FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2215492025> ?p ?o ?g. }

• W2215492025 endingPage "120" @default.
• W2215492025 startingPage "113" @default.
• W2215492025 abstract "The blood–brain barrier (BBB), comprised of brain endothelial cells with tight junctions (TJ) between them, regulates the extravasation of molecules and cells into and out of the central nervous system (CNS). Overcoming the difficulty of delivering therapeutic agents to specific regions of the brain presents a major challenge to treatment of a broad range of brain disorders. Current strategies for BBB opening are invasive, not specific, and lack precise control over the site and timing of BBB opening, which may limit their clinical translation. In the present report, we describe a novel approach based on a combination of stem cell delivery, heat-inducible gene expression and mild heating with high-intensity focused ultrasound (HIFU) under MRI guidance to remotely permeabilize BBB. The permeabilization of the BBB will be controlled with, and limited to where selected pro-inflammatory factors will be secreted secondary to HIFU activation, which is in the vicinity of the engineered stem cells and consequently both the primary and secondary disease foci. This therapeutic platform thus represents a non-invasive way for BBB opening with unprecedented spatiotemporal precision, and if properly and specifically modified, can be clinically translated to facilitate delivery of different diagnostic and therapeutic agents which can have great impact in treatment of various disease processes in the central nervous system." @default.
• W2215492025 created "2016-06-24" @default.
• W2215492025 creator A5036914466 @default.
• W2215492025 creator A5041789403 @default.
• W2215492025 creator A5045908636 @default.
• W2215492025 creator A5058049275 @default.
• W2215492025 creator A5061781981 @default.
• W2215492025 creator A5063975699 @default.
• W2215492025 creator A5089125041 @default.
• W2215492025 date "2015-11-01" @default.
• W2215492025 modified "2023-10-11" @default.
• W2215492025 title "Remote spatiotemporally controlled and biologically selective permeabilization of blood-brain barrier" @default.
• W2215492025 cites W1515496124 @default.
• W2215492025 cites W1564282316 @default.
• W2215492025 cites W1734034563 @default.
• W2215492025 cites W1942684373 @default.
• W2215492025 cites W1968955608 @default.
• W2215492025 cites W1974315180 @default.
• W2215492025 cites W1976028037 @default.
• W2215492025 cites W1978730531 @default.
• W2215492025 cites W1980441719 @default.
• W2215492025 cites W1992176533 @default.
• W2215492025 cites W1992652456 @default.
• W2215492025 cites W1996142593 @default.
• W2215492025 cites W2007113823 @default.
• W2215492025 cites W2010874271 @default.
• W2215492025 cites W2015541518 @default.
• W2215492025 cites W2017925961 @default.
• W2215492025 cites W2019759182 @default.
• W2215492025 cites W2022047142 @default.
• W2215492025 cites W2033467450 @default.
• W2215492025 cites W2034231369 @default.
• W2215492025 cites W2061294496 @default.
• W2215492025 cites W2073077090 @default.
• W2215492025 cites W2073523882 @default.
• W2215492025 cites W2075492029 @default.
• W2215492025 cites W2080694397 @default.
• W2215492025 cites W2086067422 @default.
• W2215492025 cites W2088393400 @default.
• W2215492025 cites W2094925460 @default.
• W2215492025 cites W2098459519 @default.
• W2215492025 cites W2100968876 @default.
• W2215492025 cites W2101099825 @default.
• W2215492025 cites W2108776158 @default.
• W2215492025 cites W2109460321 @default.
• W2215492025 cites W2111648798 @default.
• W2215492025 cites W2120194573 @default.
• W2215492025 cites W2126005891 @default.
• W2215492025 cites W2131739064 @default.
• W2215492025 cites W2135637759 @default.
• W2215492025 cites W2139690175 @default.
• W2215492025 cites W2146275007 @default.
• W2215492025 cites W2146830435 @default.
• W2215492025 cites W2147809951 @default.
• W2215492025 cites W2152959391 @default.
• W2215492025 cites W2153571309 @default.
• W2215492025 cites W2153805182 @default.
• W2215492025 cites W2158995414 @default.
• W2215492025 cites W2159417266 @default.
• W2215492025 cites W2159821105 @default.
• W2215492025 cites W2167405280 @default.
• W2215492025 cites W2170264215 @default.
• W2215492025 cites W2339332541 @default.
• W2215492025 cites W2419399745 @default.
• W2215492025 cites W4236697 @default.
• W2215492025 cites W62613713 @default.
• W2215492025 doi "https://doi.org/10.1016/j.jconrel.2015.08.044" @default.
• W2215492025 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4623944" @default.
• W2215492025 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26334482" @default.
• W2215492025 hasPublicationYear "2015" @default.
• W2215492025 type Work @default.
• W2215492025 sameAs 2215492025 @default.
• W2215492025 citedByCount "24" @default.
• W2215492025 countsByYear W22154920252015 @default.
• W2215492025 countsByYear W22154920252016 @default.
• W2215492025 countsByYear W22154920252017 @default.
• W2215492025 countsByYear W22154920252018 @default.
• W2215492025 countsByYear W22154920252019 @default.
• W2215492025 countsByYear W22154920252020 @default.
• W2215492025 countsByYear W22154920252021 @default.
• W2215492025 countsByYear W22154920252023 @default.
• W2215492025 crossrefType "journal-article" @default.
• W2215492025 hasAuthorship W2215492025A5036914466 @default.
• W2215492025 hasAuthorship W2215492025A5041789403 @default.
• W2215492025 hasAuthorship W2215492025A5045908636 @default.
• W2215492025 hasAuthorship W2215492025A5058049275 @default.
• W2215492025 hasAuthorship W2215492025A5061781981 @default.
• W2215492025 hasAuthorship W2215492025A5063975699 @default.
• W2215492025 hasAuthorship W2215492025A5089125041 @default.
• W2215492025 hasBestOaLocation W22154920252 @default.
• W2215492025 hasConcept C136834591 @default.
• W2215492025 hasConcept C142724271 @default.
• W2215492025 hasConcept C169760540 @default.
• W2215492025 hasConcept C177779419 @default.
• W2215492025 hasConcept C2778402981 @default.
• W2215492025 hasConcept C2779540182 @default.
• W2215492025 hasConcept C28328180 @default.
• W2215492025 hasConcept C529278444 @default.

• next