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- W2216546904 abstract "Ischemia and reperfusion injury (IRI) in the liver, a major complication of hemorrhagic shock, resection and transplantation, is a dynamic process that involves two interrelated phases of ischemic damage and inflammation-mediated reperfusion injury. Multiple cellular and molecular pathways regulate tissue damage, and integration of different players into a unified mechanism is warranted. Here, we focus on recent progress in the mechanism of liver innate immune activation by IR. Kupffer cells, dendritic cells, NK, as well as T cells initiate local inflammation response, the hallmark of IRI, by utilizing distinctive immune receptors to recognize various molecules, both endogenous and exogenous. The interlocked molecular signaling pathways in multiple liver cell types, the IRI kinetics, and positive versus negative regulatory loops in the innate immune activation are discussed. Better appreciation of molecular interactions that mediate these cascades should allow for the development of much needed novel therapeutic approaches against IRI in transplant recipients." @default.
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- W2216546904 date "2013-01-01" @default.
- W2216546904 modified "2023-10-18" @default.
- W2216546904 title "Innate-Adaptive Immune Responses in Organ Ischemia/Reperfusion Injury" @default.
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- W2216546904 doi "https://doi.org/10.1159/000346527" @default.
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