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- W2216040868 abstract "5 pyrazole analogs were evaluated for antifertility effects in 86 rats when fed orally 0 or 1 mg from Day 1 to 5 of pregnancy. Laparotomy was performed and the number of implantation sites were counted on Day 10. 1-carbamoyl-3-methyl-4-aryl hydrazono-(25-dimenthylphenyl) -2-pyrazolin-5-one and 1-carbamoyl-3-methyl-4-aryl hydrazono-(35-dimethylphenyl)-2-pyrazolin-5-one inhibited pregnancy in 100% and 80% of the rats respectively. The substitution of 2-ethoxyphenyl in the dimethylphenyl position inhibited pregnancy in 40% of the rats. The substitution of 4-methylphenyl or 4-ethoxphenyl exerted no antifertility effect." @default.
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- W2216040868 date "1971-07-01" @default.
- W2216040868 modified "2023-09-25" @default.
- W2216040868 title "Female antifertility compounds: structural activity relationship of pyrazole analogs." @default.
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