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- W2216572574 endingPage "207" @default.
- W2216572574 startingPage "195" @default.
- W2216572574 abstract "Common variable immunodeficiency (CVID) is the most frequent symptomatic primary immune deficiency and is characterized by hypogammaglobulinemia, defect in specific antibody response and increased susceptibility to recurrent infections, malignancy and autoimmunity. Patients with CVID often have defects in post-antigenic B-cell differentiation, with fewer memory B cells and impaired isotype switching. Toll-like receptors (TLRs) are expressed on various immune cells as key elements of innate and adaptive immunity. TLR signaling in B cells plays multiple roles in cell differentiation and activation, class-switch recombination and cytokine and antibody production. Moreover, recent studies have shown functional alteration of TLRs responses in CVID patients including poor cell proliferation, impaired upregulation of co-stimulatory molecules and failure in cytokine and immunoglobulin production. The purpose of the present review is to discuss the role of TLRs in B-cell development and function as well as their role in the immunopathogenesis of CVID." @default.
- W2216572574 created "2016-06-24" @default.
- W2216572574 creator A5014591284 @default.
- W2216572574 creator A5016320625 @default.
- W2216572574 creator A5032305525 @default.
- W2216572574 creator A5040499257 @default.
- W2216572574 creator A5043880029 @default.
- W2216572574 creator A5052050053 @default.
- W2216572574 creator A5057262090 @default.
- W2216572574 creator A5081834881 @default.
- W2216572574 date "2015-12-14" @default.
- W2216572574 modified "2023-10-14" @default.
- W2216572574 title "The role of toll-like receptors in B-cell development and immunopathogenesis of common variable immunodeficiency" @default.
- W2216572574 cites W1492715436 @default.
- W2216572574 cites W1514339684 @default.
- W2216572574 cites W1541663213 @default.
- W2216572574 cites W1551673968 @default.
- W2216572574 cites W1564941126 @default.
- W2216572574 cites W1567404114 @default.
- W2216572574 cites W1598212950 @default.
- W2216572574 cites W1655860314 @default.
- W2216572574 cites W1757731638 @default.
- W2216572574 cites W1798949989 @default.
- W2216572574 cites W1803235449 @default.
- W2216572574 cites W1841150905 @default.
- W2216572574 cites W1853957385 @default.
- W2216572574 cites W1882673640 @default.
- W2216572574 cites W1900497786 @default.
- W2216572574 cites W1908619457 @default.
- W2216572574 cites W1910692743 @default.
- W2216572574 cites W1918084944 @default.
- W2216572574 cites W1918941126 @default.
- W2216572574 cites W1919093559 @default.
- W2216572574 cites W1950612873 @default.
- W2216572574 cites W1965763900 @default.
- W2216572574 cites W1970839833 @default.
- W2216572574 cites W1972191082 @default.
- W2216572574 cites W1972564604 @default.
- W2216572574 cites W1976853865 @default.
- W2216572574 cites W1977467447 @default.
- W2216572574 cites W1979133879 @default.
- W2216572574 cites W1984962444 @default.
- W2216572574 cites W1985477675 @default.
- W2216572574 cites W1985739089 @default.
- W2216572574 cites W1986097339 @default.
- W2216572574 cites W1986656940 @default.
- W2216572574 cites W1991013951 @default.
- W2216572574 cites W1991130982 @default.
- W2216572574 cites W1991974890 @default.
- W2216572574 cites W1992274022 @default.
- W2216572574 cites W1993658270 @default.
- W2216572574 cites W1994942139 @default.
- W2216572574 cites W1995045831 @default.
- W2216572574 cites W1995118424 @default.
- W2216572574 cites W1995924318 @default.
- W2216572574 cites W1996913811 @default.
- W2216572574 cites W2002694609 @default.
- W2216572574 cites W2005634587 @default.
- W2216572574 cites W2007332538 @default.
- W2216572574 cites W2008866474 @default.
- W2216572574 cites W2010746142 @default.
- W2216572574 cites W2010839448 @default.
- W2216572574 cites W2011225907 @default.
- W2216572574 cites W2013469022 @default.
- W2216572574 cites W2015245677 @default.
- W2216572574 cites W2015564999 @default.
- W2216572574 cites W2016304443 @default.
- W2216572574 cites W2017614316 @default.
- W2216572574 cites W2018943533 @default.
- W2216572574 cites W2019382232 @default.
- W2216572574 cites W2020732687 @default.
- W2216572574 cites W2020855096 @default.
- W2216572574 cites W2022769546 @default.
- W2216572574 cites W2023564006 @default.
- W2216572574 cites W2023718084 @default.
- W2216572574 cites W2025357775 @default.
- W2216572574 cites W2025462060 @default.
- W2216572574 cites W2026266460 @default.
- W2216572574 cites W2028682232 @default.
- W2216572574 cites W2030534966 @default.
- W2216572574 cites W2032510562 @default.
- W2216572574 cites W2033395171 @default.
- W2216572574 cites W2035451300 @default.
- W2216572574 cites W2035563321 @default.
- W2216572574 cites W2035662671 @default.
- W2216572574 cites W2037759181 @default.
- W2216572574 cites W2038267036 @default.
- W2216572574 cites W2044983161 @default.
- W2216572574 cites W2045279953 @default.
- W2216572574 cites W2045753854 @default.
- W2216572574 cites W2047759625 @default.
- W2216572574 cites W2047865956 @default.
- W2216572574 cites W2049404127 @default.
- W2216572574 cites W2050650519 @default.
- W2216572574 cites W2052997401 @default.
- W2216572574 cites W2060024106 @default.
- W2216572574 cites W2060027779 @default.
- W2216572574 cites W2065293336 @default.