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- W2215076500 abstract "To evaluate an appropriate planning target volume (PTV) margin in for one to three vertebral metastases using megavolt computed tomography (MVCT) images during the course of image-guided and stereotactic intensity-modulated radiotherapy (IGRT-IMRT) by use of helical tomotherapy.A total of 25 lesions in 24 patients with vertebral metastases who received IGRT-IMRT were analyzed. MVCT images were acquired before and after radiation therapy. Intra-fractional movement and PTV margin were calculated by comparing treatment planning images and these 310 MVCT images for right-left (RL), superior-inferior (SI), and anteroposterior (AP) dimensions. Five patients were treated by 35 Gy/5 fractions, 17 by 30 Gy/5 fractions, one by 25 Gy/5 fractions, and one by 60 Gy/30 fractions. A margin to compensate for these variations was calculated with the formula of vanHerk's equation.The intra-fractional motion was 0.02 (-1.3 to 1.4) ± 0.34 mm in the RL direction, -0.09 (-1.8 to 0.28) ± 0.44 mm in the SI direction, and 0.20 (-1.8 to 1.8) ± 0.36 mm in the AP direction. The required PTV margin was 0.98 mm in the RL direction, 0.69 mm in the SI direction, and 1.26 mm in the AP direction. No patient showed a deviation greater than 2 mm.The PTV margin in hypofractionated IGRT-IMRT, using helical tomotherapy for a few vertebral metastases, was 2 mm or less and our tentative PTV margin of 5 mm was sufficient and reducible." @default.
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- W2215076500 date "2013-06-01" @default.
- W2215076500 modified "2023-10-01" @default.
- W2215076500 title "Assessment of planning target volume margin for a small number of vertebral metastatic lesions using image-guided intensity-modulated radiation therapy by helical tomotherapy." @default.
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