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• W2214971289 abstract "Diagnosis of Parkinson's disease dementia is a challenge in clinical settings. A comprehensive neuropsychological evaluation is time-consuming and expensive; brief instruments for cognitive evaluation must be easier to administer and provide a reliable classification.To study the validity of the Brazilian version of Addenbrooke's Cognitive Examination-Revised (ACE-R) for the cognitive assessment of Parkinson's disease (PD) patients with heterogeneous educational level.Patients were evaluated according to the diagnostic procedures recommended by the Movement Disorder Society (MDS) as the gold standard for the diagnosis of dementia in PD.We studied 70 idiopathic PD patients, with a mean (SD) age of 64.1 (9.3) years and mean disease duration of 7.7 (5.3) years and educational level of 5.9 years, matched for education and age to controls. Twenty-seven patients fulfilled MDS clinical criteria for PD dementia. Mean scores on the ACE-R were 54.7 (12.8) points for patients with PD dementia, 76 (9.9) for PD patients without dementia and 79.7 (1.8) points for healthy controls. The area under the receiver operating curve, taking the MDS diagnostic procedures as a reference, was 0.93 [95% CI, 0.87-0.98; p<0.001] for ACE-R. The optimal cut-off value for ACE-R was ≤72 points [sensitivity 90%; specificity 85%; Kappa concordance (K) 0.79].ACE-R appears to be a valid tool for dementia evaluation in PD patients with heterogeneous educational level, displaying good correlation with clinical criteria and diagnostic procedures of the MDS.O diagnóstico da demência na doença de Pakinson é desafiador na prática clínica. A avaliação neuropsicológica ampla é cara e demorada; instrumentos breves para avaliação cognitiva devem ser fáceis de realizar e fornecer uma classificação confiável.Estudar a validade da versão Brasileira do Addenbrooke's Cognitive Examination-Revised (ACE-R) para a avaliação em pacientes com doença de Parkinson (DP) com nível de escolaridade heterogêneo.Os pacientes foram avaliados segundo os procedimentos diagnósticos recomendados pela Movement Disorder Society (MDS) como padrão ouro para diagnóstico de demência da DP (DDP).Nós estudamos 70 pacientes com DP idiopática, pareados por idade e escolaridade a controles, com média de idade de 64,1 (9,3) anos, tempo médio de doença de 7,7 (5,3) anos e nível educacional de 5,9 anos. Vinte e sete pacientes preencheram critério da MDS para DDP. Os escores médios na ACE-R foram de 54,7 (12,8) pontos para DDP, 76 (9,9) para DP sem demência e 79,7 (1,8) pontos para os controles saudáveis. A área sob a curva tomando-se os procedimentos diagnósticos da MDS como referência foi 0,93 [95% CI, 0,87-0,98; p<0,001] para ACE-R. O melhor escore de corte foi de ≤72 pontos (sensibilidade de 90% e especificidade de 85%; Kappa concordance (K) 0.79).A ACE-R parece ser um instrumento válido para avaliação de demência em pacientes com DP de níveis educacionais heterogêneos, mostrando boa correlação com o critério clínico e procedimentos diagnósticos da MDS." @default.
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• W2214971289 date "2014-03-01" @default.
• W2214971289 modified "2023-10-17" @default.
• W2214971289 title "Addenbrooke's Cognitive Examination-Revised is accurate for detecting dementia in Parkinson's disease patients with low educational level" @default.
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• W2214971289 doi "https://doi.org/10.1590/s1980-57642014dn81000004" @default.
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