startingPage "117" @default.
- W2214962513 abstract "Dopamine cell firing can encode errors in reward prediction, providing a learning signal to guide future behavior. Yet dopamine is also a key modulator of motivation, invigorating current behavior. Existing theories propose that fast (phasic) dopamine fluctuations support learning, whereas much slower (tonic) dopamine changes are involved in motivation. We examined dopamine release in the nucleus accumbens across multiple time scales, using complementary microdialysis and voltammetric methods during adaptive decision-making. We found that minute-by-minute dopamine levels covaried with reward rate and motivational vigor. Second-by-second dopamine release encoded an estimate of temporally discounted future reward (a value function). Changing dopamine immediately altered willingness to work and reinforced preceding action choices by encoding temporal-difference reward prediction errors. Our results indicate that dopamine conveys a single, rapidly evolving decision variable, the available reward for investment of effort, which is employed for both learning and motivational functions." @default.
- W2214962513 created "2016-06-24" @default.
- W2214962513 creator A5002338541 @default.
- W2214962513 creator A5012167472 @default.
- W2214962513 creator A5017533419 @default.
- W2214962513 creator A5018737747 @default.
- W2214962513 creator A5038672883 @default.
- W2214962513 creator A5050466159 @default.
- W2214962513 creator A5056086091 @default.
- W2214962513 creator A5063666386 @default.
- W2214962513 creator A5086992454 @default.
- W2214962513 date "2015-11-23" @default.
- W2214962513 modified "2023-10-10" @default.
- W2214962513 title "Mesolimbic dopamine signals the value of work" @default.
- W2214962513 cites W1508550656 @default.
- W2214962513 cites W1515543691 @default.
- W2214962513 cites W1601553256 @default.
- W2214962513 cites W1968490092 @default.
- W2214962513 cites W1969089145 @default.
- W2214962513 cites W1975900334 @default.
- W2214962513 cites W1979215131 @default.
- W2214962513 cites W1983408848 @default.
- W2214962513 cites W1986719333 @default.
- W2214962513 cites W1989637315 @default.
- W2214962513 cites W1991756001 @default.
- W2214962513 cites W1992842416 @default.
- W2214962513 cites W1993407225 @default.
- W2214962513 cites W1994997661 @default.
- W2214962513 cites W1995214286 @default.
- W2214962513 cites W1995915560 @default.
- W2214962513 cites W1997978210 @default.
- W2214962513 cites W2001643038 @default.
- W2214962513 cites W2006204133 @default.
- W2214962513 cites W2006608250 @default.
- W2214962513 cites W2009831159 @default.
- W2214962513 cites W2011451766 @default.
- W2214962513 cites W2014610415 @default.
- W2214962513 cites W2019310225 @default.
- W2214962513 cites W2023916971 @default.
- W2214962513 cites W2026114953 @default.
- W2214962513 cites W2029164808 @default.
- W2214962513 cites W2029383690 @default.
- W2214962513 cites W2030948095 @default.
- W2214962513 cites W2042390755 @default.
- W2214962513 cites W2042420303 @default.
- W2214962513 cites W2046479615 @default.
- W2214962513 cites W2055523610 @default.
- W2214962513 cites W2055963704 @default.
- W2214962513 cites W2069441590 @default.
- W2214962513 cites W2069454391 @default.
- W2214962513 cites W2072630058 @default.
- W2214962513 cites W2073602092 @default.
- W2214962513 cites W2075994330 @default.
- W2214962513 cites W2076256116 @default.
- W2214962513 cites W2076625068 @default.
- W2214962513 cites W2080790162 @default.
- W2214962513 cites W2087148726 @default.
- W2214962513 cites W2092861175 @default.
- W2214962513 cites W2096839627 @default.
- W2214962513 cites W2108023589 @default.
- W2214962513 cites W2113616846 @default.
- W2214962513 cites W2114520249 @default.
- W2214962513 cites W2116085129 @default.
- W2214962513 cites W2116257195 @default.
- W2214962513 cites W2117726420 @default.
- W2214962513 cites W2130086055 @default.
- W2214962513 cites W2137740474 @default.
- W2214962513 cites W2137930004 @default.
- W2214962513 cites W2144534164 @default.
- W2214962513 cites W2147538742 @default.
- W2214962513 cites W2148228571 @default.
- W2214962513 cites W2149878007 @default.
- W2214962513 cites W2158420012 @default.
- W2214962513 cites W2158972787 @default.
- W2214962513 cites W2163773342 @default.
- W2214962513 cites W2163805252 @default.
- W2214962513 cites W2164961539 @default.
- W2214962513 cites W2165706889 @default.
- W2214962513 cites W2165743581 @default.
- W2214962513 cites W2170841047 @default.
- W2214962513 cites W4214717370 @default.
- W2214962513 doi "https://doi.org/10.1038/nn.4173" @default.
- W2214962513 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4696912" @default.
- W2214962513 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26595651" @default.
- W2214962513 hasPublicationYear "2015" @default.
- W2214962513 type Work @default.
- W2214962513 sameAs 2214962513 @default.
- W2214962513 citedByCount "612" @default.
- W2214962513 countsByYear W22149625132015 @default.
- W2214962513 countsByYear W22149625132016 @default.
- W2214962513 countsByYear W22149625132017 @default.
- W2214962513 countsByYear W22149625132018 @default.
- W2214962513 countsByYear W22149625132019 @default.
- W2214962513 countsByYear W22149625132020 @default.
- W2214962513 countsByYear W22149625132021 @default.
- W2214962513 countsByYear W22149625132022 @default.
- W2214962513 countsByYear W22149625132023 @default.
- W2214962513 crossrefType "journal-article" @default.