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- W2216159780 abstract "Background: Heart failure (HF) involves myocardial fibrosis and dysregulated angiogenesis.Objective: We explored whether biomarkers of fibrosis and angiogenesis correlate with HF severity.Methods: Biomarkers of fibrosis [procollagen types I and III (PIP and P3NP), carboxyterminal-telopeptide of type I collagen (ICTP), matrix metalloproteases (MMP2 and MMP9), tissue inhibitor of MMP1 (TIMP1)]; and angiogenesis [placental growth factor (PGF), vascular endothelial growth factor (VEGF), soluble Fms-like tyrosine kinase-1 (sFlt1)] were measured in 52 HF patients and 19 controls.Results: P3NP, ICTP, MMP2, TIMP1, PGF, and sFlt1 levels were elevated in HF, while PIP/ICTP, PGF/sFlt1, and VEGF/sFlt1 ratios were reduced. PIP/ICTP, MMP-9/TIMP1, and VEGF/sFlt1 ratios were lowest among patients with severe HF.Conclusions: Severe HF is associated with collagen breakdown and reduced angiogenesis. A multimarker approach may guide therapeutic targeting of fibrosis and angiogenesis in HF." @default.
- W2216159780 created "2016-06-24" @default.
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- W2216159780 date "2015-12-15" @default.
- W2216159780 modified "2023-10-14" @default.
- W2216159780 title "Circulating multimarker profile of patients with symptomatic heart failure supports enhanced fibrotic degradation and decreased angiogenesis" @default.
- W2216159780 cites W1676600749 @default.
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- W2216159780 cites W1968778688 @default.
- W2216159780 cites W1969734795 @default.
- W2216159780 cites W1972642539 @default.
- W2216159780 cites W1977173164 @default.
- W2216159780 cites W1991720400 @default.
- W2216159780 cites W1994830193 @default.
- W2216159780 cites W1995354197 @default.
- W2216159780 cites W2000626591 @default.
- W2216159780 cites W2000949542 @default.
- W2216159780 cites W2014894250 @default.
- W2216159780 cites W2018822308 @default.
- W2216159780 cites W2019898117 @default.
- W2216159780 cites W2024353599 @default.
- W2216159780 cites W2044910746 @default.
- W2216159780 cites W2049609455 @default.
- W2216159780 cites W2051268134 @default.
- W2216159780 cites W2057313292 @default.
- W2216159780 cites W2057386289 @default.
- W2216159780 cites W2061150769 @default.
- W2216159780 cites W2064853768 @default.
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- W2216159780 cites W2101907793 @default.
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- W2216159780 doi "https://doi.org/10.3109/1354750x.2015.1118539" @default.
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