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- W2215692415 abstract "3633 Background: Capecitabine is an oral fluoropyrimidine commonly used in a cycling 21 day schedule with 14 days on and 7 days off with a daily dose of 2000 to 2500 mg/m2. The major limiting toxicities with this dose and schedule are diarrhea and hand/foot syndrome. A daily “fixed dose” not based on m2 and with a continuous uninterrupted non cycling schedule offers the potential for continuous exposure emulating the parenteral low dose protracted 5-fluorouracil infusion and the potential for less toxicity. Methods: Fifty consecutive patients receiving fixed dose (2000 mg/day) continuous (non cycling) dosing of capecitabine were retrospectively reviewed to determine feasibility, patterns of toxicity and tolerability of this dose schedule. Diagnosis included colon cancer, 26 patients; other GI cancers, 6 patients; GU tumors, 8 patients; and breast cancer, 7 patients. Nineteen of 50 patients received the fixed daily capecitabine dosing as a single agent and 31 patients received capecitabine as part of a mul..." @default.
- W2215692415 created "2016-06-24" @default.
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- W2215692415 date "2004-07-15" @default.
- W2215692415 modified "2023-09-27" @default.
- W2215692415 title "Continuous fixed dose schedule for capecitabine" @default.
- W2215692415 doi "https://doi.org/10.1200/jco.2004.22.14_suppl.3633" @default.
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