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• W2216350057 abstract "The BTB-POZ transcription factor Promyelocytic Leukemia Zinc Finger (PLZF, or ZBTB16) has been recently identified as a major factor regulating the induction of a subset of Interferon stimulated genes in human and mouse. We show that the two co-orthologues of PLZF found in zebrafish show distinct expression patterns, especially in larvae. Although zbtb16a/plzfa and zbtb16b/plzfb are not modulated by IFN produced during viral infection, their over-expression increases the level of the early type I IFN response, at a critical phase in the race between the virus and the host response. The effect of Plzfb on IFN induction was also detectable after cell infection by different non-enveloped RNA viruses, but not after infection by the rhabdovirus SVCV. Our findings indicate that plzf implication in the regulation of type I IFN responses is conserved across vertebrates, but at multiple levels of the pathway and through different mechanisms." @default.
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• W2216350057 date "2016-04-01" @default.
• W2216350057 modified "2023-09-26" @default.
• W2216350057 title "Zebrafish Plzf transcription factors enhance early type I IFN response induced by two non-enveloped RNA viruses" @default.
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• W2216350057 doi "https://doi.org/10.1016/j.dci.2015.12.016" @default.
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