Matches in SemOpenAlex for { <https://semopenalex.org/work/W2215672988> ?p ?o ?g. }
- W2215672988 abstract "We have shown that serotonin transporter (SERT) clustering in blood lymphocytes is altered in major depression and correlates with pharmacological therapeutic responses measured with the Hamilton scale. In the present report, we extend these results to the self-assessment anhedonia scale, as anhedonia is a cardinal symptom of major depression that is difficult to treat with first-line antidepressants.We collected blood samples from 38 untreated depression patients at the time of enrolment and 8 weeks after pharmacological treatment. We used the self-assessment anhedonia scale to evaluate anhedonia symptoms before and after treatment. We also used quantitative immunocytochemistry to measure SERT clusters in blood lymphocytes.Evaluation of the distribution of SERT clusters size in the plasma membrane of lymphocytes identified two subpopulations of naive depression patients: Depression I (D-I) and Depression II (D-II). While naïve D-I and D-II patients initially showed similar anhedonia scores, D-II patients showed a good response in anhedonia symptoms after 8 weeks of psychopharmacological treatment, whereas D-I patients failed to show any improvement. Psychopharmacological treatment also induced an increase in the number of SERT clusters in lymphocytes in the D-II group, and this increase correlated with the improvement in anhedonia symptoms.SERT clustering in peripheral lymphocytes can be used to identify patient response to antidepressant therapy as ascertained by anhedonia scores." @default.
- W2215672988 created "2016-06-24" @default.
- W2215672988 creator A5003005692 @default.
- W2215672988 creator A5026946413 @default.
- W2215672988 creator A5031563324 @default.
- W2215672988 creator A5050160250 @default.
- W2215672988 creator A5066330738 @default.
- W2215672988 creator A5091474693 @default.
- W2215672988 date "2015-12-01" @default.
- W2215672988 modified "2023-10-05" @default.
- W2215672988 title "Serotonin transporter clustering in blood lymphocytes predicts the outcome on anhedonia scores in naïve depressive patients treated with antidepressant medication" @default.
- W2215672988 cites W104772228 @default.
- W2215672988 cites W1537840408 @default.
- W2215672988 cites W1978517473 @default.
- W2215672988 cites W1994036059 @default.
- W2215672988 cites W2000694352 @default.
- W2215672988 cites W2024447131 @default.
- W2215672988 cites W2028046530 @default.
- W2215672988 cites W2032542268 @default.
- W2215672988 cites W2035572502 @default.
- W2215672988 cites W2056175300 @default.
- W2215672988 cites W2057949614 @default.
- W2215672988 cites W2077263385 @default.
- W2215672988 cites W2081771212 @default.
- W2215672988 cites W2083480536 @default.
- W2215672988 cites W2084674758 @default.
- W2215672988 cites W2085247371 @default.
- W2215672988 cites W2086695564 @default.
- W2215672988 cites W2093073145 @default.
- W2215672988 cites W2101540672 @default.
- W2215672988 cites W2106916957 @default.
- W2215672988 cites W2108442570 @default.
- W2215672988 cites W2113181865 @default.
- W2215672988 cites W2114613490 @default.
- W2215672988 cites W2115714588 @default.
- W2215672988 cites W2120362779 @default.
- W2215672988 cites W2129579709 @default.
- W2215672988 cites W2131991903 @default.
- W2215672988 cites W2132324173 @default.
- W2215672988 cites W2149154629 @default.
- W2215672988 cites W2165226337 @default.
- W2215672988 cites W2169442707 @default.
- W2215672988 cites W4229631364 @default.
- W2215672988 cites W4247665917 @default.
- W2215672988 doi "https://doi.org/10.1186/s12991-015-0085-8" @default.
- W2215672988 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4687131" @default.
- W2215672988 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26697099" @default.
- W2215672988 hasPublicationYear "2015" @default.
- W2215672988 type Work @default.
- W2215672988 sameAs 2215672988 @default.
- W2215672988 citedByCount "13" @default.
- W2215672988 countsByYear W22156729882016 @default.
- W2215672988 countsByYear W22156729882017 @default.
- W2215672988 countsByYear W22156729882018 @default.
- W2215672988 countsByYear W22156729882019 @default.
- W2215672988 countsByYear W22156729882020 @default.
- W2215672988 countsByYear W22156729882021 @default.
- W2215672988 countsByYear W22156729882022 @default.
- W2215672988 countsByYear W22156729882023 @default.
- W2215672988 crossrefType "journal-article" @default.
- W2215672988 hasAuthorship W2215672988A5003005692 @default.
- W2215672988 hasAuthorship W2215672988A5026946413 @default.
- W2215672988 hasAuthorship W2215672988A5031563324 @default.
- W2215672988 hasAuthorship W2215672988A5050160250 @default.
- W2215672988 hasAuthorship W2215672988A5066330738 @default.
- W2215672988 hasAuthorship W2215672988A5091474693 @default.
- W2215672988 hasBestOaLocation W22156729881 @default.
- W2215672988 hasConcept C118552586 @default.
- W2215672988 hasConcept C126322002 @default.
- W2215672988 hasConcept C134018914 @default.
- W2215672988 hasConcept C139719470 @default.
- W2215672988 hasConcept C15744967 @default.
- W2215672988 hasConcept C162324750 @default.
- W2215672988 hasConcept C170493617 @default.
- W2215672988 hasConcept C2775864247 @default.
- W2215672988 hasConcept C2776412080 @default.
- W2215672988 hasConcept C2776867660 @default.
- W2215672988 hasConcept C2778897192 @default.
- W2215672988 hasConcept C2778941446 @default.
- W2215672988 hasConcept C2779177272 @default.
- W2215672988 hasConcept C2780051608 @default.
- W2215672988 hasConcept C2780733359 @default.
- W2215672988 hasConcept C2781161787 @default.
- W2215672988 hasConcept C70410870 @default.
- W2215672988 hasConcept C71924100 @default.
- W2215672988 hasConceptScore W2215672988C118552586 @default.
- W2215672988 hasConceptScore W2215672988C126322002 @default.
- W2215672988 hasConceptScore W2215672988C134018914 @default.
- W2215672988 hasConceptScore W2215672988C139719470 @default.
- W2215672988 hasConceptScore W2215672988C15744967 @default.
- W2215672988 hasConceptScore W2215672988C162324750 @default.
- W2215672988 hasConceptScore W2215672988C170493617 @default.
- W2215672988 hasConceptScore W2215672988C2775864247 @default.
- W2215672988 hasConceptScore W2215672988C2776412080 @default.
- W2215672988 hasConceptScore W2215672988C2776867660 @default.
- W2215672988 hasConceptScore W2215672988C2778897192 @default.
- W2215672988 hasConceptScore W2215672988C2778941446 @default.
- W2215672988 hasConceptScore W2215672988C2779177272 @default.
- W2215672988 hasConceptScore W2215672988C2780051608 @default.
- W2215672988 hasConceptScore W2215672988C2780733359 @default.