Matches in SemOpenAlex for { <https://semopenalex.org/work/W2216402574> ?p ?o ?g. }
- W2216402574 endingPage "91" @default.
- W2216402574 startingPage "83" @default.
- W2216402574 abstract "In the past, vitamin D was known for its classical, skeletal action as a regulator of calcium and bone homoeostasis. Currently, vitamin D was found to have a role in numerous physiological processes in the human body; thus, vitamin D has pleiotropic activity. The studies carried out in the past two decades showed the role of vitamin D in the regulation of immune system functions. Basically, these effects may be mediated not only via endocrine mechanism of circulating calcitriol but also via paracrine one (based on cell–cell communication that leads to production of signal inducing the changes in nearby/adjacent cells and modulating their differentiation or behaviour) and intracrine mechanism (the action of vitamin D inside a cell) of 1,25-dihydroxycholecalciferol (1,25(OH)2D3) synthetized from its precursor 25-hydroxyvitamin D3 (25(OH)D3). Both vitamin D receptor (VDR) and 25-hydroxyvitamin D3 1-α-hydroxylase (CYP27B1) are expressed in several types of immune cells (i.e. antigen presenting cells, T and B cells), and thus, they are able to synthetize the bioactive form of vitamin D that modulates both the innate and adaptive immune system. This review discusses the role of vitamin D as regulator of immune system, and our understanding of how vitamin D regulates both adaptive and innate immunity as well as inflammatory cascade on the cellular level." @default.
- W2216402574 created "2016-06-24" @default.
- W2216402574 creator A5069697575 @default.
- W2216402574 creator A5079438400 @default.
- W2216402574 date "2016-01-28" @default.
- W2216402574 modified "2023-10-05" @default.
- W2216402574 title "The Active Metabolite of Vitamin D<sub>3</sub>as a Potential Immunomodulator" @default.
- W2216402574 cites W1524173996 @default.
- W2216402574 cites W1551028857 @default.
- W2216402574 cites W1579451442 @default.
- W2216402574 cites W1579673144 @default.
- W2216402574 cites W1645379154 @default.
- W2216402574 cites W1661544713 @default.
- W2216402574 cites W1663317712 @default.
- W2216402574 cites W1834677809 @default.
- W2216402574 cites W1860888551 @default.
- W2216402574 cites W1866685620 @default.
- W2216402574 cites W1909439607 @default.
- W2216402574 cites W1943160106 @default.
- W2216402574 cites W1963871427 @default.
- W2216402574 cites W1968870913 @default.
- W2216402574 cites W1972181361 @default.
- W2216402574 cites W1972945473 @default.
- W2216402574 cites W1975593226 @default.
- W2216402574 cites W1975876211 @default.
- W2216402574 cites W1978110685 @default.
- W2216402574 cites W1978214647 @default.
- W2216402574 cites W1982020401 @default.
- W2216402574 cites W1983885843 @default.
- W2216402574 cites W1985558958 @default.
- W2216402574 cites W1995543125 @default.
- W2216402574 cites W1996321010 @default.
- W2216402574 cites W1998821360 @default.
- W2216402574 cites W2006083207 @default.
- W2216402574 cites W2007331929 @default.
- W2216402574 cites W2007751085 @default.
- W2216402574 cites W2013093284 @default.
- W2216402574 cites W2013761623 @default.
- W2216402574 cites W2017335874 @default.
- W2216402574 cites W2018938924 @default.
- W2216402574 cites W2021490026 @default.
- W2216402574 cites W2024976212 @default.
- W2216402574 cites W2031746740 @default.
- W2216402574 cites W2035986671 @default.
- W2216402574 cites W2036088433 @default.
- W2216402574 cites W2036586400 @default.
- W2216402574 cites W2036981005 @default.
- W2216402574 cites W2038177382 @default.
- W2216402574 cites W2043612033 @default.
- W2216402574 cites W2046473453 @default.
- W2216402574 cites W2052505493 @default.
- W2216402574 cites W2052561467 @default.
- W2216402574 cites W2057940509 @default.
- W2216402574 cites W2058052793 @default.
- W2216402574 cites W2060061638 @default.
- W2216402574 cites W2062254683 @default.
- W2216402574 cites W2064257381 @default.
- W2216402574 cites W2064362489 @default.
- W2216402574 cites W2068125451 @default.
- W2216402574 cites W2069971522 @default.
- W2216402574 cites W2075552579 @default.
- W2216402574 cites W2079080809 @default.
- W2216402574 cites W2080076458 @default.
- W2216402574 cites W2084954530 @default.
- W2216402574 cites W2087705083 @default.
- W2216402574 cites W2091957879 @default.
- W2216402574 cites W2095053527 @default.
- W2216402574 cites W2097027689 @default.
- W2216402574 cites W2099126377 @default.
- W2216402574 cites W2104440580 @default.
- W2216402574 cites W2104754533 @default.
- W2216402574 cites W2106044877 @default.
- W2216402574 cites W2106449126 @default.
- W2216402574 cites W2106606013 @default.
- W2216402574 cites W2107306983 @default.
- W2216402574 cites W2108086395 @default.
- W2216402574 cites W2108825111 @default.
- W2216402574 cites W2114216755 @default.
- W2216402574 cites W2116296059 @default.
- W2216402574 cites W2116654815 @default.
- W2216402574 cites W2117075813 @default.
- W2216402574 cites W2117342258 @default.
- W2216402574 cites W2118582534 @default.
- W2216402574 cites W2118889444 @default.
- W2216402574 cites W2119739932 @default.
- W2216402574 cites W2123944413 @default.
- W2216402574 cites W2124085914 @default.
- W2216402574 cites W2124580054 @default.
- W2216402574 cites W2133215874 @default.
- W2216402574 cites W2133378877 @default.
- W2216402574 cites W2134642063 @default.
- W2216402574 cites W2135604027 @default.
- W2216402574 cites W2143219578 @default.
- W2216402574 cites W2149425411 @default.
- W2216402574 cites W2150081739 @default.
- W2216402574 cites W2150620680 @default.
- W2216402574 cites W2150990505 @default.
- W2216402574 cites W2151176594 @default.