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• W2216915433 abstract "A number of recent convergences within neurobiology, and between neurobiology and psychoanalysis, allow us to view autism through a new lens. This perspective highlights biological risk factors that might operate through final common pathways to produce the ASD syndrome. The goal of this article is to integrate and elaborate upon this confluence of findings, and to develop a working model of ASD that could parsimoniously account for central aspects of ASD, promote greater collaboration in research, and lead to more effective treatment. Converging evidence suggests that ASD is a potentially reversible neurodevelopmental disorder in which neurobiological factors – not poor parenting – interfere with the child–caregiver interaction. The infant then experiences deprivation of growth-promoting parental input even though it is available. The model proposed here adds what seems to have been largely unrecognized in the field of autism: the child's experience of social deprivation and isolation signals threat to the child and may result in overwhelming stress with significant psychological (traumatic or toxic stress) and biological (allostatic overload) components and consequences. Allostatic overload results when attempts to cope with threat impose too great a burden, resulting in a pathophysiological state or process that damages the body and predisposes one to the development of disease. Critically, this model proposes that allostatic overload plays a major role in the course of ASD by amplifying the neurobiological vulnerabilities generally considered to make primary contributions to the development of autism. Furthermore, through the process of allostatic overload, neurobiological and psychological factors interact in a nonlinear fashion and are both seen to underlie the symptoms of ASD which develop through maladaptive coping and neuroplasticity. Thus, this model might explain both the progression to, and the ongoing symptoms of, the ASD syndrome. In addition, the model could also account for successful intervention by promoting the reversal of this process via adaptive coping and neuroplasticity. Factors that may facilitate adaptive neuroplasticity include providing an enriched environment, increasing social and emotional connection, and decreasing anxiety, stress, and allostatic load. Personal descriptions of the experience of ASD, as well as psychoanalytic clinical work with children with ASD, are in accord with this model. Psychoanalysis may thus be considered a research tool that assists in uncovering the child's inner world of feelings and meanings, an under-appreciated element in autism. Making sense of the child's experience of isolation and threat helps the ASD child feel understood and less afraid. Clinical material will illustrate how, for some children on the higher end of the autism spectrum, recovery is made more likely by increasing the sense of connection and decreasing the experience of stress." @default.
• W2216915433 created "2016-06-24" @default.
• W2216915433 creator A5060346947 @default.
• W2216915433 date "2015-07-03" @default.
• W2216915433 modified "2023-09-30" @default.
• W2216915433 title "An integrative model of autism spectrum disorder: ASD as a neurobiological disorder of experienced environmental deprivation, early life stress and allostatic overload" @default.
• W2216915433 cites W123418300 @default.
• W2216915433 cites W144537577 @default.
• W2216915433 cites W1498791230 @default.
• W2216915433 cites W1503958172 @default.
• W2216915433 cites W155479038 @default.
• W2216915433 cites W162819727 @default.
• W2216915433 cites W1635412086 @default.
• W2216915433 cites W1717145785 @default.
• W2216915433 cites W1800523239 @default.
• W2216915433 cites W19512262 @default.
• W2216915433 cites W1959428644 @default.
• W2216915433 cites W1963588613 @default.
• W2216915433 cites W1964527618 @default.
• W2216915433 cites W1970780234 @default.
• W2216915433 cites W1972479743 @default.
• W2216915433 cites W1977253605 @default.
• W2216915433 cites W1980505500 @default.
• W2216915433 cites W1980625058 @default.
• W2216915433 cites W1981492377 @default.
• W2216915433 cites W1981760840 @default.
• W2216915433 cites W198191071 @default.
• W2216915433 cites W1984939622 @default.
• W2216915433 cites W1988455141 @default.
• W2216915433 cites W1990051851 @default.
• W2216915433 cites W1993793414 @default.
• W2216915433 cites W1994670218 @default.
• W2216915433 cites W1995530514 @default.
• W2216915433 cites W2000006242 @default.
• W2216915433 cites W2000181935 @default.
• W2216915433 cites W2000385214 @default.
• W2216915433 cites W2001532157 @default.
• W2216915433 cites W2002012536 @default.
• W2216915433 cites W2004265420 @default.
• W2216915433 cites W2005409580 @default.
• W2216915433 cites W2005989043 @default.
• W2216915433 cites W2007655600 @default.
• W2216915433 cites W2008041264 @default.
• W2216915433 cites W2011001109 @default.
• W2216915433 cites W2012665183 @default.
• W2216915433 cites W2013656874 @default.
• W2216915433 cites W2016159321 @default.
• W2216915433 cites W2016359852 @default.
• W2216915433 cites W2016721179 @default.
• W2216915433 cites W2019481862 @default.
• W2216915433 cites W2024611218 @default.
• W2216915433 cites W2025147744 @default.
• W2216915433 cites W2025450822 @default.
• W2216915433 cites W2025653580 @default.
• W2216915433 cites W2027676008 @default.
• W2216915433 cites W2028735881 @default.
• W2216915433 cites W2031598294 @default.
• W2216915433 cites W2033011309 @default.
• W2216915433 cites W2033077710 @default.
• W2216915433 cites W2033583260 @default.
• W2216915433 cites W2034067099 @default.
• W2216915433 cites W2034453108 @default.
• W2216915433 cites W2035506481 @default.
• W2216915433 cites W2035721027 @default.
• W2216915433 cites W2036441276 @default.
• W2216915433 cites W2036626641 @default.
• W2216915433 cites W2038748858 @default.
• W2216915433 cites W2041183012 @default.
• W2216915433 cites W2044009124 @default.
• W2216915433 cites W2047485415 @default.
• W2216915433 cites W2048681789 @default.
• W2216915433 cites W2049423401 @default.
• W2216915433 cites W2051189071 @default.
• W2216915433 cites W2051587828 @default.
• W2216915433 cites W2052072164 @default.
• W2216915433 cites W2054155432 @default.
• W2216915433 cites W2055621916 @default.
• W2216915433 cites W2056432740 @default.
• W2216915433 cites W2057339717 @default.
• W2216915433 cites W2057619579 @default.
• W2216915433 cites W2059762871 @default.
• W2216915433 cites W2066997462 @default.
• W2216915433 cites W2070083499 @default.
• W2216915433 cites W2070420735 @default.
• W2216915433 cites W2070684401 @default.
• W2216915433 cites W2070868801 @default.
• W2216915433 cites W2078824156 @default.
• W2216915433 cites W2080326011 @default.
• W2216915433 cites W2082630431 @default.
• W2216915433 cites W2088477947 @default.
• W2216915433 cites W2090153386 @default.
• W2216915433 cites W2091028497 @default.
• W2216915433 cites W2092522680 @default.
• W2216915433 cites W2093190722 @default.
• W2216915433 cites W2094031576 @default.
• W2216915433 cites W2095096359 @default.
• W2216915433 cites W2096334504 @default.
• W2216915433 cites W2097864095 @default.

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