FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2216172675> ?p ?o ?g. }

• W2216172675 endingPage "37" @default.
• W2216172675 startingPage "29" @default.
• W2216172675 abstract "Compaction of multiple-unit pellet system (MUPS) tablets has been extensively studied in the past few decades but with marginal success. This study aims to investigate the formulation and process strategies for minimizing pellet coat damage caused by compaction and elucidate the mechanism of damage sustained during the preparation of MUPS tablets in a rotary tablet press. Blends containing ethylcellulose-coated pellets and cushioning agent (spray dried aggregates of micronized lactose and mannitol), were compacted into MUPS tablets in a rotary tablet press. The effects of compaction pressure and dwell time on the physicomechanical properties of resultant MUPS tablets and extent of pellet coat damage were systematically examined. The coated pellets from various locations at the axial and radial peripheral surfaces and core of the MUPS tablets were excavated and assessed for their coat damage individually. Interestingly, for a MUPS tablet formulation which consolidates by plastic deformation, the tablet mechanical strength could be enhanced without exacerbating pellet coat damage by extending the dwell time in the compaction cycle during rotary tableting. However, the increase in compaction pressure led to faster drug release rate. The location of the coated pellets in the MUPS tablet also contributed to the extent of their coat damage, possibly due to uneven force distribution within the compact. To ensure viability of pellet coat integrity, the formation of a continuous percolating network of cushioning agent is critical and the applied compaction pressure should be less than the pellet crushing strength." @default.
• W2216172675 created "2016-06-24" @default.
• W2216172675 creator A5020074724 @default.
• W2216172675 creator A5055633019 @default.
• W2216172675 creator A5065237300 @default.
• W2216172675 date "2016-02-01" @default.
• W2216172675 modified "2023-09-24" @default.
• W2216172675 title "Formulation and process strategies to minimize coat damage for compaction of coated pellets in a rotary tablet press: A mechanistic view" @default.
• W2216172675 cites W1535521637 @default.
• W2216172675 cites W1590784435 @default.
• W2216172675 cites W1965875371 @default.
• W2216172675 cites W1974906872 @default.
• W2216172675 cites W1978761756 @default.
• W2216172675 cites W1982639947 @default.
• W2216172675 cites W1990256006 @default.
• W2216172675 cites W1993242324 @default.
• W2216172675 cites W1997582235 @default.
• W2216172675 cites W2002324059 @default.
• W2216172675 cites W2005880258 @default.
• W2216172675 cites W2006213659 @default.
• W2216172675 cites W2009631008 @default.
• W2216172675 cites W2014954526 @default.
• W2216172675 cites W2015270488 @default.
• W2216172675 cites W2017042921 @default.
• W2216172675 cites W2035548219 @default.
• W2216172675 cites W2038108827 @default.
• W2216172675 cites W2053652001 @default.
• W2216172675 cites W2053994461 @default.
• W2216172675 cites W2054684555 @default.
• W2216172675 cites W2055395650 @default.
• W2216172675 cites W2058097885 @default.
• W2216172675 cites W2087152638 @default.
• W2216172675 cites W2089563212 @default.
• W2216172675 cites W2101292275 @default.
• W2216172675 cites W2108980084 @default.
• W2216172675 cites W2110297825 @default.
• W2216172675 cites W2141345402 @default.
• W2216172675 cites W2142078781 @default.
• W2216172675 cites W2159652247 @default.
• W2216172675 cites W3022519918 @default.
• W2216172675 doi "https://doi.org/10.1016/j.ijpharm.2015.12.068" @default.
• W2216172675 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26748363" @default.
• W2216172675 hasPublicationYear "2016" @default.
• W2216172675 type Work @default.
• W2216172675 sameAs 2216172675 @default.
• W2216172675 citedByCount "20" @default.
• W2216172675 countsByYear W22161726752016 @default.
• W2216172675 countsByYear W22161726752017 @default.
• W2216172675 countsByYear W22161726752018 @default.
• W2216172675 countsByYear W22161726752019 @default.
• W2216172675 countsByYear W22161726752020 @default.
• W2216172675 countsByYear W22161726752022 @default.
• W2216172675 countsByYear W22161726752023 @default.
• W2216172675 crossrefType "journal-article" @default.
• W2216172675 hasAuthorship W2216172675A5020074724 @default.
• W2216172675 hasAuthorship W2216172675A5055633019 @default.
• W2216172675 hasAuthorship W2216172675A5065237300 @default.
• W2216172675 hasConcept C159985019 @default.
• W2216172675 hasConcept C17923525 @default.
• W2216172675 hasConcept C191168616 @default.
• W2216172675 hasConcept C192562407 @default.
• W2216172675 hasConcept C196715460 @default.
• W2216172675 hasConcept C2776035855 @default.
• W2216172675 hasConcept C2779849058 @default.
• W2216172675 hasConcept C2780584874 @default.
• W2216172675 hasConcept C521977710 @default.
• W2216172675 hasConcept C5260166 @default.
• W2216172675 hasConcept C88463166 @default.
• W2216172675 hasConcept C93291783 @default.
• W2216172675 hasConceptScore W2216172675C159985019 @default.
• W2216172675 hasConceptScore W2216172675C17923525 @default.
• W2216172675 hasConceptScore W2216172675C191168616 @default.
• W2216172675 hasConceptScore W2216172675C192562407 @default.
• W2216172675 hasConceptScore W2216172675C196715460 @default.
• W2216172675 hasConceptScore W2216172675C2776035855 @default.
• W2216172675 hasConceptScore W2216172675C2779849058 @default.
• W2216172675 hasConceptScore W2216172675C2780584874 @default.
• W2216172675 hasConceptScore W2216172675C521977710 @default.
• W2216172675 hasConceptScore W2216172675C5260166 @default.
• W2216172675 hasConceptScore W2216172675C88463166 @default.
• W2216172675 hasConceptScore W2216172675C93291783 @default.
• W2216172675 hasIssue "1-2" @default.
• W2216172675 hasLocation W22161726751 @default.
• W2216172675 hasLocation W22161726752 @default.
• W2216172675 hasOpenAccess W2216172675 @default.
• W2216172675 hasPrimaryLocation W22161726751 @default.
• W2216172675 hasRelatedWork W1992378181 @default.
• W2216172675 hasRelatedWork W2008452614 @default.
• W2216172675 hasRelatedWork W2038905221 @default.
• W2216172675 hasRelatedWork W2054993626 @default.
• W2216172675 hasRelatedWork W2069706481 @default.
• W2216172675 hasRelatedWork W2096618333 @default.
• W2216172675 hasRelatedWork W2182569004 @default.
• W2216172675 hasRelatedWork W2216172675 @default.
• W2216172675 hasRelatedWork W2763859111 @default.
• W2216172675 hasRelatedWork W3027325485 @default.
• W2216172675 hasVolume "499" @default.
• W2216172675 isParatext "false" @default.

• next