Matches in SemOpenAlex for { <https://semopenalex.org/work/W2214971944> ?p ?o ?g. }
- W2214971944 endingPage "130" @default.
- W2214971944 startingPage "130" @default.
- W2214971944 abstract "Males have a higher incidence of renal cell carcinoma (RCC) than females, but the reason for this gender difference is unknown. Addressing this question, we report the discovery of an androgen receptor (AR)- induced HIF2a/VEGF signal that drives RCC progression. AR attenuation or augmentation in RCC cells altered their proliferation, migration, and invasion in multiple models in vitro and in vivo. Mechanistic investigations revealed that AR targeting inhibited RCC cell migration and invasion by modulating HIF2a/ VEGF signals at the level of mRNA and protein expression. Interrupting HIF2a/VEGF signals with inhibitors of either HIF2a or VEGF was sufficient to suppress RCC progression. Similarly, the specific AR degradation enhancer ASC-J9 was sufficient to suppress AR-induced HIF2a/VEGF signaling and RCC progression in multiple models in vitro and in vivo. Taken together, our results revealed a novel role for AR in RCC initiation and progression with implications for novel therapeutic strategies. Cancer Res; 74(16); 4420-30. � 2014 AACR." @default.
- W2214971944 created "2016-06-24" @default.
- W2214971944 creator A5025595895 @default.
- W2214971944 creator A5026456311 @default.
- W2214971944 creator A5041721692 @default.
- W2214971944 creator A5042617541 @default.
- W2214971944 creator A5048081746 @default.
- W2214971944 creator A5052134746 @default.
- W2214971944 creator A5067242485 @default.
- W2214971944 creator A5080563033 @default.
- W2214971944 creator A5086783805 @default.
- W2214971944 date "2014-12-09" @default.
- W2214971944 modified "2023-09-22" @default.
- W2214971944 title "AB130. ASC-J9 suppresses renal cell carcinoma progression by targeting an androgen receptor-dependent HIF2α/VEGF signaling pathway." @default.
- W2214971944 cites W1524155094 @default.
- W2214971944 cites W1543329772 @default.
- W2214971944 cites W1572455728 @default.
- W2214971944 cites W1882606371 @default.
- W2214971944 cites W1902994240 @default.
- W2214971944 cites W1965700681 @default.
- W2214971944 cites W1967453449 @default.
- W2214971944 cites W1989903220 @default.
- W2214971944 cites W1996810856 @default.
- W2214971944 cites W2007280943 @default.
- W2214971944 cites W2009318525 @default.
- W2214971944 cites W2012512189 @default.
- W2214971944 cites W2013818100 @default.
- W2214971944 cites W2029598464 @default.
- W2214971944 cites W2035429495 @default.
- W2214971944 cites W2041881143 @default.
- W2214971944 cites W2042349351 @default.
- W2214971944 cites W2049838693 @default.
- W2214971944 cites W2064293531 @default.
- W2214971944 cites W2105677187 @default.
- W2214971944 cites W2117502057 @default.
- W2214971944 cites W2118396369 @default.
- W2214971944 cites W2120220319 @default.
- W2214971944 cites W2127458009 @default.
- W2214971944 cites W2134555283 @default.
- W2214971944 cites W2134690947 @default.
- W2214971944 cites W2135139265 @default.
- W2214971944 cites W2137643749 @default.
- W2214971944 cites W2152677478 @default.
- W2214971944 cites W2165241118 @default.
- W2214971944 cites W2243163642 @default.
- W2214971944 cites W2470040826 @default.
- W2214971944 cites W2470466748 @default.
- W2214971944 doi "https://doi.org/10.3978/j.issn.2223-4683.2014.s130" @default.
- W2214971944 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4708530" @default.
- W2214971944 hasPublicationYear "2014" @default.
- W2214971944 type Work @default.
- W2214971944 sameAs 2214971944 @default.
- W2214971944 citedByCount "0" @default.
- W2214971944 crossrefType "journal-article" @default.
- W2214971944 hasAuthorship W2214971944A5025595895 @default.
- W2214971944 hasAuthorship W2214971944A5026456311 @default.
- W2214971944 hasAuthorship W2214971944A5041721692 @default.
- W2214971944 hasAuthorship W2214971944A5042617541 @default.
- W2214971944 hasAuthorship W2214971944A5048081746 @default.
- W2214971944 hasAuthorship W2214971944A5052134746 @default.
- W2214971944 hasAuthorship W2214971944A5067242485 @default.
- W2214971944 hasAuthorship W2214971944A5080563033 @default.
- W2214971944 hasAuthorship W2214971944A5086783805 @default.
- W2214971944 hasConcept C121608353 @default.
- W2214971944 hasConcept C126322002 @default.
- W2214971944 hasConcept C185592680 @default.
- W2214971944 hasConcept C207001950 @default.
- W2214971944 hasConcept C2777472916 @default.
- W2214971944 hasConcept C2779256057 @default.
- W2214971944 hasConcept C2780192828 @default.
- W2214971944 hasConcept C502942594 @default.
- W2214971944 hasConcept C54355233 @default.
- W2214971944 hasConcept C61367390 @default.
- W2214971944 hasConcept C62478195 @default.
- W2214971944 hasConcept C71924100 @default.
- W2214971944 hasConcept C86803240 @default.
- W2214971944 hasConcept C95444343 @default.
- W2214971944 hasConceptScore W2214971944C121608353 @default.
- W2214971944 hasConceptScore W2214971944C126322002 @default.
- W2214971944 hasConceptScore W2214971944C185592680 @default.
- W2214971944 hasConceptScore W2214971944C207001950 @default.
- W2214971944 hasConceptScore W2214971944C2777472916 @default.
- W2214971944 hasConceptScore W2214971944C2779256057 @default.
- W2214971944 hasConceptScore W2214971944C2780192828 @default.
- W2214971944 hasConceptScore W2214971944C502942594 @default.
- W2214971944 hasConceptScore W2214971944C54355233 @default.
- W2214971944 hasConceptScore W2214971944C61367390 @default.
- W2214971944 hasConceptScore W2214971944C62478195 @default.
- W2214971944 hasConceptScore W2214971944C71924100 @default.
- W2214971944 hasConceptScore W2214971944C86803240 @default.
- W2214971944 hasConceptScore W2214971944C95444343 @default.
- W2214971944 hasLocation W22149719441 @default.
- W2214971944 hasOpenAccess W2214971944 @default.
- W2214971944 hasPrimaryLocation W22149719441 @default.
- W2214971944 hasRelatedWork W1992140459 @default.
- W2214971944 hasRelatedWork W1999618694 @default.
- W2214971944 hasRelatedWork W2054519162 @default.
- W2214971944 hasRelatedWork W2112202844 @default.