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- W2215812048 abstract "The basic hypothesis that specific antiretroviral agents should ameliorate the course of HIV infection is now supported, by clinical trials, with nucleoside-based inhibitors of the viral reverse transcriptase. Unfortunately, the most widely used of these agents—azidothymidine (AZT) and dideoxyinosine (DDI)—can have significant toxicity and the mutations in the viral target can lead to drug resistance. While nonnucleoside inhibitors of the reverse transcriptase may overcome some of these problems, inhibitors of other essential viral proteins should also be useful, either as single agents or in combination. Just a few years after the sequence of the HIV genome became available, inhibitors of such a protein, the HIV protease, were close to being used in the experimental AIDS therapy. Several factors contributed to this rapid progress. Sequence homologies of HIV-1, with previously studied retroviruses, supported the existence of the protease enzyme and the presence of a conserved Asp–Thr–Gly sequence advocated membership in the aspartyl protease class. This classification, coupled with homology-based predictions of substrate sequences, meant that the strategies developed for the design of inhibitors of renin, an aspartic proteinase, involved in the regulation of blood pressure, would be directly applicable to the HIV protease. This chapter discusses viral protease, the HIV-1 protease, role of the HIV protease, the viral life cycle, in vitro assays for protease inhibition, substrate specificities, design of protease inhibitors, antiviral activities of protease inhibitors, and their future prospects. The chapter also discusses the subsite specificity in the substrates of HIV protease and peptide-based inhibitors of the HIV protease." @default.
- W2215812048 created "2016-06-24" @default.
- W2215812048 creator A5018188145 @default.
- W2215812048 creator A5041336354 @default.
- W2215812048 date "1991-01-01" @default.
- W2215812048 modified "2023-09-26" @default.
- W2215812048 title "Chapter 15. HIV Protease Inhibitors" @default.
- W2215812048 cites W1219801572 @default.
- W2215812048 cites W1481024063 @default.
- W2215812048 cites W1496279789 @default.
- W2215812048 cites W1499808375 @default.
- W2215812048 cites W1529867353 @default.
- W2215812048 cites W1555843425 @default.
- W2215812048 cites W1563729281 @default.
- W2215812048 cites W1574841922 @default.
- W2215812048 cites W1637218542 @default.
- W2215812048 cites W172431925 @default.
- W2215812048 cites W1892408656 @default.
- W2215812048 cites W1963675638 @default.
- W2215812048 cites W1964204654 @default.
- W2215812048 cites W1965349185 @default.
- W2215812048 cites W1966952510 @default.
- W2215812048 cites W1974224443 @default.
- W2215812048 cites W1977790220 @default.
- W2215812048 cites W1980259340 @default.
- W2215812048 cites W1981555301 @default.
- W2215812048 cites W1981730696 @default.
- W2215812048 cites W1984276811 @default.
- W2215812048 cites W1986348937 @default.
- W2215812048 cites W1986671430 @default.
- W2215812048 cites W1987263968 @default.
- W2215812048 cites W1987688509 @default.
- W2215812048 cites W1989475707 @default.
- W2215812048 cites W1992651835 @default.
- W2215812048 cites W1995396220 @default.
- W2215812048 cites W1998188333 @default.
- W2215812048 cites W2006327082 @default.
- W2215812048 cites W2007717937 @default.
- W2215812048 cites W2007989611 @default.
- W2215812048 cites W2010546503 @default.
- W2215812048 cites W2012729050 @default.
- W2215812048 cites W2014237494 @default.
- W2215812048 cites W2015442084 @default.
- W2215812048 cites W2021890624 @default.
- W2215812048 cites W2022973223 @default.
- W2215812048 cites W2023241074 @default.
- W2215812048 cites W2024131050 @default.
- W2215812048 cites W2026066319 @default.
- W2215812048 cites W2028156315 @default.
- W2215812048 cites W2030017358 @default.
- W2215812048 cites W2036670543 @default.
- W2215812048 cites W2037695285 @default.
- W2215812048 cites W2038350697 @default.
- W2215812048 cites W2040938282 @default.
- W2215812048 cites W2041299378 @default.
- W2215812048 cites W2044659031 @default.
- W2215812048 cites W2047816735 @default.
- W2215812048 cites W2053702224 @default.
- W2215812048 cites W2056704605 @default.
- W2215812048 cites W2057501205 @default.
- W2215812048 cites W2060952336 @default.
- W2215812048 cites W2064978957 @default.
- W2215812048 cites W2067109667 @default.
- W2215812048 cites W2069366448 @default.
- W2215812048 cites W2070368233 @default.
- W2215812048 cites W2070542558 @default.
- W2215812048 cites W2072409481 @default.
- W2215812048 cites W2072822306 @default.
- W2215812048 cites W2073302617 @default.
- W2215812048 cites W2080786231 @default.
- W2215812048 cites W2085318243 @default.
- W2215812048 cites W2085513539 @default.
- W2215812048 cites W2087876594 @default.
- W2215812048 cites W2092093169 @default.
- W2215812048 cites W2092790774 @default.
- W2215812048 cites W2093561963 @default.
- W2215812048 cites W2108612435 @default.
- W2215812048 cites W2114435740 @default.
- W2215812048 cites W2114742412 @default.
- W2215812048 cites W2115869555 @default.
- W2215812048 cites W2117149353 @default.
- W2215812048 cites W2118442883 @default.
- W2215812048 cites W2135785813 @default.
- W2215812048 cites W2139235397 @default.
- W2215812048 cites W2160276605 @default.
- W2215812048 cites W2165732545 @default.
- W2215812048 cites W2169655668 @default.
- W2215812048 cites W2470200999 @default.
- W2215812048 cites W2487812703 @default.
- W2215812048 cites W4211162080 @default.
- W2215812048 cites W4211174380 @default.
- W2215812048 cites W4231484789 @default.
- W2215812048 doi "https://doi.org/10.1016/s0065-7743(08)61202-6" @default.
- W2215812048 hasPublicationYear "1991" @default.
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