Matches in SemOpenAlex for { <https://semopenalex.org/work/W2215900300> ?p ?o ?g. }
- W2215900300 endingPage "168" @default.
- W2215900300 startingPage "161" @default.
- W2215900300 abstract "Newly designed microcapsules (MC) combining a core of solid lipid nanoparticle (SLN) and a mesoporous silica shell have been developed and explored as oral delivery system of curcumin (CU). CU-loaded MC (MC-CU) are 2 μm sized and have a mesoporous silica shell of 0.3 μm thickness with a wormlike structure as characterized by small angle X-ray scattering (SAXS), nitrogen adsorption/desorption and transmission electron microscopy (TEM) measurements. It was found that SLN acts as reservoir of curcumin while the mesoporous shell insures the protection and the controlled release of the drug. MC-CU displayed a pH-dependent in vitro release profile with marked drug retention at pH 2.8. Neutral red uptake assay together with confocal laser scanning microscopy (CLSM) showed a good cell tolerance to MC-CU at relatively high concentration of inert materials. Besides, the cell-uptake test revealed that fluorescent-MC were well internalized into Caco-2 cells, confirming the possibility to use MC for gut cells targeting. These findings suggest that organic core-silica shell microcapsules are promising drug delivery systems with enhanced bioavailability for poorly soluble drugs." @default.
- W2215900300 created "2016-06-24" @default.
- W2215900300 creator A5048431419 @default.
- W2215900300 creator A5051609522 @default.
- W2215900300 creator A5058838850 @default.
- W2215900300 creator A5065916745 @default.
- W2215900300 creator A5087148837 @default.
- W2215900300 date "2016-04-01" @default.
- W2215900300 modified "2023-10-09" @default.
- W2215900300 title "Core–shell microcapsules of solid lipid nanoparticles and mesoporous silica for enhanced oral delivery of curcumin" @default.
- W2215900300 cites W1248683074 @default.
- W2215900300 cites W1664719478 @default.
- W2215900300 cites W1774764329 @default.
- W2215900300 cites W1969029180 @default.
- W2215900300 cites W1970221369 @default.
- W2215900300 cites W1970672844 @default.
- W2215900300 cites W1976194786 @default.
- W2215900300 cites W1976597949 @default.
- W2215900300 cites W1987995270 @default.
- W2215900300 cites W1991327193 @default.
- W2215900300 cites W1992547314 @default.
- W2215900300 cites W2005633976 @default.
- W2215900300 cites W2010277592 @default.
- W2215900300 cites W2012397253 @default.
- W2215900300 cites W2024003504 @default.
- W2215900300 cites W2027259929 @default.
- W2215900300 cites W2028621596 @default.
- W2215900300 cites W2031400018 @default.
- W2215900300 cites W2034580669 @default.
- W2215900300 cites W2035308484 @default.
- W2215900300 cites W2037012457 @default.
- W2215900300 cites W2037602102 @default.
- W2215900300 cites W2038796248 @default.
- W2215900300 cites W2041454039 @default.
- W2215900300 cites W2069969637 @default.
- W2215900300 cites W2071306094 @default.
- W2215900300 cites W2072175441 @default.
- W2215900300 cites W2076585510 @default.
- W2215900300 cites W2081577203 @default.
- W2215900300 cites W2089728963 @default.
- W2215900300 cites W2090136445 @default.
- W2215900300 cites W2093007420 @default.
- W2215900300 cites W2105589124 @default.
- W2215900300 cites W2115439624 @default.
- W2215900300 cites W2127256052 @default.
- W2215900300 cites W2136510151 @default.
- W2215900300 cites W2140427960 @default.
- W2215900300 cites W2149183402 @default.
- W2215900300 cites W2150642871 @default.
- W2215900300 cites W2152752812 @default.
- W2215900300 cites W2165328654 @default.
- W2215900300 cites W2315057398 @default.
- W2215900300 cites W2324503525 @default.
- W2215900300 cites W2335436304 @default.
- W2215900300 cites W2415825966 @default.
- W2215900300 doi "https://doi.org/10.1016/j.colsurfb.2015.12.040" @default.
- W2215900300 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26752213" @default.
- W2215900300 hasPublicationYear "2016" @default.
- W2215900300 type Work @default.
- W2215900300 sameAs 2215900300 @default.
- W2215900300 citedByCount "60" @default.
- W2215900300 countsByYear W22159003002016 @default.
- W2215900300 countsByYear W22159003002017 @default.
- W2215900300 countsByYear W22159003002018 @default.
- W2215900300 countsByYear W22159003002019 @default.
- W2215900300 countsByYear W22159003002020 @default.
- W2215900300 countsByYear W22159003002021 @default.
- W2215900300 countsByYear W22159003002022 @default.
- W2215900300 countsByYear W22159003002023 @default.
- W2215900300 crossrefType "journal-article" @default.
- W2215900300 hasAuthorship W2215900300A5048431419 @default.
- W2215900300 hasAuthorship W2215900300A5051609522 @default.
- W2215900300 hasAuthorship W2215900300A5058838850 @default.
- W2215900300 hasAuthorship W2215900300A5065916745 @default.
- W2215900300 hasAuthorship W2215900300A5087148837 @default.
- W2215900300 hasConcept C120665830 @default.
- W2215900300 hasConcept C121332964 @default.
- W2215900300 hasConcept C127413603 @default.
- W2215900300 hasConcept C131888329 @default.
- W2215900300 hasConcept C13245373 @default.
- W2215900300 hasConcept C13965031 @default.
- W2215900300 hasConcept C146088050 @default.
- W2215900300 hasConcept C150394285 @default.
- W2215900300 hasConcept C155672457 @default.
- W2215900300 hasConcept C161790260 @default.
- W2215900300 hasConcept C162711632 @default.
- W2215900300 hasConcept C171250308 @default.
- W2215900300 hasConcept C178790620 @default.
- W2215900300 hasConcept C181389837 @default.
- W2215900300 hasConcept C185592680 @default.
- W2215900300 hasConcept C191486275 @default.
- W2215900300 hasConcept C192562407 @default.
- W2215900300 hasConcept C199529486 @default.
- W2215900300 hasConcept C2777496208 @default.
- W2215900300 hasConcept C2778250585 @default.
- W2215900300 hasConcept C2779820397 @default.
- W2215900300 hasConcept C42360764 @default.
- W2215900300 hasConcept C55493867 @default.