FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2215595807> ?p ?o ?g. }

• W2215595807 endingPage "e1005531" @default.
• W2215595807 startingPage "e1005531" @default.
• W2215595807 abstract "The chromosomal program of meiotic prophase, comprising events such as laying down of meiotic cohesins, synapsis between homologs, and homologous recombination, must be preceded and enabled by the regulated induction of meiotic prophase genes. This gene regulatory program is poorly understood, particularly in organisms with a segregated germline. We characterized the gene regulatory program of meiotic prophase as it occurs in the mouse fetal ovary. By profiling gene expression in the mouse fetal ovary in mutants with whole tissue and single-cell techniques, we identified 104 genes expressed specifically in pre-meiotic to pachytene germ cells. We characterized the regulation of these genes by 1) retinoic acid (RA), which induces meiosis, 2) Dazl, which is required for germ cell competence to respond to RA, and 3) Stra8, a downstream target of RA required for the chromosomal program of meiotic prophase. Initial induction of practically all identified meiotic prophase genes requires Dazl. In the presence of Dazl, RA induces at least two pathways: one Stra8-independent, and one Stra8-dependent. Genes vary in their induction by Stra8, spanning fully Stra8-independent, partially Stra8-independent, and fully Stra8-dependent. Thus, Stra8 regulates the entirety of the chromosomal program but plays a more nuanced role in governing the gene expression program. We propose that Stra8-independent gene expression enables the stockpiling of selected meiotic structural proteins prior to the commencement of the chromosomal program. Unexpectedly, we discovered that Stra8 is required for prompt down-regulation of itself and Rec8. Germ cells that have expressed and down-regulated Stra8 are refractory to further Stra8 expression. Negative feedback of Stra8, and subsequent resistance to further Stra8 expression, may ensure a single, restricted pulse of Stra8 expression. Collectively, our findings reveal a gene regulatory logic by which germ cells prepare for the chromosomal program of meiotic prophase, and ensure that it is induced only once." @default.
• W2215595807 created "2016-06-24" @default.
• W2215595807 creator A5034156995 @default.
• W2215595807 creator A5035202405 @default.
• W2215595807 creator A5053409027 @default.
• W2215595807 creator A5069145017 @default.
• W2215595807 creator A5073348028 @default.
• W2215595807 creator A5079678964 @default.
• W2215595807 date "2015-09-17" @default.
• W2215595807 modified "2023-10-06" @default.
• W2215595807 title "A Gene Regulatory Program for Meiotic Prophase in the Fetal Ovary" @default.
• W2215595807 cites W1499944371 @default.
• W2215595807 cites W1517816201 @default.
• W2215595807 cites W1575910125 @default.
• W2215595807 cites W1645470992 @default.
• W2215595807 cites W1973637933 @default.
• W2215595807 cites W1979183749 @default.
• W2215595807 cites W1987244342 @default.
• W2215595807 cites W1997444723 @default.
• W2215595807 cites W2000835221 @default.
• W2215595807 cites W2006059948 @default.
• W2215595807 cites W2007018695 @default.
• W2215595807 cites W2015962016 @default.
• W2215595807 cites W2025166348 @default.
• W2215595807 cites W2032711435 @default.
• W2215595807 cites W2036654302 @default.
• W2215595807 cites W2042969091 @default.
• W2215595807 cites W2043621728 @default.
• W2215595807 cites W2050518767 @default.
• W2215595807 cites W2054496326 @default.
• W2215595807 cites W2059702765 @default.
• W2215595807 cites W2061776278 @default.
• W2215595807 cites W2067338267 @default.
• W2215595807 cites W2070744469 @default.
• W2215595807 cites W2084598669 @default.
• W2215595807 cites W2090581673 @default.
• W2215595807 cites W2091028885 @default.
• W2215595807 cites W2096782213 @default.
• W2215595807 cites W2097065948 @default.
• W2215595807 cites W2102806129 @default.
• W2215595807 cites W2105919528 @default.
• W2215595807 cites W2111030565 @default.
• W2215595807 cites W2111902375 @default.
• W2215595807 cites W2114104545 @default.
• W2215595807 cites W2115818632 @default.
• W2215595807 cites W2120085295 @default.
• W2215595807 cites W2128965225 @default.
• W2215595807 cites W2129487614 @default.
• W2215595807 cites W2132437126 @default.
• W2215595807 cites W2134526812 @default.
• W2215595807 cites W2134710117 @default.
• W2215595807 cites W2135951244 @default.
• W2215595807 cites W2136063036 @default.
• W2215595807 cites W2141458291 @default.
• W2215595807 cites W2143526409 @default.
• W2215595807 cites W2144649761 @default.
• W2215595807 cites W2151953937 @default.
• W2215595807 cites W2153562609 @default.
• W2215595807 cites W2156326281 @default.
• W2215595807 cites W2159198265 @default.
• W2215595807 cites W2159686118 @default.
• W2215595807 cites W2162780161 @default.
• W2215595807 cites W2162811357 @default.
• W2215595807 cites W2419671199 @default.
• W2215595807 cites W4251122177 @default.
• W2215595807 cites W4256266823 @default.
• W2215595807 doi "https://doi.org/10.1371/journal.pgen.1005531" @default.
• W2215595807 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4574967" @default.
• W2215595807 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26378784" @default.
• W2215595807 hasPublicationYear "2015" @default.
• W2215595807 type Work @default.
• W2215595807 sameAs 2215595807 @default.
• W2215595807 citedByCount "83" @default.
• W2215595807 countsByYear W22155958072016 @default.
• W2215595807 countsByYear W22155958072017 @default.
• W2215595807 countsByYear W22155958072018 @default.
• W2215595807 countsByYear W22155958072019 @default.
• W2215595807 countsByYear W22155958072020 @default.
• W2215595807 countsByYear W22155958072021 @default.
• W2215595807 countsByYear W22155958072022 @default.
• W2215595807 countsByYear W22155958072023 @default.
• W2215595807 crossrefType "journal-article" @default.
• W2215595807 hasAuthorship W2215595807A5034156995 @default.
• W2215595807 hasAuthorship W2215595807A5035202405 @default.
• W2215595807 hasAuthorship W2215595807A5053409027 @default.
• W2215595807 hasAuthorship W2215595807A5069145017 @default.
• W2215595807 hasAuthorship W2215595807A5073348028 @default.
• W2215595807 hasAuthorship W2215595807A5079678964 @default.
• W2215595807 hasBestOaLocation W22155958071 @default.
• W2215595807 hasConcept C104317684 @default.
• W2215595807 hasConcept C148196450 @default.
• W2215595807 hasConcept C201437064 @default.
• W2215595807 hasConcept C2779122487 @default.
• W2215595807 hasConcept C45413362 @default.
• W2215595807 hasConcept C54355233 @default.
• W2215595807 hasConcept C64894306 @default.
• W2215595807 hasConcept C86803240 @default.
• W2215595807 hasConcept C95444343 @default.

• next