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- W2216452803 abstract "The yeast Saccharomyces cerevisiae produces a peptide pheromone, termed the alpha-factor, as a prelude to sexual conjugation. Haploid MAT alpha-cells, but not haploid MAT a-cells or MAT a/alpha-diploids, produce this tridecapeptide of the structure: Trp-His-Trp-Leu-Gln-Leu-Lys-Pro-Gly-Gln-Pro-Met-Tyr. Structural analogues of the alpha-factor have been prepared with alterations in many of the residues, derivatized peptides have been synthesized, and truncated and elongated peptides have been studied. These peptides have been analyzed for their biological activities by various assays. Mutants of S. cerevisiae have been isolated that do not respond to alpha-factor or are supersensitive to the pheromone and its analogues. The mating system of S. cerevisiae provides a powerful model in which genetics, biochemistry, and molecular biology can be used to unravel the mysteries of peptide hormone structure and function." @default.
- W2216452803 created "2016-06-24" @default.
- W2216452803 creator A5042774299 @default.
- W2216452803 creator A5044184936 @default.
- W2216452803 date "1986-01-01" @default.
- W2216452803 modified "2023-09-26" @default.
- W2216452803 title "Structure-Activity Relationships of the Yeast α-Facto" @default.
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- W2216452803 doi "https://doi.org/10.3109/10409238609113612" @default.
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