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- W2215133048 abstract "Glucosamine is a widely used supplement among patients with osteoarthritis. Also, it has been shown that glucosamine exhibits anti-inflammatory action through the suppression of neutrophil activation. In this study, efficacy of glucosamine supplementation to attenuates DSS-induced colitis. C57BL/6 mice were separated into three groups (n=10/group). ND group was fed control diet. LGS and HGS groups were fed diet supplemented with either 0.05% (w/w) or 0.1% (w/w) glucosamine sulfate for 4 weeks, respectively. Two weeks after feeding experiment diet, colitis was induced by supplying two cycles (5 days per cycle) of 2% DSS drinking water. Two cycles were separated by 7 days. Study results indicated that HGS group showed improvement in clinical symptoms measured by disease activity index. The expression of tight junction proteins including ZO-1 and occludin was significantly higher in HGS group compared to those of animals in other groups. ND group had significantly reduced colon length (p<0.05), while HGS group reversed DSS-induced shortening of the colon (p<0.05). HGS group exhibited significantly decreased serum concentrations of both interleukin-8 (IL-8) by 52% and serum amyloid P component (SAP) by 55% (p<0.05). In addition, the colonic mucosa tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) mRNA expression was markedly reduced in HGS group compared with those of the ND group at p<.0001, and at p<0.05, respectively. Also, the colonic protein expression of lipocalin 2 and NF-κB was significantly inhibited in HGS group compared with those of ND group at p<0.05. These results suggest that glucosamine attenuates disease activity of colitis by suppressing NF-κB mediated inflammatory responses. Further efficacy studies in humans are warranted." @default.
- W2215133048 created "2016-06-24" @default.
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- W2215133048 date "2013-04-01" @default.
- W2215133048 modified "2023-10-02" @default.
- W2215133048 title "Glucosamine sulfate attenuates dextran sodium sulfate (DSS) induced colitis in mice" @default.
- W2215133048 doi "https://doi.org/10.1096/fasebj.27.1_supplement.1079.65" @default.
- W2215133048 hasPublicationYear "2013" @default.
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