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• W2215800660 abstract "Two new series of EP4 antagonists containing a 3-methylaryl-2-carbonyl core have been identified. One series has a 3-substituted-phenyl core, while the other one incorporates a 3-substituted pyridine. Both series led to compounds with potent activity in functional and human whole blood (hWB) assays. In the pyridine series, compound 7a was found to be a highly potent and selective EP4 antagonist, with suitable rat and dog pharmacokinetic profiles." @default.
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• W2215800660 date "2016-02-01" @default.
• W2215800660 modified "2023-10-17" @default.
• W2215800660 title "Discovery of potent aryl-substituted 3-[(3-methylpyridine-2-carbonyl) amino]-2,4-dimethyl-benzoic acid EP4 antagonists with improved pharmacokinetic profile" @default.
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• W2215800660 doi "https://doi.org/10.1016/j.bmcl.2015.12.057" @default.
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