FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2216743954> ?p ?o ?g. }

• W2216743954 endingPage "e0138504" @default.
• W2216743954 startingPage "e0138504" @default.
• W2216743954 abstract "The cytotoxicity effects of E. adenophorum on cell cycle and apoptosis of renal cells in Saanen goat was evaluated by TUNEL, DAPI, AO/EB staining, DNA fragmentation assay, Caspase activity, Western-blot, qRT-PCR and flow cytometry analysis. 16 saanen goats randomly divided into four groups were fed on 0%, 40%, 60% and 80% E. adenophorum diets. The Results showed that E. adenophorum induced typical apoptotic features of renal cells. E. adenophorum significantly suppressed renal cells viability, caused cell cycle activity arrest and induced typical apoptotic features in a dose-dependent manner. However, the protein levels of Fas/FasL, Bid and caspase-8 did not appear significant changes in the process of E. adenophorum-induced apoptosis. Moreover, E. adenophorum administration slightly decreased Bcl-2 expression, promoted Bax translocation to mitochondria, triggered the release of Cyt c from mitochondria into cytosol and activated caspase-9, -3, and cleaved PARP. The mitochondrial p53 translocation was significantly activated, accompanied by a significant increase in the loss of ΔΨm, Cyt c release and caspase-9 activation. Above all, these data suggest that E. adenophorum induces renal cells apoptosis via the activation of mitochondria-mediated apoptosis pathway in renal cells. These findings may provide new insights to understand the mechanisms involved in E. adenophorum-caused cytotoxicity of renal cells." @default.
• W2216743954 created "2016-06-24" @default.
• W2216743954 creator A5001427039 @default.
• W2216743954 creator A5002108827 @default.
• W2216743954 creator A5021495647 @default.
• W2216743954 creator A5028700388 @default.
• W2216743954 creator A5031943018 @default.
• W2216743954 creator A5032077798 @default.
• W2216743954 creator A5032147007 @default.
• W2216743954 creator A5036897434 @default.
• W2216743954 creator A5039144070 @default.
• W2216743954 creator A5042058980 @default.
• W2216743954 creator A5046663841 @default.
• W2216743954 creator A5062875328 @default.
• W2216743954 creator A5071202457 @default.
• W2216743954 creator A5075086137 @default.
• W2216743954 creator A5084769658 @default.
• W2216743954 date "2015-09-18" @default.
• W2216743954 modified "2023-10-16" @default.
• W2216743954 title "E. adenophorum Induces Cell Cycle and Apoptosis of Renal Cells through Mitochondrial Pathway and Caspase Activation in Saanen Goat" @default.
• W2216743954 cites W1875555978 @default.
• W2216743954 cites W1977258127 @default.
• W2216743954 cites W1977792103 @default.
• W2216743954 cites W1979842763 @default.
• W2216743954 cites W1979995768 @default.
• W2216743954 cites W1982789641 @default.
• W2216743954 cites W1985847583 @default.
• W2216743954 cites W1991429239 @default.
• W2216743954 cites W1995306502 @default.
• W2216743954 cites W1995858470 @default.
• W2216743954 cites W1997005484 @default.
• W2216743954 cites W1997217890 @default.
• W2216743954 cites W2001990427 @default.
• W2216743954 cites W2004085522 @default.
• W2216743954 cites W2006366929 @default.
• W2216743954 cites W2010478401 @default.
• W2216743954 cites W2011955718 @default.
• W2216743954 cites W2014654394 @default.
• W2216743954 cites W2032338900 @default.
• W2216743954 cites W2032750444 @default.
• W2216743954 cites W2041164315 @default.
• W2216743954 cites W2042477618 @default.
• W2216743954 cites W2049637750 @default.
• W2216743954 cites W2051258629 @default.
• W2216743954 cites W2059999514 @default.
• W2216743954 cites W2081145901 @default.
• W2216743954 cites W2082734526 @default.
• W2216743954 cites W2086802798 @default.
• W2216743954 cites W2091398245 @default.
• W2216743954 cites W2094305904 @default.
• W2216743954 cites W2107277218 @default.
• W2216743954 cites W2109508815 @default.
• W2216743954 cites W2111278283 @default.
• W2216743954 cites W2124352629 @default.
• W2216743954 cites W2127566937 @default.
• W2216743954 cites W2134295452 @default.
• W2216743954 cites W2134979684 @default.
• W2216743954 cites W2149967205 @default.
• W2216743954 cites W2166291746 @default.
• W2216743954 cites W2172162633 @default.
• W2216743954 cites W2192080449 @default.
• W2216743954 cites W2419240703 @default.
• W2216743954 cites W4241803108 @default.
• W2216743954 cites W4301804843 @default.
• W2216743954 doi "https://doi.org/10.1371/journal.pone.0138504" @default.
• W2216743954 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4575129" @default.
• W2216743954 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26382060" @default.
• W2216743954 hasPublicationYear "2015" @default.
• W2216743954 type Work @default.
• W2216743954 sameAs 2216743954 @default.
• W2216743954 citedByCount "16" @default.
• W2216743954 countsByYear W22167439542016 @default.
• W2216743954 countsByYear W22167439542017 @default.
• W2216743954 countsByYear W22167439542018 @default.
• W2216743954 countsByYear W22167439542019 @default.
• W2216743954 countsByYear W22167439542020 @default.
• W2216743954 countsByYear W22167439542021 @default.
• W2216743954 countsByYear W22167439542023 @default.
• W2216743954 crossrefType "journal-article" @default.
• W2216743954 hasAuthorship W2216743954A5001427039 @default.
• W2216743954 hasAuthorship W2216743954A5002108827 @default.
• W2216743954 hasAuthorship W2216743954A5021495647 @default.
• W2216743954 hasAuthorship W2216743954A5028700388 @default.
• W2216743954 hasAuthorship W2216743954A5031943018 @default.
• W2216743954 hasAuthorship W2216743954A5032077798 @default.
• W2216743954 hasAuthorship W2216743954A5032147007 @default.
• W2216743954 hasAuthorship W2216743954A5036897434 @default.
• W2216743954 hasAuthorship W2216743954A5039144070 @default.
• W2216743954 hasAuthorship W2216743954A5042058980 @default.
• W2216743954 hasAuthorship W2216743954A5046663841 @default.
• W2216743954 hasAuthorship W2216743954A5062875328 @default.
• W2216743954 hasAuthorship W2216743954A5071202457 @default.
• W2216743954 hasAuthorship W2216743954A5075086137 @default.
• W2216743954 hasAuthorship W2216743954A5084769658 @default.
• W2216743954 hasBestOaLocation W22167439541 @default.
• W2216743954 hasConcept C104317684 @default.
• W2216743954 hasConcept C12519072 @default.
• W2216743954 hasConcept C153911025 @default.

• next