FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2215746560> ?p ?o ?g. }

• W2215746560 endingPage "702" @default.
• W2215746560 startingPage "691" @default.
• W2215746560 abstract "Mycobacterium tuberculosis cell wall glycolipid, lipoarabinomannan, can inhibit CD4(+) T cell activation by downregulating the phosphorylation of key proximal TCR signaling molecules: Lck, CD3ζ, ZAP70, and LAT. Inhibition of proximal TCR signaling can result in T cell anergy, in which T cells are inactivated following an Ag encounter, yet remain viable and hyporesponsive. We tested whether mannose-capped lipoarabinomannan (LAM)-induced inhibition of CD4(+) T cell activation resulted in CD4(+) T cell anergy. The presence of LAM during primary stimulation of P25 TCR-transgenic murine CD4(+) T cells with M. tuberculosis Ag85B peptide resulted in decreased proliferation and IL-2 production. P25 TCR-transgenic CD4(+) T cells primed in the presence of LAM also exhibited decreased response upon restimulation with Ag85B. The T cell anergic state persisted after the removal of LAM. Hyporesponsiveness to restimulation was not due to apoptosis, generation of Foxp3-positive regulatory T cells, or inhibitory cytokines. Acquisition of the anergic phenotype correlated with upregulation of gene related to anergy in lymphocytes (GRAIL) protein in CD4(+) T cells. Inhibition of human CD4(+) T cell activation by LAM also was associated with increased GRAIL expression. Small interfering RNA-mediated knockdown of GRAIL before LAM treatment abrogated LAM-induced hyporesponsiveness. In addition, exogenous IL-2 reversed defective proliferation by downregulating GRAIL expression. These results demonstrate that LAM upregulates GRAIL to induce anergy in Ag-reactive CD4(+) T cells. Induction of CD4(+) T cell anergy by LAM may represent one mechanism by which M. tuberculosis evades T cell recognition." @default.
• W2215746560 created "2016-06-24" @default.
• W2215746560 creator A5006934532 @default.
• W2215746560 creator A5015358679 @default.
• W2215746560 creator A5053780153 @default.
• W2215746560 creator A5055729386 @default.
• W2215746560 creator A5067630978 @default.
• W2215746560 creator A5086951518 @default.
• W2215746560 creator A5089408791 @default.
• W2215746560 date "2016-01-15" @default.
• W2215746560 modified "2023-10-05" @default.
• W2215746560 title "Mannose-Capped Lipoarabinomannan from <i>Mycobacterium tuberculosis</i> Induces CD4+ T Cell Anergy via GRAIL" @default.
• W2215746560 cites W1489360290 @default.
• W2215746560 cites W1490175179 @default.
• W2215746560 cites W1497531634 @default.
• W2215746560 cites W1506816348 @default.
• W2215746560 cites W1588790881 @default.
• W2215746560 cites W1597345474 @default.
• W2215746560 cites W1621676818 @default.
• W2215746560 cites W1769107479 @default.
• W2215746560 cites W1865580510 @default.
• W2215746560 cites W1870658879 @default.
• W2215746560 cites W1919175305 @default.
• W2215746560 cites W1960395549 @default.
• W2215746560 cites W1966621240 @default.
• W2215746560 cites W1986246471 @default.
• W2215746560 cites W1996649087 @default.
• W2215746560 cites W2005028020 @default.
• W2215746560 cites W2011302363 @default.
• W2215746560 cites W2026326779 @default.
• W2215746560 cites W2027189611 @default.
• W2215746560 cites W2030269101 @default.
• W2215746560 cites W2038600671 @default.
• W2215746560 cites W2038631586 @default.
• W2215746560 cites W2046459432 @default.
• W2215746560 cites W2055472767 @default.
• W2215746560 cites W2063060777 @default.
• W2215746560 cites W2066321034 @default.
• W2215746560 cites W2079722764 @default.
• W2215746560 cites W2080935287 @default.
• W2215746560 cites W2082734149 @default.
• W2215746560 cites W2087724831 @default.
• W2215746560 cites W2090558644 @default.
• W2215746560 cites W2091367076 @default.
• W2215746560 cites W2099092516 @default.
• W2215746560 cites W2105219899 @default.
• W2215746560 cites W2108959011 @default.
• W2215746560 cites W2109860765 @default.
• W2215746560 cites W2111945182 @default.
• W2215746560 cites W2112506009 @default.
• W2215746560 cites W2113190700 @default.
• W2215746560 cites W2115240926 @default.
• W2215746560 cites W2117269874 @default.
• W2215746560 cites W2124828758 @default.
• W2215746560 cites W2126245681 @default.
• W2215746560 cites W2127491513 @default.
• W2215746560 cites W2130506153 @default.
• W2215746560 cites W2131443741 @default.
• W2215746560 cites W2139559598 @default.
• W2215746560 cites W2143488564 @default.
• W2215746560 cites W2145640458 @default.
• W2215746560 cites W2146839864 @default.
• W2215746560 cites W2150904674 @default.
• W2215746560 cites W2155384604 @default.
• W2215746560 cites W2155464214 @default.
• W2215746560 cites W2163030178 @default.
• W2215746560 cites W2172223853 @default.
• W2215746560 doi "https://doi.org/10.4049/jimmunol.1500710" @default.
• W2215746560 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4707121" @default.
• W2215746560 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26667170" @default.
• W2215746560 hasPublicationYear "2016" @default.
• W2215746560 type Work @default.
• W2215746560 sameAs 2215746560 @default.
• W2215746560 citedByCount "32" @default.
• W2215746560 countsByYear W22157465602016 @default.
• W2215746560 countsByYear W22157465602017 @default.
• W2215746560 countsByYear W22157465602018 @default.
• W2215746560 countsByYear W22157465602019 @default.
• W2215746560 countsByYear W22157465602020 @default.
• W2215746560 countsByYear W22157465602021 @default.
• W2215746560 countsByYear W22157465602022 @default.
• W2215746560 countsByYear W22157465602023 @default.
• W2215746560 crossrefType "journal-article" @default.
• W2215746560 hasAuthorship W2215746560A5006934532 @default.
• W2215746560 hasAuthorship W2215746560A5015358679 @default.
• W2215746560 hasAuthorship W2215746560A5053780153 @default.
• W2215746560 hasAuthorship W2215746560A5055729386 @default.
• W2215746560 hasAuthorship W2215746560A5067630978 @default.
• W2215746560 hasAuthorship W2215746560A5086951518 @default.
• W2215746560 hasAuthorship W2215746560A5089408791 @default.
• W2215746560 hasBestOaLocation W22157465601 @default.
• W2215746560 hasConcept C142724271 @default.
• W2215746560 hasConcept C148125776 @default.
• W2215746560 hasConcept C153911025 @default.
• W2215746560 hasConcept C19317047 @default.
• W2215746560 hasConcept C203014093 @default.
• W2215746560 hasConcept C2776056871 @default.
• W2215746560 hasConcept C2776090121 @default.

• next