FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2216495655> ?p ?o ?g. }

• W2216495655 abstract "Cardiovascular involvement represents a leading cause of mortality and morbidity in sickle cell disease (SCD). Apelin is a peptide involved in the regulation of cardiovascular function.To determine serum apelin among 40 children and adolescents with SCD compared with 40 healthy controls and assess its relation to markers of hemolysis, iron overload as well as cardiopulmonary complications.SCD patients, in steady state and asymptomatic for heart disease, were studied stressing on hydroxyurea/chelation therapy, hematological profile, serum ferritin and apelin levels. Full echocardiographic study including assessment of biventricular systolic function and pulmonary artery pressure was done.Apelin levels were significantly lower in SCD patients compared with controls (P<0.001). Cardiopulmonary complications were encountered in 30% of patients. Apelin was significantly decreased among patients with cardiopulmonary disease (P=0.006) whether those at risk of pulmonary hypertension (P=0.018) or patients with heart disease (P=0.043). Hydroxyurea-treated patients had higher apelin levels than untreated ones (P=0.001). Apelin was negatively correlated to lactate dehydrogenase, indirect bilirubin, serum ferritin, end systolic diameter, tricuspid regurgitant jet velocity, right ventricle systolic pressure, pulmonary vascular resistance and tissue Doppler imaging S wave. Apelin cutoff value of 1650ng/L could significantly detect the presence of cardiopulmonary complications in SCD with 90.9% sensitivity and 72.4% specificity.Apelin is a promising marker for screening of SCD patients at risk of cardiopulmonary disease because it is altered during the early subclinical stage of cardiac affection. A combination of apelin and echocardiography provides a reliable method to assess cardiopulmonary affection in young SCD patients." @default.
• W2216495655 created "2016-06-24" @default.
• W2216495655 creator A5007021346 @default.
• W2216495655 creator A5025725556 @default.
• W2216495655 creator A5041370545 @default.
• W2216495655 creator A5045501876 @default.
• W2216495655 date "2016-03-01" @default.
• W2216495655 modified "2023-09-26" @default.
• W2216495655 title "Serum apelin as a novel non-invasive marker for subclinical cardiopulmonary complications in children and adolescents with sickle cell disease" @default.
• W2216495655 cites W1963976067 @default.
• W2216495655 cites W1968642156 @default.
• W2216495655 cites W1976726694 @default.
• W2216495655 cites W1976799894 @default.
• W2216495655 cites W1982861332 @default.
• W2216495655 cites W1985044674 @default.
• W2216495655 cites W2004689098 @default.
• W2216495655 cites W2011201992 @default.
• W2216495655 cites W2014093734 @default.
• W2216495655 cites W2014447414 @default.
• W2216495655 cites W2020905941 @default.
• W2216495655 cites W2022769184 @default.
• W2216495655 cites W2023285558 @default.
• W2216495655 cites W2027554054 @default.
• W2216495655 cites W2033357297 @default.
• W2216495655 cites W2039651623 @default.
• W2216495655 cites W2040323431 @default.
• W2216495655 cites W2040708681 @default.
• W2216495655 cites W2049292864 @default.
• W2216495655 cites W2053495832 @default.
• W2216495655 cites W2060660919 @default.
• W2216495655 cites W2063080769 @default.
• W2216495655 cites W2066567310 @default.
• W2216495655 cites W2067365515 @default.
• W2216495655 cites W2069333438 @default.
• W2216495655 cites W2071771677 @default.
• W2216495655 cites W2077198654 @default.
• W2216495655 cites W20888778 @default.
• W2216495655 cites W2100220436 @default.
• W2216495655 cites W2108644172 @default.
• W2216495655 cites W2109712401 @default.
• W2216495655 cites W2116340717 @default.
• W2216495655 cites W2117196163 @default.
• W2216495655 cites W2119340816 @default.
• W2216495655 cites W2123161963 @default.
• W2216495655 cites W2146578470 @default.
• W2216495655 cites W2147182596 @default.
• W2216495655 cites W2148547093 @default.
• W2216495655 cites W2158310000 @default.
• W2216495655 cites W2170793571 @default.
• W2216495655 cites W2172072865 @default.
• W2216495655 cites W2313326603 @default.
• W2216495655 cites W2313541759 @default.
• W2216495655 cites W2322074970 @default.
• W2216495655 cites W2326476344 @default.
• W2216495655 cites W2361666145 @default.
• W2216495655 cites W50870326 @default.
• W2216495655 cites W2470191753 @default.
• W2216495655 cites W3144957394 @default.
• W2216495655 doi "https://doi.org/10.1016/j.bcmd.2015.11.001" @default.
• W2216495655 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26852648" @default.
• W2216495655 hasPublicationYear "2016" @default.
• W2216495655 type Work @default.
• W2216495655 sameAs 2216495655 @default.
• W2216495655 citedByCount "2" @default.
• W2216495655 countsByYear W22164956552019 @default.
• W2216495655 countsByYear W22164956552023 @default.
• W2216495655 crossrefType "journal-article" @default.
• W2216495655 hasAuthorship W2216495655A5007021346 @default.
• W2216495655 hasAuthorship W2216495655A5025725556 @default.
• W2216495655 hasAuthorship W2216495655A5041370545 @default.
• W2216495655 hasAuthorship W2216495655A5045501876 @default.
• W2216495655 hasConcept C113280763 @default.
• W2216495655 hasConcept C126322002 @default.
• W2216495655 hasConcept C164705383 @default.
• W2216495655 hasConcept C170493617 @default.
• W2216495655 hasConcept C2777910003 @default.
• W2216495655 hasConcept C2779546753 @default.
• W2216495655 hasConcept C2780930700 @default.
• W2216495655 hasConcept C71924100 @default.
• W2216495655 hasConceptScore W2216495655C113280763 @default.
• W2216495655 hasConceptScore W2216495655C126322002 @default.
• W2216495655 hasConceptScore W2216495655C164705383 @default.
• W2216495655 hasConceptScore W2216495655C170493617 @default.
• W2216495655 hasConceptScore W2216495655C2777910003 @default.
• W2216495655 hasConceptScore W2216495655C2779546753 @default.
• W2216495655 hasConceptScore W2216495655C2780930700 @default.
• W2216495655 hasConceptScore W2216495655C71924100 @default.
• W2216495655 hasLocation W22164956551 @default.
• W2216495655 hasLocation W22164956552 @default.
• W2216495655 hasOpenAccess W2216495655 @default.
• W2216495655 hasPrimaryLocation W22164956551 @default.
• W2216495655 hasRelatedWork W1995343244 @default.
• W2216495655 hasRelatedWork W2004016166 @default.
• W2216495655 hasRelatedWork W2049906513 @default.
• W2216495655 hasRelatedWork W2057721052 @default.
• W2216495655 hasRelatedWork W2096453380 @default.
• W2216495655 hasRelatedWork W2247144129 @default.
• W2216495655 hasRelatedWork W2470137109 @default.
• W2216495655 hasRelatedWork W2737807672 @default.
• W2216495655 hasRelatedWork W3107464949 @default.

• next