FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2216177570> ?p ?o ?g. }

• W2216177570 endingPage "h6544" @default.
• W2216177570 startingPage "h6544" @default.
• W2216177570 abstract "<b>Study question</b> Can treatment of the symptoms of uncomplicated urinary tract infection (UTI) with ibuprofen reduce the rate of antibiotic prescriptions without a significant increase in symptoms, recurrences, or complications? <b>Methods</b> Women aged 18-65 with typical symptoms of UTI and without risk factors or complications were recruited in 42 German general practices and randomly assigned to treatment with a single dose of fosfomycin 3 g (n=246; 243 analysed) or ibuprofen 3×400 mg (n=248; 241 analysed) for three days (and the respective placebo dummies in both groups). In both groups additional antibiotic treatment was subsequently prescribed as necessary for persistent, worsening, or recurrent symptoms. The primary endpoints were the number of all courses of antibiotic treatment on days 0-28 (for UTI or other conditions) and burden of symptoms on days 0-7. The symptom score included dysuria, frequency/urgency, and low abdominal pain. <b>Study answer and limitations</b> The 248 women in the ibuprofen group received significantly fewer course of antibiotics, had a significantly higher total burden of symptoms, and more had pyelonephritis. Four serious adverse events occurred that lead to hospital referrals; one of these was potentially related to the trial drug. Results have to be interpreted carefully as they might apply to women with mild to moderate symptoms rather than to all those with an uncomplicated UTI. <b>What this paper adds</b> Two thirds of women with uncomplicated UTI treated symptomatically with ibuprofen recovered without any antibiotics. Initial symptomatic treatment is a possible approach to be discussed with women willing to avoid immediate antibiotics and to accept a somewhat higher burden of symptoms. <b>Funding, competing interests, data sharing</b> German Federal Ministry of Education and Research (BMBF) No 01KG1105. Patient level data are available from the corresponding author. Patient consent was not obtained but the data are anonymised and risk of identification is low. <b>Trial registration No</b> ClinicalTrialGov Identifier NCT01488955." @default.
• W2216177570 created "2016-06-24" @default.
• W2216177570 creator A5035891368 @default.
• W2216177570 creator A5036909773 @default.
• W2216177570 creator A5049355867 @default.
• W2216177570 creator A5059322051 @default.
• W2216177570 creator A5072985433 @default.
• W2216177570 creator A5091797466 @default.
• W2216177570 date "2015-12-23" @default.
• W2216177570 modified "2023-10-15" @default.
• W2216177570 title "Ibuprofen versus fosfomycin for uncomplicated urinary tract infection in women: randomised controlled trial" @default.
• W2216177570 cites W1931781407 @default.
• W2216177570 cites W1976901009 @default.
• W2216177570 cites W1996153338 @default.
• W2216177570 cites W1997539987 @default.
• W2216177570 cites W2010355287 @default.
• W2216177570 cites W2034525803 @default.
• W2216177570 cites W2034781418 @default.
• W2216177570 cites W2040960469 @default.
• W2216177570 cites W2044362992 @default.
• W2216177570 cites W2059495152 @default.
• W2216177570 cites W2089754545 @default.
• W2216177570 cites W2097600612 @default.
• W2216177570 cites W2097807888 @default.
• W2216177570 cites W2098914200 @default.
• W2216177570 cites W2101182625 @default.
• W2216177570 cites W2111720735 @default.
• W2216177570 cites W2112155849 @default.
• W2216177570 cites W2113565511 @default.
• W2216177570 cites W2118569344 @default.
• W2216177570 cites W2123200052 @default.
• W2216177570 cites W2123572561 @default.
• W2216177570 cites W2129628855 @default.
• W2216177570 cites W2133579709 @default.
• W2216177570 cites W2135119076 @default.
• W2216177570 cites W2150696664 @default.
• W2216177570 cites W2152311597 @default.
• W2216177570 cites W2153333998 @default.
• W2216177570 cites W2156770798 @default.
• W2216177570 cites W2164684313 @default.
• W2216177570 cites W2165296911 @default.
• W2216177570 cites W4236345567 @default.
• W2216177570 doi "https://doi.org/10.1136/bmj.h6544" @default.
• W2216177570 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4688879" @default.
• W2216177570 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26698878" @default.
• W2216177570 hasPublicationYear "2015" @default.
• W2216177570 type Work @default.
• W2216177570 sameAs 2216177570 @default.
• W2216177570 citedByCount "206" @default.
• W2216177570 countsByYear W22161775702015 @default.
• W2216177570 countsByYear W22161775702016 @default.
• W2216177570 countsByYear W22161775702017 @default.
• W2216177570 countsByYear W22161775702018 @default.
• W2216177570 countsByYear W22161775702019 @default.
• W2216177570 countsByYear W22161775702020 @default.
• W2216177570 countsByYear W22161775702021 @default.
• W2216177570 countsByYear W22161775702022 @default.
• W2216177570 countsByYear W22161775702023 @default.
• W2216177570 crossrefType "journal-article" @default.
• W2216177570 hasAuthorship W2216177570A5035891368 @default.
• W2216177570 hasAuthorship W2216177570A5036909773 @default.
• W2216177570 hasAuthorship W2216177570A5049355867 @default.
• W2216177570 hasAuthorship W2216177570A5059322051 @default.
• W2216177570 hasAuthorship W2216177570A5072985433 @default.
• W2216177570 hasAuthorship W2216177570A5091797466 @default.
• W2216177570 hasBestOaLocation W22161775701 @default.
• W2216177570 hasConcept C126322002 @default.
• W2216177570 hasConcept C142724271 @default.
• W2216177570 hasConcept C168563851 @default.
• W2216177570 hasConcept C197934379 @default.
• W2216177570 hasConcept C204787440 @default.
• W2216177570 hasConcept C2426938 @default.
• W2216177570 hasConcept C27081682 @default.
• W2216177570 hasConcept C2776845205 @default.
• W2216177570 hasConcept C2777785397 @default.
• W2216177570 hasConcept C2778897966 @default.
• W2216177570 hasConcept C2779944601 @default.
• W2216177570 hasConcept C2780955771 @default.
• W2216177570 hasConcept C501593827 @default.
• W2216177570 hasConcept C71924100 @default.
• W2216177570 hasConcept C77411442 @default.
• W2216177570 hasConcept C86803240 @default.
• W2216177570 hasConcept C89423630 @default.
• W2216177570 hasConcept C98274493 @default.
• W2216177570 hasConceptScore W2216177570C126322002 @default.
• W2216177570 hasConceptScore W2216177570C142724271 @default.
• W2216177570 hasConceptScore W2216177570C168563851 @default.
• W2216177570 hasConceptScore W2216177570C197934379 @default.
• W2216177570 hasConceptScore W2216177570C204787440 @default.
• W2216177570 hasConceptScore W2216177570C2426938 @default.
• W2216177570 hasConceptScore W2216177570C27081682 @default.
• W2216177570 hasConceptScore W2216177570C2776845205 @default.
• W2216177570 hasConceptScore W2216177570C2777785397 @default.
• W2216177570 hasConceptScore W2216177570C2778897966 @default.
• W2216177570 hasConceptScore W2216177570C2779944601 @default.
• W2216177570 hasConceptScore W2216177570C2780955771 @default.
• W2216177570 hasConceptScore W2216177570C501593827 @default.
• W2216177570 hasConceptScore W2216177570C71924100 @default.

• next