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• W2216173657 endingPage "L282" @default.
• W2216173657 startingPage "L273" @default.
• W2216173657 abstract "The present study was undertaken to determine whether rat carotid bodies express adenosine (Ado) A 2A receptors and whether this receptor is involved in the cellular response to hypoxia. Our results demonstrate that rat carotid bodies express the A 2A and A 2B Ado receptor mRNAs but not the A 1 or A 3 receptor mRNAs as determined by reverse transcriptase-polymerase chain reaction. In situ hybridization confirmed the expression of the A 2A receptor mRNA. Immunohistochemical studies further showed that the A 2A receptor is expressed in the carotid body and that it is colocalized with tyrosine hydroxylase in type I cells. Whole cell voltage-clamp studies using isolated type I cells showed that Ado inhibited the voltage-dependent Ca 2+ currents and that this inhibition was abolished by the selective A 2A receptor antagonist ZM-241385. Ca 2+ imaging studies using fura 2 revealed that exposure to severe hypoxia induced elevation of intracellular Ca 2+ concentration ([Ca 2+ ] i ) in type I cells and that extracellularly applied Ado significantly attenuated the hypoxia-induced elevation of [Ca 2+ ] i . Taken together, our findings indicate that A 2A receptors are present in type I cells and that activation of A 2A receptors modulates Ca 2+ accumulation during hypoxia. This mechanism may play a role in regulating intracellular Ca 2+ homeostasis and cellular excitability during hypoxia." @default.
• W2216173657 created "2016-06-24" @default.
• W2216173657 creator A5010840211 @default.
• W2216173657 creator A5015632287 @default.
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• W2216173657 date "2000-08-01" @default.
• W2216173657 modified "2023-10-15" @default.
• W2216173657 title "Gene expression and function of adenosine A_2A receptor in the rat carotid body" @default.
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• W2216173657 doi "https://doi.org/10.1152/ajplung.2000.279.2.l273" @default.
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