FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2214981143> ?p ?o ?g. }

• W2214981143 endingPage "1048" @default.
• W2214981143 startingPage "1043" @default.
• W2214981143 abstract "To study the effect of low intensity pulsed ultrasound (LIPUS) on the expression of tissue inhibitor of metalloproteinase-2 (TIMP-2) in the serum and expression of matrix metallopeptidase 13 (MMP-13) in the articular cartilage cells of rabbits with knee osteoarthritis (OA). Inner patellar ligament defect method was used to establish the model of knee OA. Four weeks after the modeling, the arterial blood was drawn from the ear of each rabbit, while ELISA was employed to detect the expression of TIMP-2 in the serum. The chondrocytes were separated from animals in each group and then cultured in vitro. All rabbits were divided into control group, OA model group and OA + LIPUS group. Cells in the control and OA groups were not treated, while cells in the OA + LIPUS group were treated with LIPUS (40 mW/cm2, 1 time/day). Cells were collected 7 d later and the RNA and total protein were extracted respectively. Real-time PCR and Western blotting were employed to analyze the expression of MMP-13 in chondrocytes at the mRNA and protein level, respectively. The success rate of establishment of OA model was 83%. The results of ELISA showed that the content of TIMP-2 in the serum of animals with OA was 22.3%, lower than the one in the control group (P < 0.05). Compared with the normal control group, the expression of TIMP-2 in the OA model group was significantly increased, while the expression of MMP-13 was significantly increased (P < 0.05). After the stimulation of LIPUS, the expression of TIMP-2 and MMP-13 was close to the one in the normal control group. The inner patellar ligament defect method is a mature method to establish the rabbit OA model, with high success rate. The expression of serum TIMP-2 in the OA model group is significantly decreased. LIPUS can up-regulate TIMP-2 and down-regulate MMP-13." @default.
• W2214981143 created "2016-06-24" @default.
• W2214981143 creator A5000963958 @default.
• W2214981143 creator A5020147975 @default.
• W2214981143 creator A5023996199 @default.
• W2214981143 creator A5073000374 @default.
• W2214981143 creator A5083774882 @default.
• W2214981143 date "2015-12-01" @default.
• W2214981143 modified "2023-09-27" @default.
• W2214981143 title "Effect of low intensity pulsed ultrasound on expression of TIMP-2 in serum and expression of mmp-13 in articular cartilage of rabbits with knee osteoarthritis" @default.
• W2214981143 cites W1966615243 @default.
• W2214981143 cites W2016232919 @default.
• W2214981143 cites W2043374776 @default.
• W2214981143 cites W2045481383 @default.
• W2214981143 cites W2049153686 @default.
• W2214981143 cites W2077657344 @default.
• W2214981143 cites W2077848818 @default.
• W2214981143 cites W2088014008 @default.
• W2214981143 cites W2105901945 @default.
• W2214981143 cites W2132126144 @default.
• W2214981143 cites W2145067682 @default.
• W2214981143 cites W2147443909 @default.
• W2214981143 cites W2159225077 @default.
• W2214981143 cites W2169871930 @default.
• W2214981143 doi "https://doi.org/10.1016/j.apjtm.2015.11.003" @default.
• W2214981143 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26706677" @default.
• W2214981143 hasPublicationYear "2015" @default.
• W2214981143 type Work @default.
• W2214981143 sameAs 2214981143 @default.
• W2214981143 citedByCount "14" @default.
• W2214981143 countsByYear W22149811432016 @default.
• W2214981143 countsByYear W22149811432017 @default.
• W2214981143 countsByYear W22149811432018 @default.
• W2214981143 countsByYear W22149811432020 @default.
• W2214981143 countsByYear W22149811432022 @default.
• W2214981143 countsByYear W22149811432023 @default.
• W2214981143 crossrefType "journal-article" @default.
• W2214981143 hasAuthorship W2214981143A5000963958 @default.
• W2214981143 hasAuthorship W2214981143A5020147975 @default.
• W2214981143 hasAuthorship W2214981143A5023996199 @default.
• W2214981143 hasAuthorship W2214981143A5073000374 @default.
• W2214981143 hasAuthorship W2214981143A5083774882 @default.
• W2214981143 hasBestOaLocation W22149811431 @default.
• W2214981143 hasConcept C104317684 @default.
• W2214981143 hasConcept C105580179 @default.
• W2214981143 hasConcept C105702510 @default.
• W2214981143 hasConcept C106487976 @default.
• W2214981143 hasConcept C109523444 @default.
• W2214981143 hasConcept C126322002 @default.
• W2214981143 hasConcept C126838900 @default.
• W2214981143 hasConcept C142724271 @default.
• W2214981143 hasConcept C143753070 @default.
• W2214981143 hasConcept C16685009 @default.
• W2214981143 hasConcept C185592680 @default.
• W2214981143 hasConcept C204787440 @default.
• W2214981143 hasConcept C2776164576 @default.
• W2214981143 hasConcept C2778232976 @default.
• W2214981143 hasConcept C2778434673 @default.
• W2214981143 hasConcept C2778550726 @default.
• W2214981143 hasConcept C2779727089 @default.
• W2214981143 hasConcept C2780550940 @default.
• W2214981143 hasConcept C2780766565 @default.
• W2214981143 hasConcept C2991944018 @default.
• W2214981143 hasConcept C43617362 @default.
• W2214981143 hasConcept C55493867 @default.
• W2214981143 hasConcept C71924100 @default.
• W2214981143 hasConcept C85265743 @default.
• W2214981143 hasConceptScore W2214981143C104317684 @default.
• W2214981143 hasConceptScore W2214981143C105580179 @default.
• W2214981143 hasConceptScore W2214981143C105702510 @default.
• W2214981143 hasConceptScore W2214981143C106487976 @default.
• W2214981143 hasConceptScore W2214981143C109523444 @default.
• W2214981143 hasConceptScore W2214981143C126322002 @default.
• W2214981143 hasConceptScore W2214981143C126838900 @default.
• W2214981143 hasConceptScore W2214981143C142724271 @default.
• W2214981143 hasConceptScore W2214981143C143753070 @default.
• W2214981143 hasConceptScore W2214981143C16685009 @default.
• W2214981143 hasConceptScore W2214981143C185592680 @default.
• W2214981143 hasConceptScore W2214981143C204787440 @default.
• W2214981143 hasConceptScore W2214981143C2776164576 @default.
• W2214981143 hasConceptScore W2214981143C2778232976 @default.
• W2214981143 hasConceptScore W2214981143C2778434673 @default.
• W2214981143 hasConceptScore W2214981143C2778550726 @default.
• W2214981143 hasConceptScore W2214981143C2779727089 @default.
• W2214981143 hasConceptScore W2214981143C2780550940 @default.
• W2214981143 hasConceptScore W2214981143C2780766565 @default.
• W2214981143 hasConceptScore W2214981143C2991944018 @default.
• W2214981143 hasConceptScore W2214981143C43617362 @default.
• W2214981143 hasConceptScore W2214981143C55493867 @default.
• W2214981143 hasConceptScore W2214981143C71924100 @default.
• W2214981143 hasConceptScore W2214981143C85265743 @default.
• W2214981143 hasIssue "12" @default.
• W2214981143 hasLocation W22149811431 @default.
• W2214981143 hasLocation W22149811432 @default.
• W2214981143 hasOpenAccess W2214981143 @default.
• W2214981143 hasPrimaryLocation W22149811431 @default.
• W2214981143 hasRelatedWork W1992931301 @default.
• W2214981143 hasRelatedWork W2044764337 @default.

• next