Matches in SemOpenAlex for { <https://semopenalex.org/work/W2215707722> ?p ?o ?g. }
- W2215707722 endingPage "305" @default.
- W2215707722 startingPage "282" @default.
- W2215707722 abstract "Lymphocytes sense and then respond to their environment utilizing a collection of membrane receptors. Arguably, the most important of these are the clonotypic antigen receptors, membrane immunoglobulin (mIg) on B cells, and T-cell receptor (TCR) on T cells. These receptors uniquely recognize specific foreign and self-antigens. In order to provide protection against pathogens, the receptor–antigen interactions in mature lymphocytes generally culminate in clonal expansion and/or differentiation into effector cells (reviewed in Nemazee et al., 1991; Nossal, 1992; van Oers, 1999). On the other hand, so as to diminish the likelihood of autoimmune disease, ligation of these receptors with self-antigen in immature lymphocytes initiates a series of events leading to anergy, receptor editing, or death. While the detailed mechanisms of signal transduction in T and B cells are distinct, in many respects, the TCR and the B-cell receptor (BCR) utilize similar mechanisms (Scheuermann and Uhr, 1995, van Oers, 1999). In particular, although neither the TCR nor the mIg possess intrinsic protein tyrosine kinase (PTK) activity, receptor-mediated protein tyrosine phosphorylation is upregulated immediately following antigen binding. Similar tyrosine kinase-dependent phosphorylation events are central to both B- and T-cell signal transduction cascades (Chan et al., 1994; Gold et al., 1990, 1991). Additionally, Ca2 + transients are evident in both cell types soon after receptor engagement of antigen so that in addition to phosphotyrosine-based signaling, signal transduction is also heavily dependent on Ca2 + as a second messenger." @default.
- W2215707722 created "2016-06-24" @default.
- W2215707722 creator A5049983845 @default.
- W2215707722 creator A5076924157 @default.
- W2215707722 date "2018-01-01" @default.
- W2215707722 modified "2023-09-27" @default.
- W2215707722 title "Antigen-Specific Signal Transduction" @default.
- W2215707722 cites W1418681102 @default.
- W2215707722 cites W1481419339 @default.
- W2215707722 cites W1482593432 @default.
- W2215707722 cites W1484685014 @default.
- W2215707722 cites W1487018400 @default.
- W2215707722 cites W1488229599 @default.
- W2215707722 cites W1509881480 @default.
- W2215707722 cites W1519658334 @default.
- W2215707722 cites W1522219769 @default.
- W2215707722 cites W1538902372 @default.
- W2215707722 cites W1551296854 @default.
- W2215707722 cites W1562441478 @default.
- W2215707722 cites W1566606277 @default.
- W2215707722 cites W1569503463 @default.
- W2215707722 cites W1574211886 @default.
- W2215707722 cites W1574251785 @default.
- W2215707722 cites W1575248396 @default.
- W2215707722 cites W1583957430 @default.
- W2215707722 cites W1595867504 @default.
- W2215707722 cites W1604831151 @default.
- W2215707722 cites W1608689696 @default.
- W2215707722 cites W1616490052 @default.
- W2215707722 cites W1635630008 @default.
- W2215707722 cites W164293537 @default.
- W2215707722 cites W1750024901 @default.
- W2215707722 cites W1785108662 @default.
- W2215707722 cites W1804861156 @default.
- W2215707722 cites W1806946083 @default.
- W2215707722 cites W1885397918 @default.
- W2215707722 cites W1893679786 @default.
- W2215707722 cites W1901641191 @default.
- W2215707722 cites W1947991388 @default.
- W2215707722 cites W1965678722 @default.
- W2215707722 cites W1966851529 @default.
- W2215707722 cites W1967234833 @default.
- W2215707722 cites W1967835314 @default.
- W2215707722 cites W1968760758 @default.
- W2215707722 cites W1969000493 @default.
- W2215707722 cites W1970180329 @default.
- W2215707722 cites W1970486693 @default.
- W2215707722 cites W1971240700 @default.
- W2215707722 cites W1971692004 @default.
- W2215707722 cites W1972151345 @default.
- W2215707722 cites W1973803951 @default.
- W2215707722 cites W1978359047 @default.
- W2215707722 cites W1979012323 @default.
- W2215707722 cites W1979644837 @default.
- W2215707722 cites W1979769420 @default.
- W2215707722 cites W1983612298 @default.
- W2215707722 cites W1983960385 @default.
- W2215707722 cites W1987146610 @default.
- W2215707722 cites W1989342624 @default.
- W2215707722 cites W1989535960 @default.
- W2215707722 cites W1989578216 @default.
- W2215707722 cites W1991210089 @default.
- W2215707722 cites W1992877333 @default.
- W2215707722 cites W1995110654 @default.
- W2215707722 cites W1995181168 @default.
- W2215707722 cites W1995835059 @default.
- W2215707722 cites W1999931163 @default.
- W2215707722 cites W2001324898 @default.
- W2215707722 cites W2003216771 @default.
- W2215707722 cites W2006413140 @default.
- W2215707722 cites W2006519779 @default.
- W2215707722 cites W2006605446 @default.
- W2215707722 cites W2007305532 @default.
- W2215707722 cites W2008295169 @default.
- W2215707722 cites W2008636329 @default.
- W2215707722 cites W2009818164 @default.
- W2215707722 cites W2010736123 @default.
- W2215707722 cites W2011593699 @default.
- W2215707722 cites W2013611981 @default.
- W2215707722 cites W2014326164 @default.
- W2215707722 cites W2014395237 @default.
- W2215707722 cites W2014574326 @default.
- W2215707722 cites W2015001083 @default.
- W2215707722 cites W2015012549 @default.
- W2215707722 cites W2015066743 @default.
- W2215707722 cites W2015319133 @default.
- W2215707722 cites W2016134576 @default.
- W2215707722 cites W2017507133 @default.
- W2215707722 cites W2018344755 @default.
- W2215707722 cites W2019904725 @default.
- W2215707722 cites W2021132659 @default.
- W2215707722 cites W2022116029 @default.
- W2215707722 cites W2022446231 @default.
- W2215707722 cites W2024952102 @default.
- W2215707722 cites W2025081899 @default.
- W2215707722 cites W2027039293 @default.
- W2215707722 cites W2027731275 @default.
- W2215707722 cites W2028076004 @default.