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- W2216989895 abstract "Recently published in Nature: Cell Death and Discovery,Mahbub et al.1 have demonstrated that polyphenols cansynergistically enhance the action of the topoisomerase IIinhibitors: doxorubicin and etoposide in leukaemia cells. Areduction of glutathione (GSH) was strongly associated withsensitising cells to the pro-apoptotic effects of polyphenols when used in combination with doxorubicin or etoposide. Importantly, when polyphenols and topoisomerase II inhibitors were combined, it was possible to induce asynergistic decrease in cell proliferation (measured as ATPlevels), cell-cycle arrest and induction of apoptosis inleukaemia cell lines." @default.
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- W2216989895 date "2015-12-31" @default.
- W2216989895 modified "2023-10-10" @default.
- W2216989895 title "Glutathione is key to the synergistic enhancement of doxorubicin and etoposide by polyphenols in leukaemia cell lines" @default.
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- W2216989895 doi "https://doi.org/10.1038/cddis.2015.379" @default.
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