FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2215658470> ?p ?o ?g. }

• W2215658470 endingPage "9" @default.
• W2215658470 startingPage "502" @default.
• W2215658470 abstract "To investigate the role and molecular mechanism of membrane-associated guanylate kinase inverted 3 (MAGI3) in glioma cell proliferation.The expression levels of MAGI3 and PTEN were assessed in glioma samples by Western blotting. MAGI3 was stably transfected into C6 glioma cells to obtain C6-MAGI3 cells. Then, the proliferation, the expression levels of MAGI3 and PTEN, and Akt phosphorylation were evaluated in C6 and C6-MAGI3 cells. Xenograft tumor models were established by subcutaneous injection of C6 and C6-MAGI3 cells into nude mice, and the growth rates of xenografts in the mice were compared. The potential role of MAGI3 expression in PI3K/Akt signaling activation was further investigated by examining the correlation between MAGI3 expression and the expression of PI3K/Akt signaling downstream target genes in a glioma dataset using gene set enrichment analysis (GSEA).Expression levels of MAGI3 and PTEN were significantly downregulated in gliomas. Overexpression of MAGI3 in the glioma C6 cell line upregulated PTEN protein expression, inhibited the phosphorylation of Akt, and suppressed cell proliferation. MAGI3 overexpression also inhibited the growth of C6 glioma tumor xenografts in nude mice. Analysis based on the GEO database confirmed the negative correlation between activation of PI3K/Akt pathway and MAGI3 mRNA levels in human glioma samples.The loss of MAGI3 expression in glioma may enhance the proliferation of glioma cells via downregulation of PTEN expression, leading to the activation of the PI3K/Akt pathway. MAGI3 is a potential glioma suppressor." @default.
• W2215658470 created "2016-06-24" @default.
• W2215658470 creator A5017931611 @default.
• W2215658470 creator A5018543541 @default.
• W2215658470 creator A5022284407 @default.
• W2215658470 creator A5038450472 @default.
• W2215658470 creator A5045283142 @default.
• W2215658470 creator A5050670539 @default.
• W2215658470 creator A5052342599 @default.
• W2215658470 creator A5055667105 @default.
• W2215658470 creator A5065410562 @default.
• W2215658470 creator A5086664284 @default.
• W2215658470 creator A5087236737 @default.
• W2215658470 date "2015-07-01" @default.
• W2215658470 modified "2023-10-18" @default.
• W2215658470 title "MAGI3 Suppresses Glioma Cell Proliferation via Upregulation of PTEN Expression." @default.
• W2215658470 cites W1673025041 @default.
• W2215658470 cites W1855056902 @default.
• W2215658470 cites W1983268824 @default.
• W2215658470 cites W1984515231 @default.
• W2215658470 cites W2000193607 @default.
• W2215658470 cites W2010677999 @default.
• W2215658470 cites W2012083949 @default.
• W2215658470 cites W2017739035 @default.
• W2215658470 cites W2019017173 @default.
• W2215658470 cites W2024220711 @default.
• W2215658470 cites W2028119906 @default.
• W2215658470 cites W2030866834 @default.
• W2215658470 cites W2035437790 @default.
• W2215658470 cites W2050039768 @default.
• W2215658470 cites W2068915942 @default.
• W2215658470 cites W2085826323 @default.
• W2215658470 cites W2087724775 @default.
• W2215658470 cites W2088138181 @default.
• W2215658470 cites W2112785522 @default.
• W2215658470 cites W2115862526 @default.
• W2215658470 cites W2122522737 @default.
• W2215658470 cites W2125096000 @default.
• W2215658470 cites W2130410032 @default.
• W2215658470 cites W2134807618 @default.
• W2215658470 cites W2151134851 @default.
• W2215658470 cites W2170379027 @default.
• W2215658470 cites W2145801480 @default.
• W2215658470 cites W51649994 @default.
• W2215658470 doi "https://doi.org/10.3967/bes2015.072" @default.
• W2215658470 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26248734" @default.
• W2215658470 hasPublicationYear "2015" @default.
• W2215658470 type Work @default.
• W2215658470 sameAs 2215658470 @default.
• W2215658470 citedByCount "13" @default.
• W2215658470 countsByYear W22156584702016 @default.
• W2215658470 countsByYear W22156584702017 @default.
• W2215658470 countsByYear W22156584702018 @default.
• W2215658470 countsByYear W22156584702020 @default.
• W2215658470 countsByYear W22156584702021 @default.
• W2215658470 countsByYear W22156584702022 @default.
• W2215658470 crossrefType "journal-article" @default.
• W2215658470 hasAuthorship W2215658470A5017931611 @default.
• W2215658470 hasAuthorship W2215658470A5018543541 @default.
• W2215658470 hasAuthorship W2215658470A5022284407 @default.
• W2215658470 hasAuthorship W2215658470A5038450472 @default.
• W2215658470 hasAuthorship W2215658470A5045283142 @default.
• W2215658470 hasAuthorship W2215658470A5050670539 @default.
• W2215658470 hasAuthorship W2215658470A5052342599 @default.
• W2215658470 hasAuthorship W2215658470A5055667105 @default.
• W2215658470 hasAuthorship W2215658470A5065410562 @default.
• W2215658470 hasAuthorship W2215658470A5086664284 @default.
• W2215658470 hasAuthorship W2215658470A5087236737 @default.
• W2215658470 hasConcept C104317684 @default.
• W2215658470 hasConcept C127561419 @default.
• W2215658470 hasConcept C185592680 @default.
• W2215658470 hasConcept C2777609662 @default.
• W2215658470 hasConcept C2778227246 @default.
• W2215658470 hasConcept C502942594 @default.
• W2215658470 hasConcept C54009773 @default.
• W2215658470 hasConcept C54355233 @default.
• W2215658470 hasConcept C55493867 @default.
• W2215658470 hasConcept C62112901 @default.
• W2215658470 hasConcept C62478195 @default.
• W2215658470 hasConcept C75217442 @default.
• W2215658470 hasConcept C81885089 @default.
• W2215658470 hasConcept C86554907 @default.
• W2215658470 hasConcept C86803240 @default.
• W2215658470 hasConcept C95444343 @default.
• W2215658470 hasConceptScore W2215658470C104317684 @default.
• W2215658470 hasConceptScore W2215658470C127561419 @default.
• W2215658470 hasConceptScore W2215658470C185592680 @default.
• W2215658470 hasConceptScore W2215658470C2777609662 @default.
• W2215658470 hasConceptScore W2215658470C2778227246 @default.
• W2215658470 hasConceptScore W2215658470C502942594 @default.
• W2215658470 hasConceptScore W2215658470C54009773 @default.
• W2215658470 hasConceptScore W2215658470C54355233 @default.
• W2215658470 hasConceptScore W2215658470C55493867 @default.
• W2215658470 hasConceptScore W2215658470C62112901 @default.
• W2215658470 hasConceptScore W2215658470C62478195 @default.
• W2215658470 hasConceptScore W2215658470C75217442 @default.
• W2215658470 hasConceptScore W2215658470C81885089 @default.
• W2215658470 hasConceptScore W2215658470C86554907 @default.

• next