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- W2216389216 endingPage "18" @default.
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- W2216389216 abstract "Many diseases are associated with protein species perturbations. A prominent example of an established diagnostic marker is the glycated protein species of hemoglobin, termed HbA1c. HbA1c concentration is increased in the blood of diabetes mellitus patients due to their poor control of blood glucose levels resulting in an increased non-enzymatic glycosylation of hemoglobin producing HbA1c. This important diagnostic marker is routinely measured in the blood of diabetes patients. As in the case of HbA1c, protein species can mirror pathophysiological events. Shifts in the levels of protein species can be associated with or even be responsible for disease making them well suited as diagnostic markers. However, only a few protein species are currently used as diagnostic markers in routine clinical chemistry laboratories, despite being widely established in clinical proteomics research. This review provides an overview of the biochemical characteristics associated with protein species as well as examples of pathophysiological mechanisms, which cause modifications in the protein species composition, thereby emphasizing the importance of screening for protein markers at the species level. Further, we highlight techniques, which are currently utilized for investigating protein species markers in clinical research.The success rate of FDA approved diagnostic protein markers until today is very low compared to the number of published candidate disease markers. It is hypothesized that one important reason is the gene-centric view which is still followed in clinical proteomics: In many investigations proteins are still digested in small peptides thus making it nearly impossible to discriminate between healthy proteins and pathologic proteins causing diseases. Thus this review is focusing on the biochemistry and patho-biochemistry of proteins, is highlighting the need for screening for disease markers on the protein species level and is giving an overview about available techniques." @default.
- W2216389216 created "2016-06-24" @default.
- W2216389216 creator A5037776901 @default.
- W2216389216 creator A5038669836 @default.
- W2216389216 creator A5044931187 @default.
- W2216389216 creator A5045617842 @default.
- W2216389216 creator A5079773811 @default.
- W2216389216 creator A5082288933 @default.
- W2216389216 creator A5088017962 @default.
- W2216389216 date "2016-02-01" @default.
- W2216389216 modified "2023-09-27" @default.
- W2216389216 title "Protein species as diagnostic markers" @default.
- W2216389216 cites W1480858518 @default.
- W2216389216 cites W1492046083 @default.
- W2216389216 cites W1495719268 @default.
- W2216389216 cites W1520566045 @default.
- W2216389216 cites W1530138639 @default.
- W2216389216 cites W1533601163 @default.
- W2216389216 cites W1539565722 @default.
- W2216389216 cites W1568341953 @default.
- W2216389216 cites W1582753604 @default.
- W2216389216 cites W1589300752 @default.
- W2216389216 cites W1760204652 @default.
- W2216389216 cites W178305797 @default.
- W2216389216 cites W1912465182 @default.
- W2216389216 cites W1929741474 @default.
- W2216389216 cites W1960864063 @default.
- W2216389216 cites W1964532554 @default.
- W2216389216 cites W1964753682 @default.
- W2216389216 cites W1964946814 @default.
- W2216389216 cites W1965341129 @default.
- W2216389216 cites W1965807926 @default.
- W2216389216 cites W1965868856 @default.
- W2216389216 cites W1965956646 @default.
- W2216389216 cites W1966250622 @default.
- W2216389216 cites W1966686525 @default.
- W2216389216 cites W1970133737 @default.
- W2216389216 cites W1971092625 @default.
- W2216389216 cites W1976009407 @default.
- W2216389216 cites W1977502249 @default.
- W2216389216 cites W1979258878 @default.
- W2216389216 cites W1980476482 @default.
- W2216389216 cites W1983480089 @default.
- W2216389216 cites W1984403117 @default.
- W2216389216 cites W1984589199 @default.
- W2216389216 cites W1987653653 @default.
- W2216389216 cites W1987761159 @default.
- W2216389216 cites W1989125189 @default.
- W2216389216 cites W1989841960 @default.
- W2216389216 cites W1991367299 @default.
- W2216389216 cites W1993428041 @default.
- W2216389216 cites W1994245422 @default.
- W2216389216 cites W1995286508 @default.
- W2216389216 cites W1995995495 @default.
- W2216389216 cites W1996393304 @default.
- W2216389216 cites W1997550446 @default.
- W2216389216 cites W1998379582 @default.
- W2216389216 cites W1998907758 @default.
- W2216389216 cites W1998969417 @default.
- W2216389216 cites W2000686310 @default.
- W2216389216 cites W2003378728 @default.
- W2216389216 cites W2003820980 @default.
- W2216389216 cites W2004236352 @default.
- W2216389216 cites W2008218157 @default.
- W2216389216 cites W2009660848 @default.
- W2216389216 cites W2011126405 @default.
- W2216389216 cites W2012494258 @default.
- W2216389216 cites W2012671659 @default.
- W2216389216 cites W2012948528 @default.
- W2216389216 cites W2013069011 @default.
- W2216389216 cites W2014083041 @default.
- W2216389216 cites W2015214203 @default.
- W2216389216 cites W2015704152 @default.
- W2216389216 cites W2016432437 @default.
- W2216389216 cites W2018840890 @default.
- W2216389216 cites W2019301043 @default.
- W2216389216 cites W2021035046 @default.
- W2216389216 cites W2021206018 @default.
- W2216389216 cites W2023404433 @default.
- W2216389216 cites W2024459158 @default.
- W2216389216 cites W2024621114 @default.
- W2216389216 cites W2025714022 @default.
- W2216389216 cites W2025963352 @default.
- W2216389216 cites W2026375432 @default.
- W2216389216 cites W2026783122 @default.
- W2216389216 cites W2027572771 @default.
- W2216389216 cites W2027869001 @default.
- W2216389216 cites W2028089076 @default.
- W2216389216 cites W2028935714 @default.
- W2216389216 cites W2031488930 @default.
- W2216389216 cites W2033159891 @default.
- W2216389216 cites W2033442376 @default.
- W2216389216 cites W2034108516 @default.
- W2216389216 cites W2035037428 @default.
- W2216389216 cites W2035062331 @default.
- W2216389216 cites W2035081205 @default.
- W2216389216 cites W2037078037 @default.
- W2216389216 cites W2037325627 @default.